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Sequence of PLD3_HUMAN

EC Number:3.1.16.1

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
spleen exonuclease
Q8IV08
Homo sapiens
490
54705
Reaction
exonucleolytic cleavage in the 5'- to 3'-direction to yield nucleoside 3'-phosphates
Other sequences found for EC No. 3.1.16.1

General information:

Sequence
show sequence in fasta format
  0 MKPKLMYQEL KVPAEEPANE LPMNEIEAWK AAEKKARWVL LVLILAVVGF GALMTQLFLW
 60 EYGDLHLFGP NQRPAPCYDP CEAVLVESIP EGLDFPNAST GNPSTSQAWL GLLAGAHSSL
120 DIASFYWTLT NNDTHTQEPS AQQGEEVLRQ LQTLAPKGVN VRIAVSKPSG PQPQADLQAL
180 LQSGAQVRMV DMQKLTHGVL HTKFWVVDQT HFYLGSANMD WRSLTQVKEL GVVMYNCSCL
240 ARDLTKIFEA YWFLGQAGSS IPSTWPRFYD TRYNQETPME ICLNGTPALA YLASAPPPLC
300 PSGRTPDLKA LLNVVDNARS FIYVAVMNYL PTLEFSHPHR FWPAIDDGLR RATYERGVKV
360 RLLISCWGHS EPSMRAFLLS LAALRDNHTH SDIQVKLFVV PADEAQARIP YARVNHNKYM
420 VTERATYIGT SNWSGNYFTE TAGTSLLVTQ NGRGGLRSQL EAIFLRDWDS PYSHDLDTSA
480 DSVGNACRLL
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
713465
Cao J.X.,Koop B.F.,Upton C.
A human homolog of the vaccinia virus HindIII K4L gene is a member of the phospholipase D superfamily.
Virus Res.
48
11-18
1997
713466
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
713467
Munck A.,Boehm C.,Seibel N.M.,Hashemol Hosseini Z.,Hampe W.
Hu-K4 is a ubiquitously expressed type 2 transmembrane protein associated with the endoplasmic reticulum.
FEBS J.
272
1718-1726
2005
713468
Chen R.,Jiang X.,Sun D.,Han G.,Wang F.,Ye M.,Wang L.,Zou H.
Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
J. Proteome Res.
8
651-661
2009
713469
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
713470
Osisami M.,Ali W.,Frohman M.A.
A role for phospholipase D3 in myotube formation.
PLoS ONE
7
0-0
2012
713471
Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.
An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
J. Proteomics
96
253-262
2014
713472
Cruchaga C.,Karch C.M.,Jin S.C.,Benitez B.A.,Cai Y.,Guerreiro R.,Harari O.,Norton J.,Budde J.,Bertelsen S.,Jeng A.T.,Cooper B.,Skorupa T.,Carrell D.,Levitch D.,Hsu S.,Choi J.,Ryten M.,Hardy J.,Ryten M.,Trabzuni D.,Weale M.E.,Ramasamy A.,Smith C.,Sassi C.,Bras J.,Gibbs J.R.,Hernandez D.G.,Lupton M.K.,Powell J.,Forabosco P.,Ridge P.G.,Corcoran C.D.,Tschanz J.T.,Norton M.C.,Munger R.G.,Schmutz C.,Leary M.,Demirci F.Y.,Bamne M.N.,Wang X.,Lopez O.L.,Ganguli M.,Medway C.,Turton J.,Lord J.,Braae A.,Barber I.,Brown K.,Passmore P.,Craig D.,Johnston J.,McGuinness B.,Todd S.,Heun R.,Kolsch H.,Kehoe P.G.,Hooper N.M.,Vardy E.R.,Mann D.M.,Pickering-Brown S.,Brown K.,Kalsheker N.,Lowe J.,Morgan K.,David Smith A.,Wilcock G.,Warden D.,Holmes C.,Pastor P.,Lorenzo-Betancor O.,Brkanac Z.,Scott E.,Topol E.,Morgan K.,Rogaeva E.,Singleton A.B.,Hardy J.,Kamboh M.I.,St George-Hyslop P.,Cairns N.,Morris J.C.,Kauwe J.S.,Goate A.M.
Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease.
Nature
505
550-554
2014
713473
