Sequence of POLG_ZIKV
EC Number:2.7.7.48
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
nucleoside triphosphate + RNAn = diphosphate + RNAn+1
Other sequences found for EC No. 2.7.7.48
General information:
Sequence
0 MKNPKEEIRR IRIVNMLKRG VARVNPLGGL KRLPAGLLLG HGPIRMVLAI LAFLRFTAIK
60 PSLGLINRWG SVGKKEAMEI IKKFKKDLAA MLRIINARKE RKRRGADTSI GIIGLLLTTA
120 MAAEITRRGS AYYMYLDRSD AGKAISFATT LGVNKCHVQI MDLGHMCDAT MSYECPMLDE
180 GVEPDDVDCW CNTTSTWVVY GTCHHKKGEA RRSRRAVTLP SHSTRKLQTR SQTWLESREY
240 TKHLIKVENW IFRNPGFALV AVAIAWLLGS STSQKVIYLV MILLIAPAYS IRCIGVSNRD
300 FVEGMSGGTW VDVVLEHGGC VTVMAQDKPT VDIELVTTTV SNMAEVRSYC YEASISDMAS
360 DSRCPTQGEA YLDKQSDTQY VCKRTLVDRG WGNGCGLFGK GSLVTCAKFT CSKKMTGKSI
420 QPENLEYRIM LSVHGSQHSG MIGYETDEDR AKVEVTPNSP RAEATLGGFG SLGLDCEPRT
480 GLDFSDLYYL TMNNKHWLVH KEWFHDIPLP WHAGADTGTP HWNNKEALVE FKDAHAKRQT
540 VVVLGSQEGA VHTALAGALE AEMDGAKGRL FSGHLKCRLK MDKLRLKGVS YSLCTAAFTF
600 TKVPAETLHG TVTVEVQYAG TDGPCKIPVQ MAVDMQTLTP VGRLITANPV ITESTENSKM
660 MLELDPPFGD SYIVIGVGDK KITHHWHRSG STIGKAFEAT VRGAKRMAVL GDTAWDFGSV
720 GGVFNSLGKG IHQIFGAAFK SLFGGMSWFS QILIGTLLVW LGLNTKNGSI SLTCLALGGV
780 MIFLSTAVSA DVGCSVDFSK KETRCGTGVF IYNDVEAWRD RYKYHPDSPR RLAAAVKQAW
840 EEGICGISSV SRMENIMWKS VEGELNAILE ENGVQLTVVV GSVKNPMWRG PQRLPVPVNE
900 LPHGWKAWGK SYFVRAAKTN NSFVVDGDTL KECPLEHRAW NSFLVEDHGF GVFHTSVWLK
960 VREDYSLECD PAVIGTAVKG REAAHSDLGY WIESEKNDTW RLKRAHLIEM KTCEWPKSHT
1020 LWTDGVEESD LIIPKSLAGP LSHHNTREGY RTQVKGPWHS EELEIRFEEC PGTKVYVEET
1080 CGTRGPSLRS TTASGRVIEE WCCRECTMPP LSFRAKDGCW YGMEIRPRKE PESNLVRSMV
1140 TAGSTDHMDH FSLGVLVILL MVQEGLKKRM TTKIIMSTSM AVLVVMILGG FSMSDLAKLV
1200 ILMGATFAEM NTGGDVAHLA LVAAFKVRPA LLVSFIFRAN WTPRESMLLA LASCLLQTAI
1260 SALEGDLMVL INGFALAWLA IRAMAVPRTD NIALPILAAL TPLARGTLLV AWRAGLATCG
1320 GIMLLSLKGK GSVKKNLPFV MALGLTAVRV VDPINVVGLL LLTRSGKRSW PPSEVLTAVG
1380 LICALAGGFA KADIEMAGPM AAVGLLIVSY VVSGKSVDMY IERAGDITWE KDAEVTGNSP
1440 RLDVALDESG DFSLVEEDGP PMREIILKVV LMAICGMNPI AIPFAAGAWY VYVKTGKRSG
1500 ALWDVPAPKE VKKGETTDGV YRVMTRRLLG STQVGVGVMQ EGVFHTMWHV TKGAALRSGE
1560 GRLDPYWGDV KQDLVSYCGP WKLDAAWDGL SEVQLLAVPP GERARNIQTL PGIFKTKDGD
1620 IGAVALDYPA GTSGSPILDK CGRVIGLYGN GVVIKNGSYV SAITQGKREE ETPVECFEPS
1680 MLKKKQLTVL DLHPGAGKTR RVLPEIVREA IKKRLRTVIL APTRVVAAEM EEALRGLPVR
1740 YMTTAVNVTH SGTEIVDLMC HATFTSRLLQ PIRVPNYNLN IMDEAHFTDP SSIAARGYIS
1800 TRVEMGEAAA IFMTATPPGT RDAFPDSNSP IMDTEVEVPE RAWSSGFDWV TDHSGKTVWF
