Sequence of SHIP1_HUMAN
EC Number:3.1.3.36
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate
Other sequences found for EC No. 3.1.3.36
General information:
Sequence
0 MVPCWNHGNI TRSKAEELLS RTGKDGSFLV RASESISRAY ALCVLYRNCV YTYRILPNED
60 DKFTVQASEG VSMRFFTKLD QLIEFYKKEN MGLVTHLQYP VPLEEEDTGD DPEEDTVESV
120 VSPPELPPRN IPLTASSCEA KEVPFSNENP RATETSRPSL SETLFQRLQS MDTSGLPEEH
180 LKAIQDYLST QLAQDSEFVK TGSSSLPHLK KLTTLLCKEL YGEVIRTLPS LESLQRLFDQ
240 QLSPGLRPRP QVPGEANPIN MVSKLSQLTS LLSSIEDKVK ALLHEGPESP HRPSLIPPVT
300 FEVKAESLGI PQKMQLKVDV ESGKLIIKKS KDGSEDKFYS HKKILQLIKS QKFLNKLVIL
360 VETEKEKILR KEYVFADSKK REGFCQLLQQ MKNKHSEQPE PDMITIFIGT WNMGNAPPPK
420 KITSWFLSKG QGKTRDDSAD YIPHDIYVIG TQEDPLSEKE WLEILKHSLQ EITSVTFKTV
480 AIHTLWNIRI VVLAKPEHEN RISHICTDNV KTGIANTLGN KGAVGVSFMF NGTSLGFVNS
540 HLTSGSEKKL RRNQNYMNIL RFLALGDKKL SPFNITHRFT HLFWFGDLNY RVDLPTWEAE
600 TIIQKIKQQQ YADLLSHDQL LTERREQKVF LHFEEEEITF APTYRFERLT RDKYAYTKQK
660 ATGMKYNLPS WCDRVLWKSY PLVHVVCQSY GSTSDIMTSD HSPVFATFEA GVTSQFVSKN
720 GPGTVDSQGQ IEFLRCYATL KTKSQTKFYL EFHSSCLESF VKSQEGENEE GSEGELVVKF
780 GETLPKLKPI ISDPEYLLDQ HILISIKSSD SDESYGEGCI ALRLEATETQ LPIYTPLTHH
840 GELTGHFQGE IKLQTSQGKT REKLYDFVKT ERDESSGPKT LKSLTSHDPM KQWEVTSRAP
900 PCSGSSITEI INPNYMGVGP FGPPMPLHVK QTLSPDQQPT AWSYDQPPKD SPLGPCRGES
960 PPTPPGQPPI SPKKFLPSTA NRGLPPRTQE SRPSDLGKNA GDTLPQEDLP LTKPEMFENP
1020 LYGSLSSFPK PAPRKDQESP KMPRKEPPPC PEPGILSPSI VLTKAQEADR GEGPGKQVPA
1080 PRLRSFTCSS SAEGRAAGGD KSQGKPKTPV SSQAPVPAKR PIKPSRSEIN QQTPPTPTPR
1140 PPLPVKSPAV LHLQHSKGRD YRDNTELPHH GKHRPEEGPP GPLGRTAMQ
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
736816
Drayer A.L.,Pesesse X.,De Smedt F.,Woscholski R.,Parker P.,Erneux C.
Cloning and expression of a human placenta inositol 1,3,4,5-tetrakisphosphate and phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase.
Biochem. Biophys. Res. Commun.
225
243-249
1996
736817
Ware M.D.,Rosten P.,Damen J.E.,Liu L.,Humphries R.K.,Krystal G.
Cloning and characterization of human SHIP, the 145-kD inositol 5-phosphatase that associates with SHC after cytokine stimulation.
Blood
88
2833-2840
1996
736818
Kavanaugh W.M.,Pot D.A.,Chin S.M.,Deuter-Reinhard M.,Jefferson A.B.,Norris F.A.,Masiarz F.R.,Cousens L.S.,Majerus P.W.,Williams L.T.