Cacace R.,Van den Bossche T.,Engelborghs S.,Geerts N.,Laureys A.,Dillen L.,Graff C.,Thonberg H.,Chiang H.H.,Pastor P.,Ortega-Cubero S.,Pastor M.A.,Diehl-Schmid J.,Alexopoulos P.,Benussi L.,Ghidoni R.,Binetti G.,Nacmias B.,Sorbi S.,Sanchez-Valle R.,Llado A.,Gelpi E.,Almeida M.R.,Santana I.,Tsolaki M.,Koutroumani M.,Clarimon J.,Lleo A.,Fortea J.,de Mendonca A.,Martins M.,Borroni B.,Padovani A.,Matej R.,Rohan Z.,Vandenbulcke M.,Vandenberghe R.,De Deyn P.P.,Cras P.,van der Zee J.,Sleegers K.,Van Broeckhoven C.
Rare variants in PLD3 do not affect risk for early-onset Alzheimer disease in a European consortium cohort.
Hum. Mutat.
36
1226-1235
2015
713474
Lambert J.C.,Grenier-Boley B.,Bellenguez C.,Pasquier F.,Campion D.,Dartigues J.F.,Berr C.,Tzourio C.,Amouyel P.
PLD3 and sporadic Alzheimer's disease risk.
Nature
520
0-0
2015
713475
van der Lee S.J.,Holstege H.,Wong T.H.,Jakobsdottir J.,Bis J.C.,Chouraki V.,van Rooij J.G.,Grove M.L.,Smith A.V.,Amin N.,Choi S.H.,Beiser A.S.,Garcia M.E.,van Ijcken W.F.,Pijnenburg Y.A.,Louwersheimer E.,Brouwer R.W.,van den Hout M.C.,Oole E.,Eirkisdottir G.,Levy D.,Rotter J.I.,Emilsson V.,O'Donnell C.J.,Aspelund T.,Uitterlinden A.G.,Launer L.J.,Hofman A.,Boerwinkle E.,Psaty B.M.,DeStefano A.L.,Scheltens P.,Seshadri S.,van Swieten J.C.,Gudnason V.,van der Flier W.M.,Ikram M.A.,van Duijn C.M.
PLD3 variants in population studies.
Nature
520
0-0
2015
713476
Heilmann S.,Drichel D.,Clarimon J.,Fernandez V.,Lacour A.,Wagner H.,Thelen M.,Hernandez I.,Fortea J.,Alegret M.,Blesa R.,Mauleon A.,Roca M.R.,Kornhuber J.,Peters O.,Heun R.,Froelich L.,Huell M.,Heneka M.T.,Ruether E.,Riedel-Heller S.,Scherer M.,Wiltfang J.,Jessen F.,Becker T.,Tarraga L.,Boada M.,Maier W.,Lleo A.,Ruiz A.,Noethen M.M.,Ramirez A.
PLD3 in non-familial Alzheimer's disease.
Nature
520
0-0
2015
713477
Hooli B.V.,Lill C.M.,Mullin K.,Qiao D.,Lange C.,Bertram L.,Tanzi R.E.
PLD3 gene variants and Alzheimer's disease.
Nature
520
0-0
2015
713478
Cruchaga C.,Goate A.M.
Cruchaga & Goate reply.
Nature
520
0-0
2015
713479
Vaca Jacome A.S.,Rabilloud T.,Schaeffer-Reiss C.,Rompais M.,Ayoub D.,Lane L.,Bairoch A.,Van Dorsselaer A.,Carapito C.
N-terminome analysis of the human mitochondrial proteome.
Proteomics
15
2519-2524
2015
713480
Nibbeling E.A.R.,Duarri A.,Verschuuren-Bemelmans C.C.,Fokkens M.R.,Karjalainen J.M.,Smeets C.J.L.M.,de Boer-Bergsma J.J.,van der Vries G.,Dooijes D.,Bampi G.B.,van Diemen C.,Brunt E.,Ippel E.,Kremer B.,Vlak M.,Adir N.,Wijmenga C.,van de Warrenburg B.P.C.,Franke L.,Sinke R.J.,Verbeek D.S.
Exome sequencing and network analysis identifies shared mechanisms underlying spinocerebellar ataxia.
Brain
140
2860-2878
2017
713481
Fazzari P.,Horre K.,Arranz A.M.,Frigerio C.S.,Saito T.,Saido T.C.,De Strooper B.
PLD3 gene and processing of APP.
Nature
541
0-0
2017
713482
Gonzalez A.C.,Stroobants S.,Reisdorf P.,Gavin A.L.,Nemazee D.,Schwudke D.,D'Hooge R.,Saftig P.,Damme M.
PLD3 and spinocerebellar ataxia.
Brain
141
0-0
2018
713483
Mukadam A.S.,Breusegem S.Y.,Seaman M.N.J.
Analysis of novel endosome-to-Golgi retrieval genes reveals a role for PLD3 in regulating endosomal protein sorting and amyloid precursor protein processing.
Cell. Mol. Life Sci.
75
2613-2625
2018
713484
Gonzalez A.C.,Schweizer M.,Jagdmann S.,Bernreuther C.,Reinheckel T.,Saftig P.,Damme M.
Unconventional Trafficking of Mammalian Phospholipase D3 to Lysosomes.
Cell Rep.
22
1040-1053
2018