1860 VPSVRNGNEI AACLTKAGKR VIQLSRKTFE TEFQKTKNQE WDFVITTDIS EMGANFKADR
1920 VIDSRRCLKP VILDGERVIL AGPMPVTHAS AAQRRGRIGR NPNKPGDEYM YGGGCAETDE
1980 GHAHWLEARM LLDNIYLQDG LIASLYRPEA DKVAAIEGEF KLRTEQRKTF VELMKRGDLP
2040 VWLAYQVASA GITYTDRRWC FDGTTNNTIM EDSVPAEVWT KYGEKRVLKP RWMDARVCSD
2100 HAALKSFKEF AAGKRGAALG VMEALGTLPG HMTERFQEAI DNLAVLMRAE TGSRPYKAAA
2160 AQLPETLETI MLLGLLGTVS LGIFFVLMRN KGIGKMGFGM VTLGASAWLM WLSEIEPARI
2220 ACVLIVVFLL LVVLIPEPEK QRSPQDNQMA IIIMVAVGLL GLITANELGW LERTKNDIAH
2280 LMGRREEGAT MGFSMDIDLR PASAWAIYAA LTTLITPAVQ HAVTTSYNNY SLMAMATQAG
2340 VLFGMGKGMP FMHGDLGVPL LMMGCYSQLT PLTLIVAIIL LVAHYMYLIP GLQAAAARAA
2400 QKRTAAGIMK NPVVDGIVVT DIDTMTIDPQ VEKKMGQVLL IAVAISSAVL LRTAWGWGEA
2460 GALITAATST LWEGSPNKYW NSSTATSLCN IFRGSYLAGA SLIYTVTRNA GLVKRRGGGT
2520 GETLGEKWKA RLNQMSALEF YSYKKSGITE VCREEARRAL KDGVATGGHA VSRGSAKIRW
2580 LEERGYLQPY GKVVDLGCGR GGWSYYAATI RKVQEVRGYT KGGPGHEEPM LVQSYGWNIV
2640 RLKSGVDVFH MAAEPCDTLL CDIGESSSSP EVEETRTLRV LSMVGDWLEK RPGAFCIKVL
2700 CPYTSTMMET MERLQRRHGG GLVRVPLCRN STHEMYWVSG AKSNIIKSVS TTSQLLLGRM
2760 DGPRRPVKYE EDVNLGSGTR AVASCAEAPN MKIIGRRIER IRNEHAETWF LDENHPYRTW
2820 AYHGSYEAPT QGSASSLVNG VVRLLSKPWD VVTGVTGIAM TDTTPYGQQR VFKEKVDTRV
2880 PDPQEGTRQV MNIVSSWLWK ELGKRKRPRV CTKEEFINKV RSNAALGAIF EEEKEWKTAV
2940 EAVNDPRFWA LVDREREHHL RGECHSCVYN MMGKREKKQG EFGKAKGSRA IWYMWLGARF
3000 LEFEALGFLN EDHWMGRENS GGGVEGLGLQ RLGYILEEMN RAPGGKMYAD DTAGWDTRIS
3060 KFDLENEALI TNQMEEGHRT LALAVIKYTY QNKVVKVLRP AEGGKTVMDI ISRQDQRGSG
3120 QVVTYALNTF TNLVVQLIRN MEAEEVLEMQ DLWLLRKPEK VTRWLQSNGW DRLKRMAVSG
3180 DDCVVKPIDD RFAHALRFLN DMGKVRKDTQ EWKPSTGWSN WEEVPFCSHH FNKLYLKDGR
3240 SIVVPCRHQD ELIGRARVSP GAGWSIRETA CLAKSYAQMW QLLYFHRRDL RLMANAICSA
3300 VPVDWVPTGR TTWSIHGKGE WMTTEDMLMV WNRVWIEEND HMEDKTPVTK WTDIPYLGKR
3360 EDLWCGSLIG HRPRTTWAEN IKDTVNMVRR IIGDEEKYMD YLSTQVRYLG EEGSTPGVL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
714511
Kuno G.,Chang G.J.
Biological transmission of arboviruses: reexamination of and new insights into components, mechanisms, and unique traits as well as their evolutionary trends.
Clin. Microbiol. Rev.
18
608-637
2005
714512
Kuno G.,Chang G.J.
Full-length sequencing and genomic characterization of Bagaza, Kedougou, and Zika viruses.
Arch. Virol.
152
687-696
2007
714513
Rastogi M.,Sharma N.,Singh S.K.
Flavivirus NS1: a multifaceted enigmatic viral protein.
Virol. J.
