Sequence of DPOD1_HUMAN
EC Number:2.7.7.7
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
a 2'-deoxyribonucleoside 5'-triphosphate + DNAn = diphosphate + DNAn+1
Other sequences found for EC No. 2.7.7.7
General information:
Sequence
0 MDGKRRPGPG PGVPPKRARG GLWDDDDAPR PSQFEEDLAL MEEMEAEHRL QEQEEEELQS
60 VLEGVADGQV PPSAIDPRWL RPTPPALDPQ TEPLIFQQLE IDHYVGPAQP VPGGPPPSRG
120 SVPVLRAFGV TDEGFSVCCH IHGFAPYFYT PAPPGFGPEH MGDLQRELNL AISRDSRGGR
180 ELTGPAVLAV ELCSRESMFG YHGHGPSPFL RITVALPRLV APARRLLEQG IRVAGLGTPS
240 FAPYEANVDF EIRFMVDTDI VGCNWLELPA GKYALRLKEK ATQCQLEADV LWSDVVSHPP
300 EGPWQRIAPL RVLSFDIECA GRKGIFPEPE RDPVIQICSL GLRWGEPEPF LRLALTLRPC
360 APILGAKVQS YEKEEDLLQA WSTFIRIMDP DVITGYNIQN FDLPYLISRA QTLKVQTFPF
420 LGRVAGLCSN IRDSSFQSKQ TGRRDTKVVS MVGRVQMDML QVLLREYKLR SYTLNAVSFH
480 FLGEQKEDVQ HSIITDLQNG NDQTRRRLAV YCLKDAYLPL RLLERLMVLV NAVEMARVTG
540 VPLSYLLSRG QQVKVVSQLL RQAMHEGLLM PVVKSEGGED YTGATVIEPL KGYYDVPIAT
600 LDFSSLYPSI MMAHNLCYTT LLRPGTAQKL GLTEDQFIRT PTGDEFVKTS VRKGLLPQIL
660 ENLLSARKRA KAELAKETDP LRRQVLDGRQ LALKVSANSV YGFTGAQVGK LPCLEISQSV
720 TGFGRQMIEK TKQLVESKYT VENGYSTSAK VVYGDTDSVM CRFGVSSVAE AMALGREAAD
780 WVSGHFPSPI RLEFEKVYFP YLLISKKRYA GLLFSSRPDA HDRMDCKGLE AVRRDNCPLV
840 ANLVTASLRR LLIDRDPEGA VAHAQDVISD LLCNRIDISQ LVITKELTRA ASDYAGKQAH
900 VELAERMRKR DPGSAPSLGD RVPYVIISAA KGVAAYMKSE DPLFVLEHSL PIDTQYYLEQ
960 QLAKPLLRIF EPILGEGRAE AVLLRGDHTR CKTVLTGKVG GLLAFAKRRN CCIGCRTVLS
1020 HQGAVCEFCQ PRESELYQKE VSHLNALEER FSRLWTQCQR CQGSLHEDVI CTSRDCPIFY
1080 MRKKVRKDLE DQEQLLRRFG PPGPEAW
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
664606
Chung D.W.,Zhang J.,Tan C.-K.,Davie E.W.,So A.G.,Downey K.M.
Primary structure of the catalytic subunit of human DNA polymerase delta and chromosomal location of the gene.
Proc. Natl. Acad. Sci. U.S.A.
88
11197-11201
1991
664607
Yang C.-L.,Chang L.-S.,Zhang P.,Hao H.,Zhu L.,Toomey N.L.,Lee M.Y.W.T.
Molecular cloning of the cDNA for the catalytic subunit of human DNA polymerase delta.
Nucleic Acids Res.
20
735-745
1992
664609
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
664610
Shikata K.,Ohta S.,Yamada K.,Obuse C.,Yoshikawa H.,Tsurimoto T.
The human homologue of fission Yeast cdc27, p66, is a component of active human DNA polymerase delta.
J. Biochem.
129
699-708
2001
664611
Ducoux M.,Urbach S.,Baldacci G.,Huebscher U.,Koundrioukoff S.,Christensen J.,Hughes P.
Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like PCNA-binding motif present in the third subunit of human DNA polymerase delta.