Multiple forms of an inositol polyphosphate 5-phosphatase form signaling complexes with Shc and Grb2.
Curr. Biol.
6
438-445
1996
736819
Geier S.J.,Algate P.A.,Carlberg K.,Flowers D.,Friedman C.,Trask B.,Rohrschneider L.R.
The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood.
Blood
89
1876-1885
1997
736820
Odai H.,Sasaki K.,Iwamatsu A.,Nakamoto T.,Ueno H.,Yamagata T.,Mitani K.,Yazaki Y.,Hirai H.
Purification and molecular cloning of SH2- and SH3-containing inositol polyphosphate-5-phosphatase, which is involved in the signaling pathway of granulocyte-macrophage colony-stimulating factor, erythropoietin, and Bcr-Abl.
Blood
89
2745-2756
1997
736821
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
736822
Mikhalap S.V.,Shlapatska L.M.,Berdova A.G.,Law C.L.,Clark E.A.,Sidorenko S.P.
CDw150 associates with src-homology 2-containing inositol phosphatase and modulates CD95-mediated apoptosis.
J. Immunol.
162
5719-5727
1999
736823
Dunant N.M.,Wisniewski D.,Strife A.,Clarkson B.,Resh M.D.
The phosphatidylinositol polyphosphate 5-phosphatase SHIP1 associates with the dok1 phosphoprotein in bcr-Abl transformed cells.
Cell. Signal.
12
317-326
2000
736824
Kisseleva M.V.,Wilson M.P.,Majerus P.W.
The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase.
J. Biol. Chem.
275
20110-20116
2000
736825
Freeburn R.W.,Wright K.L.,Burgess S.J.,Astoul E.,Cantrell D.A.,Ward S.G.
Evidence that SHIP-1 contributes to phosphatidylinositol 3,4,5-trisphosphate metabolism in T lymphocytes and can regulate novel phosphoinositide 3-kinase effectors.
J. Immunol.
169
5441-5450
2002
736826
Rush J.,Moritz A.,Lee K.A.,Guo A.,Goss V.L.,Spek E.J.,Zhang H.,Zha X.-M.,Polakiewicz R.D.,Comb M.J.
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
Nat. Biotechnol.
23
94-101
2005
736827
Vaillancourt M.,Levasseur S.,Tremblay M.-L.,Marois L.,Rollet-Labelle E.,Naccache P.H.
The Src homology 2-containing inositol 5-phosphatase 1 (SHIP1) is involved in CD32a signaling in human neutrophils.
Cell. Signal.
18
2022-2032
2006
736828
Kochi Y.,Myouzen K.,Yamada R.,Suzuki A.,Kurosaki T.,Nakamura Y.,Yamamoto K.
FCRL3, an autoimmune susceptibility gene, has inhibitory potential on B-cell receptor-mediated signaling.
J. Immunol.
183
5502-5510
2009
736829
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
736830
Kulemzin S.V.,Zamoshnikova A.Y.,Yurchenko M.Y.,Vitak N.Y.,Najakshin A.M.,Fayngerts S.A.,Chikaev N.A.,Reshetnikova E.S.,Kashirina N.M.,Peclo M.M.,Rutkevich P.N.,Shevelev A.Y.,Yanushevskaya E.V.,Baranov K.O.,Mamonkin M.,Vlasik T.N.,Sidorenko S.P.,Taranin A.V.,Mechetina L.V.
FCRL6 receptor: expression and associated proteins.
Immunol. Lett.
134
174-182
2011
736831
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
736833
Luo J.-M.,Yoshida H.,Komura S.,Ohishi N.,Pan L.,Shigeno K.,Hanamura I.,Miura K.,Iida S.,Ueda R.,Naoe T.,Akao Y.,Ohno R.,Ohnishi K.
Possible dominant-negative mutation of the SHIP gene in acute myeloid leukemia.
Leukemia
17
1-8
2003
