Sequence of OBLA_ASPCL
EC Number:4.2.3.145
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
ophiobolin F synthase
A1C8C3
Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)
718
81603
Reaction
(2E,6E,10E,14E)-geranylfarnesyl diphosphate + H2O = ophiobolin F + diphosphate
Other sequences found for EC No. 4.2.3.145
General information:
Sequence
0 MACKYSTLID SSLYDREGLC PGIDLRRHVA GELEEVGAFR AQEDWRRLVG PLPKPYAGLL
60 GPDFSFITGA VPECHPDRME IVAYALEFGF MHDDVIDTDV NHASLDEVGH TLDQSRTGKI
120 EDKGSDGKRQ MVTQIIREMM AIDPERAMTV AKSWASGVRH SSRRKEDTNF KALEQYIPYR
180 ALDVGYMLWH GLVTFGCAIT IPNEEEEEAK RLIIPALVQA SLLNDLFSFE KEKNDANVQN
240 AVLIVMNEHG CSEEEARDIL KKRIRLECAN YLRNVKETNA RADVSDELKR YINVMQYTLS
300 GNAAWSTNCP RYNGPTKFNE LQLLRSEHGL AKYPSRWSQE NRTSGLVEGD CHESKPNELK
360 RKRNGVSVDD EMRTNGTNGA KKPAHVSQPS TDSIVLEDMV QLARTCDLPD LSDTVILQPY
420 RYLTSLPSKG FRDQAIDSIN KWLKVPPKSV KMIKDVVKML HSASLMLDDL EDNSPLRRGK
480 PSTHSIYGMA QTVNSATYQY ITATDITAQL QNSETFHIFV EELQQLHVGQ SYDLYWTHNT
540 LCPTIAEYLK MVDMKTGGLF RMLTRMMIAE SPVVDKVPNS DMNLFSCLIG RFFQIRDDYQ
600 NLASADYAKA KGFAEDLDEG KYSFTLIHCI QTLESKPELA GEMMQLRAFL MKRRHEGKLS
660 QEAKQEVLVT MKKTESLQYT LSVLRELHSE LEKEVENLEA KFGEENFTLR VMLELLKV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
707010
Fedorova N.D.,Khaldi N.,Joardar V.S.,Maiti R.,Amedeo P.,Anderson M.J.,Crabtree J.,Silva J.C.,Badger J.H.,Albarraq A.,Angiuoli S.,Bussey H.,Bowyer P.,Cotty P.J.,Dyer P.S.,Egan A.,Galens K.,Fraser-Liggett C.M.,Haas B.J.,Inman J.M.,Kent R.,Lemieux S.,Malavazi I.,Orvis J.,Roemer T.,Ronning C.M.,Sundaram J.P.,Sutton G.,Turner G.,Venter J.C.,White O.R.,Whitty B.R.,Youngman P.,Wolfe K.H.,Goldman G.H.,Wortman J.R.,Jiang B.,Denning D.W.,Nierman W.C.
Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus.
PLoS Genet.
4
0-0
2008
707011
Chiba R.,Minami A.,Gomi K.,Oikawa H.
Identification of ophiobolin F synthase by a genome mining approach: a sesterterpene synthase from Aspergillus clavatus.
Org. Lett.
15
594-597
2013
707012
Narita K.,Chiba R.,Minami A.,Kodama M.,Fujii I.,Gomi K.,Oikawa H.
Multiple oxidative modifications in the ophiobolin biosynthesis: P450 oxidations found in genome mining.
Org. Lett.
18
1980-1983
2016
707013
Pemberton T.A.,Chen M.,Harris G.G.,Chou W.K.,Duan L.,Koeksal M.,Genshaft A.S.,Cane D.E.,Christianson D.W.
Exploring the influence of domain architecture on the catalytic function of diterpene synthases.
Biochemistry
56
2010-2023
2017