J. Biol. Chem.
276
49258-49266
2001
664612
Xie B.,Mazloum N.,Liu L.,Rahmeh A.,Li H.,Lee M.Y.
Reconstitution and characterization of the human DNA polymerase delta four-subunit holoenzyme.
Biochemistry
41
13133-13142
2002
664613
Liu L.,Rodriguez-Belmonte E.M.,Mazloum N.,Xie B.,Lee M.Y.W.T.
Identification of a novel protein, PDIP38, that interacts with the p50 subunit of DNA polymerase delta and proliferating cell nuclear antigen.
J. Biol. Chem.
278
10041-10047
2003
664614
Tsurimoto T.,Shinozaki A.,Yano M.,Seki M.,Enomoto T.
Human Werner helicase interacting protein 1 (WRNIP1) functions as a novel modulator for DNA polymerase delta.
Genes Cells
10
13-22
2005
664615
Li H.,Xie B.,Zhou Y.,Rahmeh A.,Trusa S.,Zhang S.,Gao Y.,Lee E.Y.,Lee M.Y.
Functional roles of p12, the fourth subunit of human DNA polymerase delta.
J. Biol. Chem.
281
14748-14755
2006
664616
Zhang S.,Zhou Y.,Trusa S.,Meng X.,Lee E.Y.,Lee M.Y.
A novel DNA damage response: rapid degradation of the p12 subunit of dna polymerase delta.
J. Biol. Chem.
282
15330-15340
2007
664617
Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.
A quantitative atlas of mitotic phosphorylation.
Proc. Natl. Acad. Sci. U.S.A.
105
10762-10767
2008
664618
Meng X.,Zhou Y.,Zhang S.,Lee E.Y.,Frick D.N.,Lee M.Y.
DNA damage alters DNA polymerase delta to a form that exhibits increased discrimination against modified template bases and mismatched primers.
Nucleic Acids Res.
37
647-657
2009
664619
Meng X.,Zhou Y.,Lee E.Y.,Lee M.Y.,Frick D.N.
The p12 subunit of human polymerase delta modulates the rate and fidelity of DNA synthesis.
Biochemistry
49
3545-3554
2010
664620
Ogi T.,Limsirichaikul S.,Overmeer R.M.,Volker M.,Takenaka K.,Cloney R.,Nakazawa Y.,Niimi A.,Miki Y.,Jaspers N.G.,Mullenders L.H.,Yamashita S.,Fousteri M.I.,Lehmann A.R.
Three DNA polymerases, recruited by different mechanisms, carry out NER repair synthesis in human cells.
Mol. Cell
37
714-727
2010
664621
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
664622
Chea J.,Zhang S.,Zhao H.,Zhang Z.,Lee E.Y.,Darzynkiewicz Z.,Lee M.Y.
Spatiotemporal recruitment of human DNA polymerase delta to sites of UV damage.
Cell Cycle
11
2885-2895
2012
664623
Stehling O.,Mascarenhas J.,Vashisht A.A.,Sheftel A.D.,Niggemeyer B.,Roesser R.,Pierik A.J.,Wohlschlegel J.A.,Lill R.
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins.
Cell Metab.
18
187-198
2013
664624
Stehling O.,Mascarenhas J.,Vashisht A.A.,Sheftel A.D.,Niggemeyer B.,Roesser R.,Pierik A.J.,Wohlschlegel J.A.,Lill R.
Human CIA2A-FAM96A and CIA2B-FAM96B Integrate Iron Homeostasis and Maturation of Different Subsets of Cytosolic-Nuclear Iron-Sulfur Proteins.
Cell Metab.
27
263-263
2018
664625
Lin S.H.,Wang X.,Zhang S.,Zhang Z.,Lee E.Y.,Lee M.Y.
Dynamics of enzymatic interactions during short flap human Okazaki fragment processing by two forms of human DNA polymerase delta.
DNA Repair
12
922-935
2013
664626
Zhang S.,Zhao H.,Darzynkiewicz Z.,Zhou P.,Zhang Z.,Lee E.Y.,Lee M.Y.
