Sequence of BLM_HUMAN
EC Number:3.6.4.12
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Other sequences found for EC No. 3.6.4.12
General information:
Sequence
0 MAAVPQNNLQ EQLERHSART LNNKLSLSKP KFSGFTFKKK TSSDNNVSVT NVSVAKTPVL
60 RNKDVNVTED FSFSEPLPNT TNQQRVKDFF KNAPAGQETQ RGGSKSLLPD FLQTPKEVVC
120 TTQNTPTVKK SRDTALKKLE FSSSPDSLST INDWDDMDDF DTSETSKSFV TPPQSHFVRV
180 STAQKSKKGK RNFFKAQLYT TNTVKTDLPP PSSESEQIDL TEEQKDDSEW LSSDVICIDD
240 GPIAEVHINE DAQESDSLKT HLEDERDNSE KKKNLEEAEL HSTEKVPCIE FDDDDYDTDF
300 VPPSPEEIIS ASSSSSKCLS TLKDLDTSDR KEDVLSTSKD LLSKPEKMSM QELNPETSTD
360 CDARQISLQQ QLIHVMEHIC KLIDTIPDDK LKLLDCGNEL LQQRNIRRKL LTEVDFNKSD
420 ASLLGSLWRY RPDSLDGPME GDSCPTGNSM KELNFSHLPS NSVSPGDCLL TTTLGKTGFS
480 ATRKNLFERP LFNTHLQKSF VSSNWAETPR LGKKNESSYF PGNVLTSTAV KDQNKHTASI
540 NDLERETQPS YDIDNFDIDD FDDDDDWEDI MHNLAASKSS TAAYQPIKEG RPIKSVSERL
600 SSAKTDCLPV SSTAQNINFS ESIQNYTDKS AQNLASRNLK HERFQSLSFP HTKEMMKIFH
660 KKFGLHNFRT NQLEAINAAL LGEDCFILMP TGGGKSLCYQ LPACVSPGVT VVISPLRSLI
720 VDQVQKLTSL DIPATYLTGD KTDSEATNIY LQLSKKDPII KLLYVTPEKI CASNRLISTL
780 ENLYERKLLA RFVIDEAHCV SQWGHDFRQD YKRMNMLRQK FPSVPVMALT ATANPRVQKD
840 ILTQLKILRP QVFSMSFNRH NLKYYVLPKK PKKVAFDCLE WIRKHHPYDS GIIYCLSRRE
900 CDTMADTLQR DGLAALAYHA GLSDSARDEV QQKWINQDGC QVICATIAFG MGIDKPDVRF
960 VIHASLPKSV EGYYQESGRA GRDGEISHCL LFYTYHDVTR LKRLIMMEKD GNHHTRETHF
1020 NNLYSMVHYC ENITECRRIQ LLAYFGENGF NPDFCKKHPD VSCDNCCKTK DYKTRDVTDD
1080 VKSIVRFVQE HSSSQGMRNI KHVGPSGRFT MNMLVDIFLG SKSAKIQSGI FGKGSAYSRH
1140 NAERLFKKLI LDKILDEDLY INANDQAIAY VMLGNKAQTV LNGNLKVDFM ETENSSSVKK
1200 QKALVAKVSQ REEMVKKCLG ELTEVCKSLG KVFGVHYFNI FNTVTLKKLA ESLSSDPEVL
1260 LQIDGVTEDK LEKYGAEVIS VLQKYSEWTS PAEDSSPGIS LSSSRGPGRS AAEELDEEIP
1320 VSSHYFASKT RNERKRKKMP ASQRSKRRKT ASSGSKAKGG SATCRKISSK TKSSSIIGSS
1380 SASHTSQATS GANSKLGIMA PPKPINRPFL KPSYAFS
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
774837
Ellis N.A.,Groden J.,Ye T.-Z.,Straughen J.,Lennon D.J.,Ciocci S.,Proytcheva M.,German J.
The Bloom's syndrome gene product is homologous to RecQ helicases.
Cell
83
655-666
1995
774838
Karow J.K.,Chakraverty R.K.,Hickson I.D.
The Bloom's syndrome gene product is a 3'-5' DNA helicase.
J. Biol. Chem.
272
30611-30614
1997
774840
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
774841
Kaneko H.,Orii K.O.,Matsui E.,Shimozawa N.,Fukao T.,Matsumoto T.,Shimamoto A.,Furuichi Y.,Hayakawa S.,Kasahara K.,Kondo N.
BLM (the causative gene of Bloom syndrome) protein translocation into the nucleus by a nuclear localization signal.
Biochem. Biophys. Res. Commun.
240
348-353
1997
774842
Wang Y.,Cortez D.,Yazdi P.,Neff N.,Elledge S.J.,Qin J.
BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures.
Genes Dev.
14
927-939
2000
774843
Pichierri P.,Franchitto A.,Rosselli F.
BLM and the FANC proteins collaborate in a common pathway in response to stalled replication forks.
EMBO J.
23
3154-3163
2004
774844
Langland G.,Elliott J.,Li Y.,Creaney J.,Dixon K.,Groden J.
The BLM helicase is necessary for normal DNA double-strand break repair.
Cancer Res.
62
2766-2770
2002
774845
Yin J.,Sobeck A.,Xu C.,Meetei A.R.,Hoatlin M.,Li L.,Wang W.
BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.
EMBO J.
24
1465-1476
2005
774846
Raynard S.,Bussen W.,Sung P.
