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Sequence of TM10C_HUMAN

EC Number:2.1.1.218

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
tRNA (adenine9-N1)-methyltransferase
Q7L0Y3
Homo sapiens
403
47347
Reaction
S-adenosyl-L-methionine + adenine9 in tRNA = S-adenosyl-L-homocysteine + N1-methyladenine9 in tRNA
Other sequences found for EC No. 2.1.1.218

General information:

Sequence
show sequence in fasta format
  0 MAAFLKMSVS VNFFRPFTRF LVPFTLHRKR NNLTILQRYM SSKIPAVTYP KNESTPPSEE
 60 LELDKWKTTM KSSVQEECVS TISSSKDEDP LAATREFIEM WRLLGREVPE HITEEELKTL
120 MECVSNTAKK KYLKYLYTKE KVKKARQIKK EMKAAAREEA KNIKLLETTE EDKQKNFLFL
180 RLWDRNMDIA MGWKGAQAMQ FGQPLVFDMA YENYMKRKEL QNTVSQLLES EGWNRRNVDP
240 FHIYFCNLKI DGALHRELVK RYQEKWDKLL LTSTEKSHVD LFPKDSIIYL TADSPNVMTT
300 FRHDKVYVIG SFVDKSMQPG TSLAKAKRLN LATECLPLDK YLQWEIGNKN LTLDQMIRIL
360 LCLKNNGNWQ EALQFVPKRK HTGFLEISQH SQEFINRLKK AKT
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
746713
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
746715
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
746716
Scanlan M.J.,Gordan J.D.,Williamson B.,Stockert E.,Bander N.H.,Jongeneel C.V.,Gure A.O.,Jaeger D.,Jaeger E.,Knuth A.,Chen Y.-T.,Old L.J.
Antigens recognized by autologous antibody in patients with renal-cell carcinoma.
Int. J. Cancer
83
456-464
1999
746717
Lu Y.Y.,Li K.,Wang L.,Liu Y.,Wang Y.D.,Cheng J.,Zhang L.X.
Screening of the genes of hepatitis B virus preS2 interacting proteins.
Zhonghua Gan Zang Bing Za Zhi
11
8-10
2003
746718
Holzmann J.,Frank P.,Loeffler E.,Bennett K.L.,Gerner C.,Rossmanith W.
RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme.
Cell
135
462-474
2008
746719
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
746720
Brzezniak L.K.,Bijata M.,Szczesny R.J.,Stepien P.P.
Involvement of human ELAC2 gene product in 3' end processing of mitochondrial tRNAs.
RNA Biol.
8
616-626
2011
746721
Vilardo E.,Nachbagauer C.,Buzet A.,Taschner A.,Holzmann J.,Rossmanith W.
A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis.
Nucleic Acids Res.
40
11583-11593
2012
746722
Jourdain A.A.,Koppen M.,Wydro M.,Rodley C.D.,Lightowlers R.N.,Chrzanowska-Lightowlers Z.M.,Martinou J.C.
GRSF1 regulates RNA processing in mitochondrial RNA granules.
Cell Metab.
17
399-410
2013
746723
Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.
Toward a comprehensive characterization of a human cancer cell phosphoproteome.
J. Proteome Res.
12
260-271
2013
746724
Bogenhagen D.F.,Martin D.W.,Koller A.
Initial steps in RNA processing and ribosome assembly occur at mitochondrial DNA nucleoids.
Cell Metab.
19
618-629
2014
746725
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
746726
Metodiev M.D.,Thompson K.,Alston C.L.,Morris A.A.,He L.,Assouline Z.,Rio M.,Bahi-Buisson N.,Pyle A.,Griffin H.,Siira S.,Filipovska A.,Munnich A.,Chinnery P.F.,McFarland R.,Roetig A.,Taylor R.W.
Recessive mutations in TRMT10C cause defects in mitochondrial RNA processing and multiple respiratory chain deficiencies.
Am. J. Hum. Genet.
98
993-1000
2016
746727
Li X.,Xiong X.,Zhang M.,Wang K.,Chen Y.,Zhou J.,Mao Y.,Lv J.,Yi D.,Chen X.W.,Wang C.,Qian S.B.,Yi C.
Base-resolution mapping reveals distinct m1A methylome in nuclear- and mitochondrial-encoded transcripts.
Mol. Cell
0
0-0
2017
746728
Safra M.,Sas-Chen A.,Nir R.,Winkler R.,Nachshon A.,Bar-Yaacov D.,Erlacher M.,Rossmanith W.,Stern-Ginossar N.,Schwartz S.
The m(1)A landscape on cytosolic and mitochondrial mRNA at single-base resolution.
Nature
551
251-255
2017
746729
Reinhard L.,Sridhara S.,Haellberg B.M.
The MRPP1/MRPP2 complex is a tRNA-maturation platform in human mitochondria.
Nucleic Acids Res.
45
12469-12480
2017