Sequence of NPR1_YEAST
EC Number:2.7.11.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
non-specific serine/threonine protein kinase
P22211
Saccharomyces cerevisiae (strain ATCC 204508 / S288c)
790
85990
Reaction
ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate
Other sequences found for EC No. 2.7.11.1
General information:
Sequence
0 MSSLTRLLQE KRKNETSNSS PRTSADTLTT TPESQSLDLH SRNKSSSHIG SVSNSSSSDR
60 NRANVPVPGS VTTVTQIYSE EDSSSTAGSS LDDRNQFSSS FLNANFAHTA SFYGTSAQSR
120 DRFGSLINDQ GTAGLSSHGG SFAAQNRITS RLSTTSHTSG RAIPSLSSSI PYSVPNSNKD
180 NNSSNSNSSS LSSSWLETYA GGMPNNISAI DSNVISSPKV DSVEPRFVIS KQKLQKASMD
240 SNNANATQSR SISRSGSFSS QLGNFFFSKN SKESSNSNSA GMSFSANSNG PSPNIKNPNV
300 TNGSTPIPKP IRARQSSIYS ASRQPTGSYT DNFYGSPSSV HDHLPPSQSV PRSQHSSIGD
360 LKRFFKKSSN SNLSSNSNNV IPNGSPLSSG IAVPSHSHSS SHFAAGNNSY STSYNGNGDT
420 IYSHSHGGSG IPFSKRYIKT GADLGAGAGG SVKLAQRISD NKIFAVKEFR TKFENESKRD
480 YVKKITSEYC IGTTLNHPNI IETIEIVYEN DRILQVMEYC EYDLFAIVMS NKMSYEEICC
540 CFKQILTGVQ YLHSIGLAHR DLKLDNCVIN EKGIVKLIDF GAAVVFSYPF SKNLVEASGI
600 VGSDPYLAPE VCIFAKYDPR PVDIWSSAII FACMILKKFP WKIPKLRDNS FKLFCSGRDC
660 DSLSSLVTRT PDPPSYDESH STEKKKPESS SNNVSDPNNV NIGPQRLLHS LPEETQHIVG
720 RMIDLAPACR GNIEEIMEDP WIRSIDMCHL VEDGLSFKVV RGEDHHHTQV DQSEAHIAGL
780 EKKKKKQNNQ
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
67185
Vandenbol M.,Jauniaux J.-C.,Grenson M.
The Saccharomyces cerevisiae NPR1 gene required for the activity of ammonia-sensitive amino acid permeases encodes a protein kinase homologue.
Mol. Gen. Genet.
222
393-399
1990
67186
Philippsen P.,Kleine K.,Poehlmann R.,Duesterhoeft A.,Hamberg K.,Hegemann J.H.,Obermaier B.,Urrestarazu L.A.,Aert R.,Albermann K.,Altmann R.,Andre B.,Baladron V.,Ballesta J.P.G.,Becam A.-M.,Beinhauer J.D.,Boskovic J.,Buitrago M.J.,Bussereau F.,Coster F.,Crouzet M.,D'Angelo M.,Dal Pero F.,De Antoni A.,del Rey F.,Doignon F.,Domdey H.,Dubois E.,Fiedler T.A.,Fleig U.,Floeth M.,Fritz C.,Gaillardin C.,Garcia-Cantalejo J.M.,Glansdorff N.,Goffeau A.,Gueldener U.,Herbert C.J.,Heumann K.,Heuss-Neitzel D.,Hilbert H.,Hinni K.,Iraqui Houssaini I.,Jacquet M.,Jimenez A.,Jonniaux J.-L.,Karpfinger-Hartl L.,Lanfranchi G.,Lepingle A.,Levesque H.,Lyck R.,Maftahi M.,Mallet L.,Maurer C.T.C.,Messenguy F.,Mewes H.-W.,Moestl D.,Nasr F.,Nicaud J.-M.,Niedenthal R.K.,Pandolfo D.,Pierard A.,Piravandi E.,Planta R.J.,Pohl T.M.,Purnelle B.,Rebischung C.,Remacha M.A.,Revuelta J.L.,Rinke M.,Saiz J.E.,Sartorello F.,Scherens B.,Sen-Gupta M.,Soler-Mira A.,Urbanus J.H.M.,Valle G.,Van Dyck L.,Verhasselt P.,Vierendeels F.,Vissers S.,Voet M.,Volckaert G.,Wach A.,Wambutt R.,Wedler H.,Zollner A.,Hani J.