13
131-131
2016
714514
Giri R.,Kumar D.,Sharma N.,Uversky V.N.
Intrinsically disordered side of the zika virus proteome.
Front. Cell. Infect. Microbiol.
6
144-144
2016
714515
Liang Q.,Luo Z.,Zeng J.,Chen W.,Foo S.S.,Lee S.A.,Ge J.,Wang S.,Goldman S.A.,Zlokovic B.V.,Zhao Z.,Jung J.U.
Zika virus NS4A and NS4B proteins deregulate Akt-mTOR signaling in human fetal neural stem cells to inhibit neurogenesis and induce autophagy.
Cell Stem Cell
19
663-671
2016
714516
Kumar A.,Hou S.,Airo A.M.,Limonta D.,Mancinelli V.,Branton W.,Power C.,Hobman T.C.
Zika virus inhibits type-I interferon production and downstream signaling.
EMBO Rep.
17
1766-1775
2016
714517
Grant A.,Ponia S.S.,Tripathi S.,Balasubramaniam V.,Miorin L.,Sourisseau M.,Schwarz M.C.,Sanchez-Seco M.P.,Evans M.J.,Best S.M.,Garcia-Sastre A.
Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling.
Cell Host Microbe
19
882-890
2016
714518
Yoon K.J.,Song G.,Qian X.,Pan J.,Xu D.,Rho H.S.,Kim N.S.,Habela C.,Zheng L.,Jacob F.,Zhang F.,Lee E.M.,Huang W.K.,Ringeling F.R.,Vissers C.,Li C.,Yuan L.,Kang K.,Kim S.,Yeo J.,Cheng Y.,Liu S.,Wen Z.,Qin C.F.,Wu Q.,Christian K.M.,Tang H.,Jin P.,Xu Z.,Qian J.,Zhu H.,Song H.,Ming G.L.
Zika-Virus-encoded NS2A disrupts mammalian cortical neurogenesis by degrading adherens junction proteins.
Cell Stem Cell
21
349-358
2017
714519
Theys K.,Libin P.,Dallmeier K.,Pineda-Pena A.C.,Vandamme A.M.,Cuypers L.,Abecasis A.B.
Zika genomics urgently need standardized and curated reference sequences.
PLoS Pathog.
13
0-0
2017
714520
Wu Y.,Liu Q.,Zhou J.,Xie W.,Chen C.,Wang Z.,Yang H.,Cui J.
Zika virus evades interferon-mediated antiviral response through the co-operation of multiple nonstructural proteins in vitro.
Cell Discov.
3
17006-17006
2017
714521
Shah P.S.,Link N.,Jang G.M.,Sharp P.P.,Zhu T.,Swaney D.L.,Johnson J.R.,Von Dollen J.,Ramage H.R.,Satkamp L.,Newton B.,Huettenhain R.,Petit M.J.,Baum T.,Everitt A.,Laufman O.,Tassetto M.,Shales M.,Stevenson E.,Iglesias G.N.,Shokat L.,Tripathi S.,Balasubramaniam V.,Webb L.G.,Aguirre S.,Willsey A.J.,Garcia-Sastre A.,Pollard K.S.,Cherry S.,Gamarnik A.V.,Marazzi I.,Taunton J.,Fernandez-Sesma A.,Bellen H.J.,Andino R.,Krogan N.J.
Comparative Flavivirus-Host Protein Interaction Mapping Reveals Mechanisms of Dengue and Zika Virus Pathogenesis.
Cell
175
1931-1945
2018
714522
Mishra P.M.,Uversky V.N.,Giri R.
Molecular recognition features in zika virus proteome.
J. Mol. Biol.
430
2372-2388
2018
714523
Ma L.,Li F.,Zhang J.W.,Li W.,Zhao D.M.,Wang H.,Hua R.H.,Bu Z.G.
Host Factor SPCS1 Regulates the Replication of Japanese Encephalitis Virus through Interactions with Transmembrane Domains of NS2B.
J. Virol.
92
0-0
2018
714524
Zheng Y.,Liu Q.,Wu Y.,Ma L.,Zhang Z.,Liu T.,Jin S.,She Y.,Li Y.P.,Cui J.
Zika virus elicits inflammation to evade antiviral response by cleaving cGAS via NS1-caspase-1 axis.
EMBO J.
37
0-0
2018
714525
Saw W.G.,Chan K.W.,Vasudevan S.G.,Grueber G.
Zika virus nonstructural protein 5 residue R681 is critical for dimer formation and enzymatic activity.
FEBS Lett.
593
1272-1291
2019
714526
Lundberg R.,Melen K.,Westenius V.,Jiang M.,Oesterlund P.,Khan H.,Vapalahti O.,Julkunen I.,Kakkola L.
Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon.
