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Sequence of CFAB_HUMAN

EC Number:3.4.21.47

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
alternative-complement-pathway C3/C5 convertase
P00751
Homo sapiens
764
85533
Reaction
Cleavage of Arg-/-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg-/- bond in complement component C5 alpha-chain to yield C5a and C5b
Other sequences found for EC No. 3.4.21.47

General information:

Sequence
show sequence in fasta format
  0 MGSNLSPQLC LMPFILGLLS GGVTTTPWSL ARPQGSCSLE GVEIKGGSFR LLQEGQALEY
 60 VCPSGFYPYP VQTRTCRSTG SWSTLKTQDQ KTVRKAECRA IHCPRPHDFE NGEYWPRSPY
120 YNVSDEISFH CYDGYTLRGS ANRTCQVNGR WSGQTAICDN GAGYCSNPGI PIGTRKVGSQ
180 YRLEDSVTYH CSRGLTLRGS QRRTCQEGGS WSGTEPSCQD SFMYDTPQEV AEAFLSSLTE
240 TIEGVDAEDG HGPGEQQKRK IVLDPSGSMN IYLVLDGSDS IGASNFTGAK KCLVNLIEKV
300 ASYGVKPRYG LVTYATYPKI WVKVSEADSS NADWVTKQLN EINYEDHKLK SGTNTKKALQ
360 AVYSMMSWPD DVPPEGWNRT RHVIILMTDG LHNMGGDPIT VIDEIRDLLY IGKDRKNPRE
420 DYLDVYVFGV GPLVNQVNIN ALASKKDNEQ HVFKVKDMEN LEDVFYQMID ESQSLSLCGM
480 VWEHRKGTDY HKQPWQAKIS VIRPSKGHES CMGAVVSEYF VLTAAHCFTV DDKEHSIKVS
540 VGGEKRDLEI EVVLFHPNYN INGKKEAGIP EFYDYDVALI KLKNKLKYGQ TIRPICLPCT
600 EGTTRALRLP PTTTCQQQKE ELLPAQDIKA LFVSEEEKKL TRKEVYIKNG DKKGSCERDA
660 QYAPGYDKVK DISEVVTPRF LCTGGVSPYA DPNTCRGDSG GPLIVHKRSR FIQVGVISWG
720 VVDVCKNQKR QKQVPAHARD FHINLFQVLP WLKEKLQDED LGFL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
779758
Davrinche C.,Abbal M.,Clerc A.
Molecular characterization of human complement factor B subtypes.
Immunogenetics
32
309-312
1990
779759
Mejia J.E.,Jahn I.,de la Salle H.,Hauptmann G.
Human factor B. Complete cDNA sequence of the BF*S allele.
Hum. Immunol.
39
49-53
1994
779760
Schwaeble W.,Luettig B.,Sokolowski T.,Estaller C.,Weiss E.H.,Meyer Zum Bueschenfelde K.-H.,Whaley K.,Dippold W.
Human complement factor B: functional properties of a recombinant zymogen of the alternative activation pathway convertase.
Immunobiology
188
221-232
1993
779761
Horiuchi T.,Kim S.,Matsumoto M.,Watanabe I.,Fujita S.,Volanakis J.E.
Human complement factor B: cDNA cloning, nucleotide sequencing, phenotypic conversion by site-directed mutagenesis and expression.
Mol. Immunol.
30
1587-1592
1993
779763
Xie T.,Rowen L.,Aguado B.,Ahearn M.E.,Madan A.,Qin S.,Campbell R.D.,Hood L.
Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse.
Genome Res.
