Sequence of ATM_MOUSE
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
show sequence in normal format
>Q62388|non-specific serine/threonine protein kinase|EC 2.7.11.1|Mus musculus|Swiss-Prot
MSLALNDLLICCRQLEHDRATERRKEVDKFKRLIQDPETVQHLDRHSDSKQGKYLNWDAV
FRFLQKYIQKEMESLRTAKSNVSATTQSSRQKKMQEISSLVRYFIKCANKRAPRLKCQDL
LNYVMDTVKDSSNGLTYGADCSNILLKDILSVRKYWCEVSQQQWLELFSLYFRLYLKPSQ
DINRVLVARIIHAVTRGCCSQTDGLPSKFLDLFSKAIQYARQEKSSPGLSHILAALNIFL
KSLAVNFRKRVCEAGDEILPTLLYIWTQHRLNDSLKEVIIELIQLQIYIHHPQGARAPEE
GAYESMKWKSILYNLYDLLVNEISHIGSRGKYSSGSRNIAVKENLIDLMADICYQLFDAD
TRSVEISQSYVTQRESTDYSVPCKRRKIDVGWEVIKDYLQKSQSDFDLVPWLQITTRLIS
KYPSSLPNCELSPLILILYQLLPQQRRGERIPYVLRCLKEVALCQGKKSNLESSQKSDLL
KLWIKIWSITFRGISSGQTQTENFGLLEAIIQGSLVELDREFWKLFTGSACKPSSPSVCC
LTLALSICVVPDAIKMGTEQSVCEANRSFSVKESIMRWLLFYQLEDDLEDSTELPPILQS
NFPHLVVEKILVSLTMKNSKAAMKFFQSVPECEQHCEDKEEPSFSEVEELFLQTTFDKMD
FLTTVKEYAVEKFQSSVGFSVQQNLKESLDHYLLGLSEQLLSNYSSEITSSETLVRCSSL
LVGVLGCYCYMGIITEDEAHKSELFQKAKSLMQCAGESISLFKNKTNEESRIGSLRNVMH
LCTSCLCIHTKHTPNKIASGFFLRLLTSKLMNDIADICKSLASCTKKPLDHGVHPGEDDE
DGGGCDSLMEAEGPSSTGLSTAYPASSVSDANDYGENQNAVGAMSPLAADYLSKQDHLLL
DMLRFLGRSVTASQSHTVSFRGADIRRKLLLLLDSSILDLMKPLHLHMYLVLLKDLPGNE
HSLPMEDVVELLQPLSLVCSLHRRDQDVCKTILSNVLHIVTNLGQGSVDMESTRIAQGHF
LTVMGAFWHLTKEKKCVFSVRMALVKCLQTLLEADPYSEWAILNVKGQDFPVNEAFSQFL
ADDHHQVRMLAAGSVNRLFQDMRQGDFSRSLKALPLKFQQTSFNNAYTTAEAGIRGLLCD
SQNPDLLDEIYNRKSVLLMMIAVVLHCSPVCEKQALFALCKSVKENRLEPHLVKKVLEKV
SESFGCRSLEDFMISHLDYLVLEWLNLQDTEYSLSSFPFMLLNYTSIEDFYRSCYKILIP
HLVIRSHFDEVKSIANQIQKCWKSLLVDCFPKILVHILPYFAYEGTRDSYVSQKRETATK
VYDTLKGEDFLGKQIDQVFISNLPEIVVELLMTLHETADSADSDASQSATALCDFSGDLD
PAPNPPYFPSHVIQATFAYISNCHKTKFKSILEILSKIPDSYQKILLAICEQAAETNNVF
KKHRILKIYHLFVSLLLKDIQSGLGGAWAFVLRDVIYTLIHYINKRSSHFTDVSLRSFSL
CCDLLSRVCHTAVTQCKDALESHLHVIVGTLIPLVDYQEVQEQVLDLLKYLVIDNKDNKN
LSVTIKLLDPFPDHVIFKDLRLTQQKIKYSGGPFSLLEEINHFLSVSAYNPLPLTRLEGL
