Sequence of PAPS2_HUMAN
EC Number:2.7.1.25
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + adenylyl sulfate = ADP + 3'-phosphoadenylyl sulfate
Other sequences found for EC No. 2.7.1.25
General information:
Sequence
0 MSGIKKQKTE NQQKSTNVVY QAHHVSRNKR GQVVGTRGGF RGCTVWLTGL SGAGKTTISF
60 ALEEYLVSHA IPCYSLDGDN VRHGLNRNLG FSPGDREENI RRIAEVAKLF ADAGLVCITS
120 FISPFAKDRE NARKIHESAG LPFFEIFVDA PLNICESRDV KGLYKRARAG EIKGFTGIDS
180 DYEKPETPER VLKTNLSTVS DCVHQVVELL QEQNIVPYTI IKDIHELFVP ENKLDHVRAE
240 AETLPSLSIT KLDLQWVQVL SEGWATPLKG FMREKEYLQV MHFDTLLDDG VINMSIPIVL
300 PVSAEDKTRL EGCSKFVLAH GGRRVAILRD AEFYEHRKEE RCSRVWGTTC TKHPHIKMVM
360 ESGDWLVGGD LQVLEKIRWN DGLDQYRLTP LELKQKCKEM NADAVFAFQL RNPVHNGHAL
420 LMQDTRRRLL ERGYKHPVLL LHPLGGWTKD DDVPLDWRMK QHAAVLEEGV LDPKSTIVAI
480 FPSPMLYAGP TEVQWHCRSR MIAGANFYIV GRDPAGMPHP ETKKDLYEPT HGGKVLSMAP
540 GLTSVEIIPF RVAAYNKAKK AMDFYDPARH NEFDFISGTR MRKLAREGEN PPDGFMAPKA
600 WKVLTDYYRS LEKN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
72002
ul Haque M.F.,King L.M.,Krakow D.,Cantor R.M.,Rusiniak M.E.,Swank R.T.,Superti-Furga A.,Haque S.,Abbas H.,Ahmad W.,Ahmad M.,Cohn D.H.
Mutations in orthologous genes in human spondyloepimetaphyseal dysplasia and the brachymorphic mouse.
Nat. Genet.
20
157-162
1998
72005
Xu Z.-H.,Otterness D.M.,Freimuth R.R.,Carlini E.J.,Wood T.C.,Mitchell S.,Moon E.,Kim U.-J.,Xu J.-P.,Siciliano M.J.,Weinshilboum R.M.
Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 (PAPSS1) and PAPSS2: gene cloning, characterization and chromosomal localization.
Biochem. Biophys. Res. Commun.
268
437-444
2000
72006
Kurima K.,Singh B.,Schwartz N.B.
Genomic organization of the mouse and human genes encoding the ATP sulfurylase/adenosine 5'-phosphosulfate kinase isoform SK2.
J. Biol. Chem.
274
33306-33312
1999
72008
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
72009
Ahmad M.,Haque M.F.,Ahmad W.,Abbas H.,Haque S.,Krakow D.,Rimoin D.L.,Lachman R.S.,Cohn D.H.
Distinct, autosomal recessive form of spondyloepimetaphyseal dysplasia segregating in an inbred Pakistani kindred.
Am. J. Med. Genet.
78
468-473
1998
72010
Noordam C.,Dhir V.,McNelis J.C.,Schlereth F.,Hanley N.A.,Krone N.,Smeitink J.A.,Smeets R.,Sweep F.C.,Claahsen-van der Grinten H.L.,Arlt W.
Inactivating PAPSS2 mutations in a patient with premature pubarche.
N. Engl. J. Med.
360
2310-2318
2009
72011
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
72012
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
72014
Xu Z.-H.,Freimuth R.R.,Eckloff B.,Wieben E.,Weinshilboum R.M.
Human 3'-phosphoadenosine 5'-phosphosulfate synthetase 2 (PAPSS2) pharmacogenetics: gene resequencing, genetic polymorphisms and functional characterization of variant allozymes.
Pharmacogenetics
12
11-21
2002
72015
Tueysuez B.,Yilmaz S.,Guel E.,Kolb L.,Bilguvar K.,Evliyaoglu O.,Guenel M.
Spondyloepimetaphyseal dysplasia Pakistani type: expansion of the phenotype.
Am. J. Med. Genet. A
161A
1300-1308
2013
72016
Iida A.,Simsek-Kiper P.O.,Mizumoto S.,Hoshino T.,Elcioglu N.,Horemuzova E.,Geiberger S.,Yesil G.,Kayserili H.,Utine G.E.,Boduroglu K.,Watanabe S.,Ohashi H.,Alanay Y.,Sugahara K.,Nishimura G.,Ikegawa S.
Clinical and radiographic features of the autosomal recessive form of brachyolmia caused by PAPSS2 mutations.
Hum. Mutat.
34
1381-1386
2013
72017
Oostdijk W.,Idkowiak J.,Mueller J.W.,House P.J.,Taylor A.E.,O'Reilly M.W.,Hughes B.A.,de Vries M.C.,Kant S.G.,Santen G.W.,Verkerk A.J.,Uitterlinden A.G.,Wit J.M.,Losekoot M.,Arlt W.
PAPSS2 deficiency causes androgen excess via impaired DHEA sulfation - in vitro and in vivo studies in a family harboring two novel PAPSS2 mutations.
J. Clin. Endocrinol. Metab.
2015
0-0
2015