13
2621-2636
2003
779766
Mungall A.J.,Palmer S.A.,Sims S.K.,Edwards C.A.,Ashurst J.L.,Wilming L.,Jones M.C.,Horton R.,Hunt S.E.,Scott C.E.,Gilbert J.G.R.,Clamp M.E.,Bethel G.,Milne S.,Ainscough R.,Almeida J.P.,Ambrose K.D.,Andrews T.D.,Ashwell R.I.S.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Barker D.J.,Barlow K.F.,Bates K.,Beare D.M.,Beasley H.,Beasley O.,Bird C.P.,Blakey S.E.,Bray-Allen S.,Brook J.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Carder C.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clark G.,Clee C.M.,Clegg S.,Cobley V.,Collier R.E.,Collins J.E.,Colman L.K.,Corby N.R.,Coville G.J.,Culley K.M.,Dhami P.,Davies J.,Dunn M.,Earthrowl M.E.,Ellington A.E.,Evans K.A.,Faulkner L.,Francis M.D.,Frankish A.,Frankland J.,French L.,Garner P.,Garnett J.,Ghori M.J.,Gilby L.M.,Gillson C.J.,Glithero R.J.,Grafham D.V.,Grant M.,Gribble S.,Griffiths C.,Griffiths M.N.D.,Hall R.,Halls K.S.,Hammond S.,Harley J.L.,Hart E.A.,Heath P.D.,Heathcott R.,Holmes S.J.,Howden P.J.,Howe K.L.,Howell G.R.,Huckle E.,Humphray S.J.,Humphries M.D.,Hunt A.R.,Johnson C.M.,Joy A.A.,Kay M.,Keenan S.J.,Kimberley A.M.,King A.,Laird G.K.,Langford C.,Lawlor S.,Leongamornlert D.A.,Leversha M.,Lloyd C.R.,Lloyd D.M.,Loveland J.E.,Lovell J.,Martin S.,Mashreghi-Mohammadi M.,Maslen G.L.,Matthews L.,McCann O.T.,McLaren S.J.,McLay K.,McMurray A.,Moore M.J.F.,Mullikin J.C.,Niblett D.,Nickerson T.,Novik K.L.,Oliver K.,Overton-Larty E.K.,Parker A.,Patel R.,Pearce A.V.,Peck A.I.,Phillimore B.J.C.T.,Phillips S.,Plumb R.W.,Porter K.M.,Ramsey Y.,Ranby S.A.,Rice C.M.,Ross M.T.,Searle S.M.,Sehra H.K.,Sheridan E.,Skuce C.D.,Smith S.,Smith M.,Spraggon L.,Squares S.L.,Steward C.A.,Sycamore N.,Tamlyn-Hall G.,Tester J.,Theaker A.J.,Thomas D.W.,Thorpe A.,Tracey A.,Tromans A.,Tubby B.,Wall M.,Wallis J.M.,West A.P.,White S.S.,Whitehead S.L.,Whittaker H.,Wild A.,Willey D.J.,Wilmer T.E.,Wood J.M.,Wray P.W.,Wyatt J.C.,Young L.,Younger R.M.,Bentley D.R.,Coulson A.,Durbin R.M.,Hubbard T.,Sulston J.E.,Dunham I.,Rogers J.,Beck S.
The DNA sequence and analysis of human chromosome 6.
Nature
425
805-811
2003
779768
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
779769
Mole J.E.,Anderson J.K.,Davison E.A.,Woods D.E.
Complete primary structure for the zymogen of human complement factor B.
J. Biol. Chem.
259
3407-3412
1984
779770
Christie D.L.,Gagnon J.
Amino acid sequence of the Bb fragment from complement Factor B. Sequence of the major cyanogen bromide-cleavage peptide (CB-II) and completion of the sequence of the Bb fragment.
Biochem. J.
209
61-70
1983
779771
Campbell R.D.,Porter R.R.
Molecular cloning and characterization of the gene coding for human complement protein factor B.
Proc. Natl. Acad. Sci. U.S.A.
80
4464-4468
1983
779772
Woods D.E.,Markham A.F.,Ricker A.T.,Goldberger G.,Colten H.R.
Isolation of cDNA clones for the human complement protein factor B, a class III major histocompatibility complex gene product.
