Sequence of AFLC_ASPPU

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
noranthrone synthase
Q12053
Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1)
2109
230716
Reaction
7 malonyl-CoA + hexanoyl-[acyl-carrier protein] = 7 CoA + norsolorinic acid anthrone + [acyl-carrier protein] + 7 CO2 + 2 H2O
Sequences with same EC No.
Sequence
show sequence in fasta format
   0 MAQSRQLFLF GDQTADFVPK LRSLLSVQDS PILAAFLDQS HYVVRAQMLQ SMNTVDHKLA
  60 RTADLRQMVQ KYVDGKLTPA FRTALVCLCQ LGCFIREYEE SGNMYPQPSD SYVLGFCMGS
 120 LAAVAVSCSR SLSELLPIAV QTVLIAFRLG LCALEMRDRV DGCSDDRGDP WSTIVWGLDP
 180 QQARDQIEVF CRTTNVPQTR RPWISCISKN AITLSGSPST LRAFCAMPQM AQHRTAPIPI
 240 CLPAHNGALF TQADITTILD TTPTTPWEQL PGQIPYISHV TGNVVQTSNY RDLIEVALSE
 300 TLLEQVRLDL VETGLPRLLQ SRQVKSVTIV PFLTRMNETM SNILPDSFIS TETRTDTGRA
 360 IPASGRPGAG KCKLAIVSMS GRFPESPTTE SFWDLLYKGL DVCKEVPRRR WDINTHVDPS
 420 GKARNKGATK WGCWLDFSGD FDPRFFGISP KEAPQMDPAQ RMALMSTYEA MERAGLVPDT
 480 TPSTQRDRIG VFHGVTSNDW METNTAQNID TYFITGGNRG FIPGRINFCF EFAGPSYTND
 540 TACSSSLAAI HLACNSLWRG DCDTAVAGGT NMIYTPDGHT GLDKGFFLSR TGNCKPYDDK
 600 ADGYCRAEGV GTVFIKRLED ALADNDPILG VILDAKTNHS AMSESMTRPH VGAQIDNMTA
 660 ALNTTGLHPN DFSYIEMHGT GTQVGDAVEM ESVLSVFAPS ETARKADQPL FVGSAKANVG
 720 HGEGVSGVTS LIKVLMMMQH DTIPPHCGIK PGSKINRNFP DLGARNVHIA FEPKPWPRTH
 780 TPRRVLINNF SAAGGNTALI VEDAPERHWP TEKDPRSSHI VALSAHVGAS MKTNLERLHQ
 840 YLLKNPHTDL AQLSYTTTAR RWHYLHRVSV TGASVEEVTR KLEMAIQNGD GVSRPKSKPK
 900 ILFAFTGQGS QYATMGKQVY DAYPSFREDL EKFDRLAQSH GFPSFLHVCT SPKGDVEEMA
 960 PVVVQLAITC LQMALTNLMT SFGIRPDVTV GHSLGEFAAL YAAGVLSASD VVYLVGQRAE
1020 LLQERCQRGT HAMLAVKATP EALSQWIQDH DCEVACINGP EDTVLSGTTK NVAEVQRAMT
1080 DNGIKCTLLK LPFAFHSAQV QPILDDFEAL AQGATFAKPQ LLILSPLLRT EIHEQGVVTP
1140 SYVAQHCRHT VDMAQALRSA REKGLIDDKT LVIELGPKPL ISGMVKMTLG DKISTLPTLA
1200 PNKAIWPSLQ KILTSVYTGG WDINWKKYHA PFASSQKVVD LPSYGWDLKD YYIPYQGDWC
1260 LHRHQQDCKC AAPGHEIKTA DYQVPPESTP HRPSKLDPSK EAFPEIKTTT TLHRVVEETT
1320 KPLGATLVVE TDISRKDVNG LARGHLVDGI PLCTPSFYAD IAMQVGQYSM QRLRAGHPGA
1380 GAIDGLVDVS DMVVDKALVP HGKGPQLLRT TLTMEWPPKA AATTRSAKVK FATYFADGKL
1440 DTEHASCTVR FTSDAQLKSL RRSVSEYKTH IRQLHDGHAK GQFMRYNRKT GYKLMSSMAR
1500 FNPDYMLLDY LVLNEAENEA ASGVDFSLGS SEGTFAAHPA HVDAITQVAG FAMNANDNVD
1560 IEKQVYVNHG WDSFQIYQPL DNSKSYQVYT KMGQAKENDL VHGDVVVLDG EQIVAFFRGL
1620 TLRSVPRGAL RVVLQTTVKK ADRQLGFKTM PSPPPPTTTM PISPYKPANT QVSSQAIPAE
1680 ATHSHTPPQP KHSPVPETAG SAPAAKGVGV SNEKLDAVMR VVSEESGIAL EELTDDSNFA
1740 DMGIDSLSSM VIGSRFREDL GLDLGPEFSL FIDCTTVRAL KDFMLGSGDA GSGSNVEDPP
1800 PSATPGINPE TDWSSSASDS IFASEDHGHS SESGADTGSP PALDLKPYCR PSTSVVLQGL
1860 PMVARKTLFM LPDGGGSAFS YASLPRLKSD TAVVGLNCPY ARDPENMNCT HGAMIESFCN