A novel function of CRL4(Cdt2): regulation of the subunit structure of DNA polymerase delta in response to DNA damage and during the S phase.
J. Biol. Chem.
288
29550-29561
2013
664627
Terai K.,Shibata E.,Abbas T.,Dutta A.
Degradation of p12 subunit by CRL4Cdt2 E3 ligase inhibits fork progression after DNA damage.
J. Biol. Chem.
288
30509-30514
2013
664628
Weedon M.N.,Ellard S.,Prindle M.J.,Caswell R.,Allen H.L.,Oram R.,Godbole K.,Yajnik C.S.,Sbraccia P.,Novelli G.,Turnpenny P.,McCann E.,Goh K.J.,Wang Y.,Fulford J.,McCulloch L.J.,Savage D.B.,O'Rahilly S.,Kos K.,Loeb L.A.,Semple R.K.,Hattersley A.T.
An in-frame deletion at the polymerase active site of POLD1 causes a multisystem disorder with lipodystrophy.
Nat. Genet.
45
947-950
2013
664629
Maga G.,Crespan E.,Markkanen E.,Imhof R.,Furrer A.,Villani G.,Huebscher U.,van Loon B.
DNA polymerase delta-interacting protein 2 is a processivity factor for DNA polymerase lambda during 8-oxo-7,8-dihydroguanine bypass.
Proc. Natl. Acad. Sci. U.S.A.
110
18850-18855
2013
664630
Guo A.,Gu H.,Zhou J.,Mulhern D.,Wang Y.,Lee K.A.,Yang V.,Aguiar M.,Kornhauser J.,Jia X.,Ren J.,Beausoleil S.A.,Silva J.C.,Vemulapalli V.,Bedford M.T.,Comb M.J.
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.
Mol. Cell. Proteomics
13
372-387
2014
664631
Cazzalini O.,Sommatis S.,Tillhon M.,Dutto I.,Bachi A.,Rapp A.,Nardo T.,Scovassi A.I.,Necchi D.,Cardoso M.C.,Stivala L.A.,Prosperi E.
CBP and p300 acetylate PCNA to link its degradation with nucleotide excision repair synthesis.
Nucleic Acids Res.
42
8433-8448
2014
664632
Costantino L.,Sotiriou S.K.,Rantala J.K.,Magin S.,Mladenov E.,Helleday T.,Haber J.E.,Iliakis G.,Kallioniemi O.P.,Halazonetis T.D.
Break-induced replication repair of damaged forks induces genomic duplications in human cells.
Science
343
88-91
2014
664633
Hendriks I.A.,Lyon D.,Young C.,Jensen L.J.,Vertegaal A.C.,Nielsen M.L.
Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
Nat. Struct. Mol. Biol.
24
325-336
2017
664634
Palles C.,Cazier J.B.,Howarth K.M.,Domingo E.,Jones A.M.,Broderick P.,Kemp Z.,Spain S.L.,Guarino Almeida E.,Salguero I.,Sherborne A.,Chubb D.,Carvajal-Carmona L.G.,Ma Y.,Kaur K.,Dobbins S.,Barclay E.,Gorman M.,Martin L.,Kovac M.B.,Humphray S.,Lucassen A.,Holmes C.C.,Bentley D.,Donnelly P.,Taylor J.,Petridis C.,Roylance R.,Sawyer E.J.,Kerr D.J.,Clark S.,Grimes J.,Kearsey S.E.,Thomas H.J.,McVean G.,Houlston R.S.,Tomlinson I.
Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.
Nat. Genet.
45
136-144
2013
664635
Valle L.,Hernandez-Illan E.,Bellido F.,Aiza G.,Castillejo A.,Castillejo M.I.,Navarro M.,Segui N.,Vargas G.,Guarinos C.,Juarez M.,Sanjuan X.,Iglesias S.,Alenda C.,Egoavil C.,Segura A.,Juan M.J.,Rodriguez-Soler M.,Brunet J.,Gonzalez S.,Jover R.,Lazaro C.,Capella G.,Pineda M.,Soto J.L.,Blanco I.
New insights into POLE and POLD1 germline mutations in familial colorectal cancer and polyposis.
Hum. Mol. Genet.
23
3506-3512
2014