Proc. Natl. Acad. Sci. U.S.A.
79
5661-5665
1982
779773
Morley B.J.,Campbell R.D.
Internal homologies of the Ba fragment from human complement component Factor B, a class III MHC antigen.
EMBO J.
3
153-157
1984
779774
Wu L.C.,Morley B.J.,Campbell R.D.
Cell-specific expression of the human complement protein factor B gene: evidence for the role of two distinct 5'-flanking elements.
Cell
48
331-342
1987
779775
Niemann M.A.,Bhown A.S.,Miller E.J.
The principal site of glycation of human complement factor B.
Biochem. J.
274
473-480
1991
779776
Liu T.,Qian W.-J.,Gritsenko M.A.,Camp D.G. II,Monroe M.E.,Moore R.J.,Smith R.D.
Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.
J. Proteome Res.
4
2070-2080
2005
779777
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
779778
Slade C.,Bosco J.,Unglik G.,Bleasel K.,Nagel M.,Winship I.
Deficiency in complement factor B.
N. Engl. J. Med.
369
1667-1669
2013
779779
Jing H.,Xu Y.,Carson M.,Moore D.,Macon K.J.,Volanakis J.E.,Narayana S.V.L.
New structural motifs on the chymotrypsin fold and their potential roles in complement factor B.
EMBO J.
19
164-173
2000
779780
Milder F.J.,Gomes L.,Schouten A.,Janssen B.J.,Huizinga E.G.,Romijn R.A.,Hemrika W.,Roos A.,Daha M.R.,Gros P.
Factor B structure provides insights into activation of the central protease of the complement system.
Nat. Struct. Mol. Biol.
14
224-228
2007
779781
Janssen B.J.,Gomes L.,Koning R.I.,Svergun D.I.,Koster A.J.,Fritzinger D.C.,Vogel C.-W.,Gros P.
Insights into complement convertase formation based on the structure of the factor B-cobra venom factor complex.
EMBO J.
28
2469-2478
2009
779782
Pedersen D.V.,Roumenina L.,Jensen R.K.,Gadeberg T.A.,Marinozzi C.,Picard C.,Rybkine T.,Thiel S.,Soerensen U.B.,Stover C.,Fremeaux-Bacchi V.,Andersen G.R.
Functional and structural insight into properdin control of complement alternative pathway amplification.
EMBO J.
36
1084-1099
2017
779783
Pedersen D.V.,Gadeberg T.A.F.,Thomas C.,Wang Y.,Joram N.,Jensen R.K.,Mazarakis S.M.M.,Revel M.,El Sissy C.,Petersen S.V.,Lindorff-Larsen K.,Thiel S.,Laursen N.S.,Fremeaux-Bacchi V.,Andersen G.R.
Structural Basis for Properdin Oligomerization and Convertase Stimulation in the Human Complement System.
Front. Immunol.
10
2007-2007
2019
779784
Gold B.,Merriam J.E.,Zernant J.,Hancox L.S.,Taiber A.J.,Gehrs K.,Cramer K.,Neel J.,Bergeron J.,Barile G.R.,Smith R.T.,Hageman G.S.,Dean M.,Allikmets R.
Variation in factor B (BF) and complement component 2 (C2) genes is associated with age-related macular degeneration.
Nat. Genet.
38
458-462
2006
779785
Goicoechea de Jorge E.,Harris C.L.,Esparza-Gordillo J.,Carreras L.,Arranz E.A.,Garrido C.A.,Lopez-Trascasa M.,Sanchez-Corral P.,Morgan B.P.,Rodriguez de Cordoba S.
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome.
Proc. Natl. Acad. Sci. U.S.A.
104
240-245
2007
779786
Maga T.K.,Nishimura C.J.,Weaver A.E.,Frees K.L.,Smith R.J.H.
Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome.
Hum. Mutat.
31
0-0
2010