1920 EIRRRQPRGP YHLGGWSSGG AFAYVVAEAL VNQGEEVHSL IIIDAPIPQA MEQLPRAFYE
1980 HCNSIGLFAT QPGASPDGST EPPSYLIPHF TAVVDVMLDY KLAPLHARRM PKVGIVWAAD
2040 TVMDERDAPK MKGMHFMIQK RTEFGPDGWD TIMPGASFDI VRADGANHFT LMQKEHVSII
2100 SDLIDRVMA
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
744992
Feng G.H.,Leonard T.J.
Characterization of the polyketide synthase gene (pksL1) required for aflatoxin biosynthesis in Aspergillus parasiticus.
J. Bacteriol.
177
6246-6254
1995
744993
Yu J.,Bhatnagar D.,Cleveland T.E.
Completed sequence of aflatoxin pathway gene cluster in Aspergillus parasiticus.
FEBS Lett.
564
126-130
2004
744995
Skory C.D.,Chang P.K.,Cary J.,Linz J.E.
Isolation and characterization of a gene from Aspergillus parasiticus associated with the conversion of versicolorin A to sterigmatocystin in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
58
3527-3537
1992
744996
Keller N.P.,Dischinger H.C. Jr.,Bhatnager D.,Cleveland T.E.,Ullah A.H.J.
Purification of a 40-kilodalton methyltransferase active in the aflatoxin biosynthetic pathway.
Appl. Environ. Microbiol.
59
479-484
1993
744997
Yabe K.,Matsuyama Y.,Ando Y.,Nakajima H.,Hamasaki T.
Stereochemistry during aflatoxin biosynthesis: conversion of norsolorinic acid to averufin.
Appl. Environ. Microbiol.
59
2486-2492
1993
744998
Yabe K.,Hamasaki T.
Stereochemistry during aflatoxin biosynthesis: cyclase reaction in the conversion of versiconal to versicolorin B and racemization of versiconal hemiacetal acetate.
Appl. Environ. Microbiol.
59
2493-2500
1993
744999
Chang P.K.,Cary J.W.,Yu J.,Bhatnagar D.,Cleveland T.E.
The Aspergillus parasiticus polyketide synthase gene pksA, a homolog of Aspergillus nidulans wA, is required for aflatoxin B1 biosynthesis.
Mol. Gen. Genet.
248
270-277
1995
745000
Motomura M.,Chihaya N.,Shinozawa T.,Hamasaki T.,Yabe K.
Cloning and characterization of the O-methyltransferase I gene (dmtA) from Aspergillus parasiticus associated with the conversions of demethylsterigmatocystin to sterigmatocystin and dihydrodemethylsterigmatocystin to dihydrosterigmatocystin in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
65
4987-4994
1999
745001
Zhou R.,Linz J.E.
Enzymatic function of the nor-1 protein in aflatoxin biosynthesis in Aspergillus parasiticus.
Appl. Environ. Microbiol.
65
5639-5641
1999
745002
Chang P.K.,Yu J.,Ehrlich K.C.,Boue S.M.,Montalbano B.G.,Bhatnagar D.,Cleveland T.E.
adhA in Aspergillus parasiticus is involved in conversion of 5'-hydroxyaverantin to averufin.
Appl. Environ. Microbiol.
66
4715-4719
2000
745003
Hitchman T.S.,Schmidt E.W.,Trail F.,Rarick M.D.,Linz J.E.,Townsend C.A.
