Sequence of DMA_BPT4
EC Number:2.1.1.72
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
site-specific DNA-methyltransferase (adenine-specific)
P04392
Enterobacteria phage T4
259
30417
Reaction
S-adenosyl-L-methionine + adenine in DNA = S-adenosyl-L-homocysteine + N6-methyladenine in DNA
Other sequences found for EC No. 2.1.1.72
General information:
Sequence
0 MLGAIAYTGN KQSLLPELKS HFPKYNRFVD LFCGGLSVSL NVNGPVLAND IQEPIIEMYK
60 RLINVSWDDV LKVIKQYKLS KTSKEEFLKL REDYNKTRDP LLLYVLHFHG FSNMIRINDK
120 GNFTTPFGKR TINKNSEKQY NHFKQNCDKI IFSSLHFKDV KILDGDFVYV DPPYLITVAD
180 YNKFWSEDEE KDLLNLLDSL NDRGIKFGQS NVLEHHGKEN TLLKEWSKKY NVKHLNKKYV
240 FNIYHSKEKN GTDEVYIFN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
663555
McDonald P.M.,Mosig G.
Regulation of a new bacteriophage T4 gene, 69, that spans an origin of DNA replication.
EMBO J.
3
2863-2871
1984
663556
Miner Z.,Schlagman S.L.,Hattman S.
Single amino acid changes that alter the DNA sequence specificity of the DNA-[N6-adenine] methyltransferase (Dam) of bacteriophage T4.
Nucleic Acids Res.
17
8149-8157
1989
663557
Miller E.S.,Kutter E.,Mosig G.,Arisaka F.,Kunisawa T.,Ruger W.
Bacteriophage T4 genome.
Microbiol. Mol. Biol. Rev.
67
86-156
2003
663558
Kossykh V.G.,Schlagman S.L.,Hattman S.
Phage T4 DNA [N6-adenine]methyltransferase. Overexpression, purification, and characterization.
J. Biol. Chem.
270
14389-14393
1995
663559
Roberts R.J.,Belfort M.,Bestor T.,Bhagwat A.S.,Bickle T.A.,Bitinaite J.,Blumenthal R.M.,Degtyarev S.K.,Dryden D.T.,Dybvig K.,Firman K.,Gromova E.S.,Gumport R.I.,Halford S.E.,Hattman S.,Heitman J.,Hornby D.P.,Janulaitis A.,Jeltsch A.,Josephsen J.,Kiss A.,Klaenhammer T.R.,Kobayashi I.,Kong H.,Krueger D.H.,Lacks S.,Marinus M.G.,Miyahara M.,Morgan R.D.,Murray N.E.,Nagaraja V.,Piekarowicz A.,Pingoud A.,Raleigh E.,Rao D.N.,Reich N.,Repin V.E.,Selker E.U.,Shaw P.C.,Stein D.C.,Stoddard B.L.,Szybalski W.,Trautner T.A.,Van Etten J.L.,Vitor J.M.,Wilson G.G.,Xu S.Y.
A nomenclature for restriction enzymes, DNA methyltransferases, homing endonucleases and their genes.
Nucleic Acids Res.
31
1805-1812
2003
663560
Zinoviev V.V.,Evdokimov A.A.,Malygin E.G.,Schlagman S.L.,Hattman S.
Bacteriophage T4 Dam DNA-(N6-adenine)-methyltransferase. Processivity and orientation to the methylation target.
J. Biol. Chem.
278
7829-7833
2003
663561
Yang Z.,Horton J.R.,Zhou L.,Zhang X.J.,Dong A.,Zhang X.,Schlagman S.L.,Kossykh V.,Hattman S.,Cheng X.
Structure of the bacteriophage T4 DNA adenine methyltransferase.
Nat. Struct. Biol.
10
849-855
2003
663562
Horton J.R.,Liebert K.,Hattman S.,Jeltsch A.,Cheng X.
Transition from nonspecific to specific DNA interactions along the substrate-recognition pathway of dam methyltransferase.
Cell
121
349-361
2005