A double Holliday junction dissolvasome comprising BLM, topoisomerase III alpha, and BLAP75.
J. Biol. Chem.
281
13861-13864
2006
774847
Beausoleil S.A.,Villen J.,Gerber S.A.,Rush J.,Gygi S.P.
A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Nat. Biotechnol.
24
1285-1292
2006
774848
Pereira M.,Mason P.,Szczesny R.J.,Maddukuri L.,Dziwura S.,Jedrzejczak R.,Paul E.,Wojcik A.,Dybczynska L.,Tudek B.,Bartnik E.,Klysik J.,Bohr V.A.,Stepien P.P.
Interaction of human SUV3 RNA/DNA helicase with BLM helicase; loss of the SUV3 gene results in mouse embryonic lethality.
Mech. Ageing Dev.
128
609-617
2007
774849
Xu D.,Guo R.,Sobeck A.,Bachrati C.Z.,Yang J.,Enomoto T.,Brown G.W.,Hoatlin M.E.,Hickson I.D.,Wang W.
RMI, a new OB-fold complex essential for Bloom syndrome protein to maintain genome stability.
Genes Dev.
22
2843-2855
2008
774850
Singh T.R.,Ali A.M.,Busygina V.,Raynard S.,Fan Q.,Du C.-H.,Andreassen P.R.,Sung P.,Meetei A.R.
BLAP18/RMI2, a novel OB-fold-containing protein, is an essential component of the Bloom helicase-double Holliday junction dissolvasome.
Genes Dev.
22
2856-2868
2008
774851
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
774852
Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
Sci. Signal.
2
0-0
2009
774853
Choudhary C.,Kumar C.,Gnad F.,Nielsen M.L.,Rehman M.,Walther T.C.,Olsen J.V.,Mann M.
Lysine acetylation targets protein complexes and co-regulates major cellular functions.
Science
325
834-840
2009
774854
Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
Sci. Signal.
3
0-0
2010
774855
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
774856
Nimonkar A.V.,Genschel J.,Kinoshita E.,Polaczek P.,Campbell J.L.,Wyman C.,Modrich P.,Kowalczykowski S.C.
BLM-DNA2-RPA-MRN and EXO1-BLM-RPA-MRN constitute two DNA end resection machineries for human DNA break repair.
Genes Dev.
25
350-362
2011
774857
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
774858
Wan L.,Han J.,Liu T.,Dong S.,Xie F.,Chen H.,Huang J.
Scaffolding protein SPIDR/KIAA0146 connects the Bloom syndrome helicase with homologous recombination repair.
Proc. Natl. Acad. Sci. U.S.A.
110
10646-10651
2013
774859
Hendriks I.A.,Treffers L.W.,Verlaan-de Vries M.,Olsen J.V.,Vertegaal A.C.
SUMO-2 orchestrates chromatin modifiers in response to DNA damage.
Cell Rep.
10
1778-1791
2015
774860
Xiao Z.,Chang J.G.,Hendriks I.A.,Sigurdsson J.O.,Olsen J.V.,Vertegaal A.C.
System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.
Mol. Cell. Proteomics
14
1419-1434
2015
774861
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
774862
Sato A.,Mishima M.,Nagai A.,Kim S.Y.,Ito Y.,Hakoshima T.,Jee J.G.,Kitano K.
Solution structure of the HRDC domain of human Bloom syndrome protein BLM.
J. Biochem.
148
517-525
2010
774863
Kim Y.M.,Choi B.S.
Structure and function of the regulatory HRDC domain from human Bloom syndrome protein.
Nucleic Acids Res.
38
7764-7777
2010
774864
Kim S.Y.,Hakoshima T.,Kitano K.
Structure of the RecQ C-terminal domain of human Bloom syndrome protein.
Sci. Rep.
3
3294-3294
2013
774865
Swan M.K.,Legris V.,Tanner A.,Reaper P.M.,Vial S.,Bordas R.,Pollard J.R.,Charlton P.A.,Golec J.M.,Bertrand J.A.
Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA.
Acta Crystallogr. D
70
1465-1475
2014
774866
Park C.J.,Ko J.,Ryu K.S.,Choi B.S.
Solution structure of the RecQ C-terminal domain of human Bloom syndrome protein.
J. Biomol. NMR
58
141-147
2014
774867
Newman J.A.,Savitsky P.,Allerston C.K.,Bizard A.H.,Ozer O.,Sarlos K.,Liu Y.,Pardon E.,Steyaert J.,Hickson I.D.,Gileadi O.
Crystal structure of the Bloom's syndrome heli case indicates a role for the HRDC domain in conformational changes.
Nucleic Acids Res.
43
5221-5235
2015
774868
Shi J.,Chen W.F.,Zhang B.,Fan S.H.,Ai X.,Liu N.N.,Rety S.,Xi X.G.
A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation.
J. Biol. Chem.
292
5909-5920
2017
774869
Foucault F.,Vaury C.,Barakat A.,Thibout D.,Planchon P.,Jaulin C.,Praz F.,Amor-Gueret M.
Characterization of a new BLM mutation associated with a topoisomerase II alpha defect in a patient with Bloom's syndrome.
Hum. Mol. Genet.
6
1427-1434
1997
774870
Barakat A.,Ababou M.,Onclercq R.,Dutertre S.,Chadli E.,Hda N.,Benslimane A.,Amor-Gueret M.
Identification of a novel BLM missense mutation (2706T>C) in a Moroccan patient with Bloom's syndrome.
Hum. Mutat.
15
584-585
2000