KDLRRQLEQHKDQMLDLLRASQDNPQDGIVVKLVVSLLQLSKMAVNQTGEREVLEAVGRC
LGEIGPLDFSTIAVQHNKDVSYTKAYGLPEDRELQWTLIMLTALNNTLVEDSVKIRSAAA
TCLKNILATKIGHIFWENYKTSADPMLTYLQPFRTSRKKFLEVPRSVKEDVLEGLDAVNL
WVPQSESHDIWIKTLTCAFLDSGGINSEILQLLKPMCEVKTDFCQMLLPYLIHDVLLQDT
HESWRTLLSAHVRGFFTSCFKHSSQASRSATPANSDSESENFLRCCLDKKSQRTMLAVVD
YLRRQKRPSSGTAFDDAFWLDLNYLEVAKVAQSCSAHFTALLYAEIYSDKKSTDEQEKRS
PTFEEGSQGTTISSLSEKSKEETGISLQDLLLEIYRSIGEPDSLYGCGGGKMLQPLTRIR
TYEHEATWEKALVTYDLETSISSSTRQSGIIQALQNLGLSHILSVYLKGLDYERREWCAE
LQELRYQAAWRNMQWGLCASAGQEVEGTSYHESLYNALQCLRNREFSTFYESLRYASLFR
VKEVEELSKGSLESVYSLYPTLSRLQAIGELENSGELFSRSVTDRERSEAYWKWQKHSQL
LKDSDFSFQEPLMALRTVILETLVQKEMERSQGACSKDILTKHLVEFSVLARTFKNTQLP
ERAIFKIKQYNSAICGISEWHLEEAQVFWAKKEQSLALSILKQMIKKLDSSFKDKENDAG
LKVIYAECLRVCGSWLAETCLENPAVIMQTYLEKAVKVAGSYDGNSRELRNGQMKAFLSL
ARFSDTQYQRIENYMKSSEFENKQTLLKRAKEEVGLLREHKIQTNRYTVKVQRELELDEC
ALRALREDRKRFLCKAVENYINCLLSGEEHDLWVFRLCSLWLENSGVSEVNGMMKKDGMK
ISSYKFLPLMYQLAARMGTKMTGGLGFHEVLNNLISRISLDHPHHTLFIILALANANKDE
FLSKPETTRRSRITKSTSKENSHLDEDRTEAATRIIHSIRSKRCKMVKDMEALCDAYIIL
ANMDASQWRAQRKGINIPANQPITKLKNLEDVVVPTMEIKVDPTGEYENLVTIKSFKTEF
RLAGGLNLPKIIDCVGSDGKERRQLVKGRDDLRQDAVMQQVFQMCNTLLQRNTETRKRKL
TICTYKVVPLSQRSGVLEWCTGTVPIGEYLVNSEDGAHRRYRPNDFSANQCQKKMMEVQK
KSFEEKYDTFMTICQNFEPVFRYFCMEKFLDPAVWFEKRLAYTRSVATSSIVGYILGLGD
RHVQNILINEQSAELVHIDLGVAFEQGKILPTPETVPFRLSRDIVDGMGITGVEGVFRRC
CEKTMEVMRSSQETLLTIVEVLLYDPLFDWTMNPLKALYLQQRPEDESDLHSTPNADDQE
CKQSLSDTDQSFNKVAERVLMRLQEKLKGVEEGTVLSVGGQVNLLIQQAMDPKNLSRLFP
GWKAWV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
772029
Pecker I.,Avraham K.B.,Gilbert D.J.,Savitsky K.,Rotman G.,Harnik R.,Fukao T.,Schroeck E.,Hirotsume S.,Tagle D.A.,Collins F.S.,Wynshaw-Boris A.,Ried T.,Copeland N.G.,Jenkins N.A.,Shiloh Y.,Ziv Y.
Identification and chromosomal localization of Atm, the mouse homolog of the ataxia-telangiectasia gene.