Viruses
11
0-0
2019
714527
Lin S.,Yang S.,He J.,Guest J.D.,Ma Z.,Yang L.,Pierce B.G.,Tang Q.,Zhang Y.J.
Zika virus NS5 protein antagonizes type I interferon production via blocking TBK1 activation.
Virology
527
180-187
2019
714528
Avila-Perez G.,Nogales A.,Park J.G.,Marquez-Jurado S.,Iborra F.J.,Almazan F.,Martinez-Sobrido L.
A natural polymorphism in Zika virus NS2A protein responsible of virulence in mice.
Sci. Rep.
9
19968-19968
2019
714529
Ngueyen T.T.N.,Kim S.J.,Lee J.Y.,Myoung J.
Zika Virus Proteins NS2A and NS4A Are Major Antagonists that Reduce IFN-beta Promoter Activity Induced by the MDA5/RIG-I Signaling Pathway.
J. Microbiol. Biotechnol.
29
1665-1674
2019
714530
Wu Y.,Yang X.,Yao Z.,Dong X.,Zhang D.,Hu Y.,Zhang S.,Lin J.,Chen J.,An S.,Ye H.,Zhang S.,Qiu Z.,He Z.,Huang M.,Wei G.,Zhu X.
C19orf66 interrupts Zika virus replication by inducing lysosomal degradation of viral NS3.
PLoS Negl. Trop. Dis.
14
0-0
2020
714531
Fajardo T.,Sanford T.J.,Mears H.V.,Jasper A.,Storrie S.,Mansur D.S.,Sweeney T.R.
The flavivirus polymerase NS5 regulates translation of viral genomic RNA.
Nucleic Acids Res.
48
5081-5093
2020
714532
Brown W.C.,Akey D.L.,Konwerski J.R.,Tarrasch J.T.,Skiniotis G.,Kuhn R.J.,Smith J.L.
Extended surface for membrane association in Zika virus NS1 structure.
Nat. Struct. Mol. Biol.
23
865-867
2016
714533
Zhang Z.,Li Y.,Loh Y.R.,Phoo W.W.,Hung A.W.,Kang C.,Luo D.
Crystal structure of unlinked NS2B-NS3 protease from Zika virus.
Science
354
1597-1600
2016
714534
Lei J.,Hansen G.,Nitsche C.,Klein C.D.,Zhang L.,Hilgenfeld R.
Crystal structure of Zika virus NS2B-NS3 protease in complex with a boronate inhibitor.
Science
353
503-505
2016
714535
Jain R.,Coloma J.,Garcia-Sastre A.,Aggarwal A.K.
Structure of the NS3 helicase from Zika virus.
Nat. Struct. Mol. Biol.
23
752-754
2016
714536
Godoy A.S.,Lima G.M.,Oliveira K.I.,Torres N.U.,Maluf F.V.,Guido R.V.,Oliva G.
Crystal structure of Zika virus NS5 RNA-dependent RNA polymerase.
Nat. Commun.
8
14764-14764
2017
714537
Bukrejewska M.,Derewenda U.,Radwanska M.,Engel D.A.,Derewenda Z.S.
Crystal structures of the methyltransferase and helicase from the ZIKA 1947 MR766 Uganda strain.
Acta Crystallogr. D
73
767-774
2017
714538
Upadhyay A.K.,Cyr M.,Longenecker K.,Tripathi R.,Sun C.,Kempf D.J.
Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.
Acta Crystallogr. F
73
116-122
2017
714539
Zhao B.,Yi G.,Du F.,Chuang Y.C.,Vaughan R.C.,Sankaran B.,Kao C.C.,Li P.
Structure and function of the Zika virus full-length NS5 protein.
Nat. Commun.
8
14762-14762
2017
714540
Li L.,Wang J.,Jia Z.,Shaw N.
Structural view of the helicase reveals that Zika virus uses a conserved mechanism for unwinding RNA.
Acta Crystallogr. F
74
205-213
2018
714541
Li Y.,Zhang Z.,Phoo W.W.,Loh Y.R.,Li R.,Yang H.Y.,Jansson A.E.,Hill J.,Keller T.H.,Nacro K.,Luo D.,Kang C.
Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.
Structure
26
555-564
2018
714542
Ng I.H.W.,Chan K.W.,Tan M.J.A.,Gwee C.P.,Smith K.M.,Jeffress S.J.,Saw W.G.,Swarbrick C.M.D.,Watanabe S.,Jans D.A.,Grueber G.,Forwood J.K.,Vasudevan S.G.
Zika Virus NS5 Forms Supramolecular Nuclear Bodies That Sequester Importin-alpha and Modulate the Host Immune and Pro-Inflammatory Response in Neuronal Cells.
ACS Infect. Dis.
5
932-948
2019