Hexanoate synthase, a specialized type I fatty acid synthase in aflatoxin B1 biosynthesis.
Bioorg. Chem.
29
293-307
2001
745004
Udwary D.W.,Casillas L.K.,Townsend C.A.
Synthesis of 11-hydroxyl O-methylsterigmatocystin and the role of a cytochrome P-450 in the final step of aflatoxin biosynthesis.
J. Am. Chem. Soc.
124
5294-5303
2002
745005
Yu J.,Chang P.K.,Ehrlich K.C.,Cary J.W.,Bhatnagar D.,Cleveland T.E.,Payne G.A.,Linz J.E.,Woloshuk C.P.,Bennett J.W.
Clustered pathway genes in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
70
1253-1262
2004
745006
Ehrlich K.C.,Chang P.K.,Yu J.,Cotty P.J.
Aflatoxin biosynthesis cluster gene cypA is required for G aflatoxin formation.
Appl. Environ. Microbiol.
70
6518-6524
2004
745007
Sakuno E.,Wen Y.,Hatabayashi H.,Arai H.,Aoki C.,Yabe K.,Nakajima H.
Aspergillus parasiticus cyclase catalyzes two dehydration steps in aflatoxin biosynthesis.
Appl. Environ. Microbiol.
71
2999-3006
2005
745008
Ehrlich K.C.,Montalbano B.,Boue S.M.,Bhatnagar D.
An aflatoxin biosynthesis cluster gene encodes a novel oxidase required for conversion of versicolorin a to sterigmatocystin.
Appl. Environ. Microbiol.
71
8963-8965
2005
745009
Henry K.M.,Townsend C.A.
Ordering the reductive and cytochrome P450 oxidative steps in demethylsterigmatocystin formation yields general insights into the biosynthesis of aflatoxin and related fungal metabolites.
J. Am. Chem. Soc.
127
3724-3733
2005
745010
Cary J.W.,Ehrlich K.C.,Bland J.M.,Montalbano B.G.
The aflatoxin biosynthesis cluster gene, aflX, encodes an oxidoreductase involved in conversion of versicolorin A to demethylsterigmatocystin.
Appl. Environ. Microbiol.
72
1096-1101
2006
745011
Ma Y.,Smith L.H.,Cox R.J.,Beltran-Alvarez P.,Arthur C.J.,Simpson F.R.S.T.J.
Catalytic relationships between type I and type II iterative polyketide synthases: The Aspergillus parasiticus norsolorinic acid synthase.
ChemBioChem
7
1951-1958
2006
745012
Cai J.,Zeng H.,Shima Y.,Hatabayashi H.,Nakagawa H.,Ito Y.,Adachi Y.,Nakajima H.,Yabe K.
Involvement of the nadA gene in formation of G-group aflatoxins in Aspergillus parasiticus.
Fungal Genet. Biol.
45
1081-1093
2008
745013
Crawford J.M.,Thomas P.M.,Scheerer J.R.,Vagstad A.L.,Kelleher N.L.,Townsend C.A.
Deconstruction of iterative multidomain polyketide synthase function.
Science
320
243-246
2008
745014
Jahanshiri Z.,Shams-Ghahfarokhi M.,Allameh A.,Razzaghi-Abyaneh M.
Effect of curcumin on Aspergillus parasiticus growth and expression of major genes involved in the early and late stages of aflatoxin biosynthesis.
Iran. J. Public Health
41
72-79
2012
745015
Wattana-amorn P.,Williams C.,Ploskon E.,Cox R.J.,Simpson T.J.,Crosby J.,Crump M.P.
Solution structure of an acyl carrier protein domain from a fungal type I polyketide synthase.
Biochemistry
49
2186-2193
2010
745016
Crawford J.M.,Korman T.P.,Labonte J.W.,Vagstad A.L.,Hill E.A.,Kamari-Bidkorpeh O.,Tsai S.C.,Townsend C.A.
Structural basis for biosynthetic programming of fungal aromatic polyketide cyclization.
Nature
461
1139-1143
2009
745017
Korman T.P.,Crawford J.M.,Labonte J.W.,Newman A.G.,Wong J.,Townsend C.A.,Tsai S.C.
Structure and function of an iterative polyketide synthase thioesterase domain catalyzing Claisen cyclization in aflatoxin biosynthesis.
Proc. Natl. Acad. Sci. U.S.A.
107
6246-6251
2010