Sequence of FHIT_HUMAN

adenylylsulfate-ammonia adenylyltransferase

P49789

147

16858

671410

Ohta M.,Inoue H.,Cotticelli M.G.,Kastury K.,Baffa R.,Palazzo J.,Siprashvili Z.,Mori M.,McCue P.,Druck T.,Croce C.M.,Huebner K.

The FHIT gene, spanning the chromosome 3p14.2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.

Cell

84

587-597

1996

671411

Druck T.,Hadaczek P.,Fu T.B.,Ohta M.,Siprashvili Z.,Baffa R.,Negrini M.,Kastury K.,Veronese M.L.,Rosen D.,Rothstein J.,McCue P.,Cotticelli M.G.,Inoue H.,Croce C.M.,Huebner K.

Structure and expression of the human FHIT gene in normal and tumor cells.

Cancer Res.

57

504-512

1997

671412

Corominas R.,Yang X.,Lin G.N.,Kang S.,Shen Y.,Ghamsari L.,Broly M.,Rodriguez M.,Tam S.,Wanamaker S.A.,Fan C.,Yi S.,Tasan M.,Lemmens I.,Kuang X.,Zhao N.,Malhotra D.,Michaelson J.J.,Vacic V.,Calderwood M.A.,Roth F.P.,Tavernier J.,Horvath S.,Salehi-Ashtiani K.,Korkin D.,Sebat J.,Hill D.E.,Hao T.,Vidal M.,Iakoucheva L.M.

Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

Nat. Commun.

5

3650-3650

2014

671414

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

671416

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

671417

Barnes L.D.,Garrison P.N.,Siprashvili Z.,Guranowski A.,Robinson A.K.,Ingram S.W.,Croce C.M.,Ohta M.,Huebner K.

Fhit, a putative tumor suppressor in humans, is a dinucleoside 5',5''-P1,P3-triphosphate hydrolase.

Biochemistry

35

11529-11535

1996

671418

Brenner C.,Pace H.C.,Garrison P.N.,Robinson A.K.,Rosler A.,Liu X.H.,Blackburn G.M.,Croce C.M.,Huebner K.,Barnes L.D.

Purification and crystallization of complexes modeling the active state of the fragile histidine triad protein.

Protein Eng.

10

1461-1463

1997

671419

Gemmill R.M.,West J.D.,Boldog F.,Tanaka N.,Robinson L.J.,Smith D.I.,Li F.,Drabkin H.A.

The hereditary renal cell carcinoma 3;8 translocation fuses FHIT to a patched-related gene, TRC8.

Proc. Natl. Acad. Sci. U.S.A.

95

9572-9577

1998

671420

Shi Y.,Zou M.,Farid N.R.,Paterson M.C.

Association of FHIT (fragile histidine triad), a candidate tumour suppressor gene, with the ubiquitin-conjugating enzyme hUBC9.

Biochem. J.

352

443-448

2000

671421

Trapasso F.,Krakowiak A.,Cesari R.,Arkles J.,Yendamuri S.,Ishii H.,Vecchione A.,Kuroki T.,Bieganowski P.,Pace H.C.,Huebner K.,Croce C.M.,Brenner C.

Designed FHIT alleles establish that Fhit-induced apoptosis in cancer cells is limited by substrate binding.

Proc. Natl. Acad. Sci. U.S.A.

100

1592-1597

2003

671422

Huang K.,Arabshahi A.,Wei Y.,Frey P.A.

The mechanism of action of the fragile histidine triad, Fhit: isolation of a covalent adenylyl enzyme and chemical rescue of H96G-Fhit.

Biochemistry

43

7637-7642

2004

671423

Nishizaki M.,Sasaki J.,Fang B.,Atkinson E.N.,Minna J.D.,Roth J.A.,Ji L.

Synergistic tumor suppression by coexpression of FHIT and p53 coincides with FHIT-mediated MDM2 inactivation and p53 stabilization in human non-small cell lung cancer cells.

Cancer Res.

64

5745-5752

2004

671424

Pekarsky Y.,Garrison P.N.,Palamarchuk A.,Zanesi N.,Aqeilan R.I.,Huebner K.,Barnes L.D.,Croce C.M.

Fhit is a physiological target of the protein kinase Src.

Proc. Natl. Acad. Sci. U.S.A.

101

3775-3779

2004

671425

Semba S.,Trapasso F.,Fabbri M.,McCorkell K.A.,Volinia S.,Druck T.,Iliopoulos D.,Pekarsky Y.,Ishii H.,Garrison P.N.,Barnes L.D.,Croce C.M.,Huebner K.

Fhit modulation of the Akt-survivin pathway in lung cancer cells: Fhit-tyrosine 114 (Y114) is essential.

Oncogene

25

2860-2872

2006

671426

Weiske J.,Albring K.F.,Huber O.

The tumor suppressor Fhit acts as a repressor of beta-catenin transcriptional activity.

Proc. Natl. Acad. Sci. U.S.A.

104

20344-20349

2007

671427

Guranowski A.,Wojdyla A.M.,Pietrowska-Borek M.,Bieganowski P.,Khurs E.N.,Cliff M.J.,Blackburn G.M.,Blaziak D.,Stec W.J.

Fhit proteins can also recognize substrates other than dinucleoside polyphosphates.

FEBS Lett.

582

3152-3158

2008

671428

Rimessi A.,Marchi S.,Fotino C.,Romagnoli A.,Huebner K.,Croce C.M.,Pinton P.,Rizzuto R.

Intramitochondrial calcium regulation by the FHIT gene product sensitizes to apoptosis.

Proc. Natl. Acad. Sci. U.S.A.

106

12753-12758

2009

671429

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

671430

Wojdyla-Mamon A.M.,Guranowski A.

Adenylylsulfate-ammonia adenylyltransferase activity is another inherent property of Fhit proteins.

Biosci. Rep.

35

0-0

2015

671431

Lima C.D.,D'Amico K.L.,Naday I.,Rosenbaum G.,Westbrook E.M.,Hendrickson W.A.

MAD analysis of FHIT, a putative human tumor suppressor from the HIT protein family.

Structure

5

763-774

1997

671432

Lima C.D.,Klein M.G.,Hendrickson W.A.

Structure-based analysis of catalysis and substrate definition in the HIT protein family.

Science

278

286-290

1997

671433

Pace H.C.,Garrison P.N.,Robinson A.K.,Barnes L.D.,Draganescu A.,Roesler A.,Blackburn G.M.,Siprashvili Z.,Croce C.M.,Huebner K.,Brenner C.

Genetic, biochemical, and crystallographic characterization of Fhit-substrate complexes as the active signaling form of Fhit.

Proc. Natl. Acad. Sci. U.S.A.

95

5484-5489

1998