The nucleotide sequence of Saccharomyces cerevisiae chromosome XIV and its evolutionary implications.
Nature
387
93-98
1997
67187
Engel S.R.,Dietrich F.S.,Fisk D.G.,Binkley G.,Balakrishnan R.,Costanzo M.C.,Dwight S.S.,Hitz B.C.,Karra K.,Nash R.S.,Weng S.,Wong E.D.,Lloyd P.,Skrzypek M.S.,Miyasato S.R.,Simison M.,Cherry J.M.
The reference genome sequence of Saccharomyces cerevisiae: Then and now.
G3 (Bethesda)
4
389-398
2014
67188
Gander S.,Bonenfant D.,Altermatt P.,Martin D.E.,Hauri S.,Moes S.,Hall M.N.,Jenoe P.
Identification of the rapamycin-sensitive phosphorylation sites within the Ser/Thr-rich domain of the yeast Npr1 protein kinase.
Rapid Commun. Mass Spectrom.
22
3743-3753
2008
67189
Grenson M.
Study of the positive control of the general amino-acid permease and other ammonia-sensitive uptake systems by the product of the NPR1 gene in the yeast Saccharomyces cerevisiae.
Eur. J. Biochem.
133
141-144
1983
67190
Schmidt A.,Beck T.,Koller A.,Kunz J.,Hall M.N.
The TOR nutrient signalling pathway phosphorylates NPR1 and inhibits turnover of the tryptophan permease.
EMBO J.
17
6924-6931
1998
67191
De Craene J.-O.,Soetens O.,Andre B.
The Npr1 kinase controls biosynthetic and endocytic sorting of the yeast Gap1 permease.
J. Biol. Chem.
276
43939-43948
2001
67192
Jacinto E.,Guo B.,Arndt K.T.,Schmelzle T.,Hall M.N.
TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway.
Mol. Cell
8
1017-1026
2001
67193
Ghaemmaghami S.,Huh W.-K.,Bower K.,Howson R.W.,Belle A.,Dephoure N.,O'Shea E.K.,Weissman J.S.
Global analysis of protein expression in yeast.
Nature
425
737-741
2003
67194
Crespo J.L.,Helliwell S.B.,Wiederkehr C.,Demougin P.,Fowler B.,Primig M.,Hall M.N.
NPR1 kinase and RSP5-BUL1/2 ubiquitin ligase control GLN3-dependent transcription in Saccharomyces cerevisiae.
J. Biol. Chem.
279
37512-37517
2004
67195
Feller A.,Boeckstaens M.,Marini A.-M.,Dubois E.
Transduction of the nitrogen signal activating Gln3-mediated transcription is independent of Npr1 kinase and Rsp5-Bul1/2 ubiquitin ligase in Saccharomyces cerevisiae.
J. Biol. Chem.
281
28546-28554
2006
67196
Tate J.J.,Rai R.,Cooper T.G.
Ammonia-specific regulation of Gln3 localization in Saccharomyces cerevisiae by protein kinase Npr1.
J. Biol. Chem.
281
28460-28469
2006
67197
Li X.,Gerber S.A.,Rudner A.D.,Beausoleil S.A.,Haas W.,Villen J.,Elias J.E.,Gygi S.P.
Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae.
J. Proteome Res.
6
1190-1197
2007
67198
Boeckstaens M.,Andre B.,Marini A.M.
The yeast ammonium transport protein Mep2 and its positive regulator, the Npr1 kinase, play an important role in normal and pseudohyphal growth on various nitrogen media through retrieval of excreted ammonium.
Mol. Microbiol.
64
534-546
2007
67199
Albuquerque C.P.,Smolka M.B.,Payne S.H.,Bafna V.,Eng J.,Zhou H.
A multidimensional chromatography technology for in-depth phosphoproteome analysis.
Mol. Cell. Proteomics
7
1389-1396
2008
67200
Holt L.J.,Tuch B.B.,Villen J.,Johnson A.D.,Gygi S.P.,Morgan D.O.
Global analysis of Cdk1 substrate phosphorylation sites provides insights into evolution.
Science
325
1682-1686
2009