Genomics
35
39-45
1996
772030
Church D.M.,Goodstadt L.,Hillier L.W.,Zody M.C.,Goldstein S.,She X.,Bult C.J.,Agarwala R.,Cherry J.L.,DiCuccio M.,Hlavina W.,Kapustin Y.,Meric P.,Maglott D.,Birtle Z.,Marques A.C.,Graves T.,Zhou S.,Teague B.,Potamousis K.,Churas C.,Place M.,Herschleb J.,Runnheim R.,Forrest D.,Amos-Landgraf J.,Schwartz D.C.,Cheng Z.,Lindblad-Toh K.,Eichler E.E.,Ponting C.P.
Lineage-specific biology revealed by a finished genome assembly of the mouse.
PLoS Biol.
7
0-0
2009
772031
Barlow C.,Hirotsune S.,Paylor R.,Liyanage M.,Eckhaus M.,Collins F.,Shiloh Y.,Crawley J.N.,Ried T.,Tagle D.,Wynshaw-Boris A.
Atm-deficient mice: a paradigm of ataxia telangiectasia.
Cell
86
159-171
1996
772032
Lakin N.D.,Weber P.,Stankovic T.,Rottinghaus S.T.,Taylor A.M.R.,Jackson S.P.
Analysis of the ATM protein in wild-type and ataxia telangiectasia cells.
Oncogene
13
2707-2716
1996
772033
Soares H.D.,Morgan J.I.,McKinnon P.J.
Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia.
Neuroscience
86
1045-1054
1998
772034
Lim D.-S.,Kirsch D.G.,Canman C.E.,Ahn J.-H.,Ziv Y.,Newman L.S.,Darnell R.B.,Shiloh Y.,Kastan M.B.
ATM binds to beta-adaptin in cytoplasmic vesicles.
Proc. Natl. Acad. Sci. U.S.A.
95
10146-10151
1998
772035
Burma S.,Chen B.P.,Murphy M.,Kurimasa A.,Chen D.J.
ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
J. Biol. Chem.
276
42462-42467
2001
772036
Adams C.J.,Graham A.L.,Jansson M.,Coutts A.S.,Edelmann M.,Smith L.,Kessler B.,La Thangue N.B.
ATM and Chk2 kinase target the p53 cofactor Strap.
EMBO Rep.
9
1222-1229
2008
772037
Daniel J.A.,Pellegrini M.,Lee J.H.,Paull T.T.,Feigenbaum L.,Nussenzweig A.
Multiple autophosphorylation sites are dispensable for murine ATM activation in vivo.
J. Cell Biol.
183
777-783
2008
772038
Hewitt S.L.,Yin B.,Ji Y.,Chaumeil J.,Marszalek K.,Tenthorey J.,Salvagiotto G.,Steinel N.,Ramsey L.B.,Ghysdael J.,Farrar M.A.,Sleckman B.P.,Schatz D.G.,Busslinger M.,Bassing C.H.,Skok J.A.
RAG-1 and ATM coordinate monoallelic recombination and nuclear positioning of immunoglobulin loci.
Nat. Immunol.
10
655-664
2009
772039
Huttlin E.L.,Jedrychowski M.P.,Elias J.E.,Goswami T.,Rad R.,Beausoleil S.A.,Villen J.,Haas W.,Sowa M.E.,Gygi S.P.
A tissue-specific atlas of mouse protein phosphorylation and expression.
Cell
143
1174-1189
2010
772040
Zhao B.,Zhang W.D.,Duan Y.L.,Lu Y.Q.,Cun Y.X.,Li C.H.,Guo K.,Nie W.H.,Li L.,Zhang R.,Zheng P.
Filia Is an ESC-Specific Regulator of DNA Damage Response and Safeguards Genomic Stability.
Cell Stem Cell
16
684-698
2015
772041
Hung P.J.,Johnson B.,Chen B.R.,Byrum A.K.,Bredemeyer A.L.,Yewdell W.T.,Johnson T.E.,Lee B.J.,Deivasigamani S.,Hindi I.,Amatya P.,Gross M.L.,Paull T.T.,Pisapia D.J.,Chaudhuri J.,Petrini J.J.H.,Mosammaparast N.,Amarasinghe G.K.,Zha S.,Tyler J.K.,Sleckman B.P.
MRI is a DNA damage response adaptor during classical non-homologous end joining.
Mol. Cell
71
332-342
2018
