Sequence of DMAW_CLAP2
EC Number:2.5.1.34
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
dimethylallyl diphosphate + L-tryptophan = diphosphate + 4-(3-methylbut-2-enyl)-L-tryptophan
Other sequences found for EC No. 2.5.1.34
General information:
Sequence
0 MSTAKDPGNG VYEILSLIFD FPSNEQRLWW HSTAPMFAAM LDNAGYNIHD QYRHLGIFKK
60 HIIPFLGVYP TKDKERWLSI LTRCGLPLEL SLNCTDSVVR YTYEPINEVT GTEKDPFNTL
120 AIMASVQKLA QIQAGIDLEW FSYFKDELTL DESESATLQS NELVKEQIKT QNKLALDLKE
180 SQFALKVYFY PHLKSIATGK STHDLIFDSV FKLSQKHDSI QPAFQVLCDY VSRRNHSAES
240 DQHIALHARL LSCDLIDPAK SRVKIYLLEK TVSLSVMEDL WTLGGQRVDA STMDGLDMLR
300 ELWSLLKVPT GHLEYPKGYL ELGEIPNEQL PSMANYTLHH NNPMPEPQVY FTVFGMNDAE
360 ISNALTIFFQ RHGFDDMAKK YRVFLQDSYP YHDFESLNYL HAYISFSYRR NKPYLSVYLH
420 TFETGRWPVV ADSPISFDAY RRCDLSTK
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
663517
Schardl C.L.,Young C.A.,Hesse U.,Amyotte S.G.,Andreeva K.,Calie P.J.,Fleetwood D.J.,Haws D.C.,Moore N.,Oeser B.,Panaccione D.G.,Schweri K.K.,Voisey C.R.,Farman M.L.,Jaromczyk J.W.,Roe B.A.,O'Sullivan D.M.,Scott B.,Tudzynski P.,An Z.,Arnaoudova E.G.,Bullock C.T.,Charlton N.D.,Chen L.,Cox M.,Dinkins R.D.,Florea S.,Glenn A.E.,Gordon A.,Gueldener U.,Harris D.R.,Hollin W.,Jaromczyk J.,Johnson R.D.,Khan A.K.,Leistner E.,Leuchtmann A.,Li C.,Liu J.,Liu J.,Liu M.,Mace W.,Machado C.,Nagabhyru P.,Pan J.,Schmid J.,Sugawara K.,Steiner U.,Takach J.E.,Tanaka E.,Webb J.S.,Wilson E.V.,Wiseman J.L.,Yoshida R.,Zeng Z.
Plant-symbiotic fungi as chemical engineers: Multi-genome analysis of the Clavicipitaceae reveals dynamics of alkaloid loci.
PLoS Genet.
9
0-0
2013
663519
Tudzynski P.,Hoelter K.,Correia T.H.,Arntz C.,Grammel N.,Keller U.
Evidence for an ergot alkaloid gene cluster in Claviceps purpurea.
Mol. Gen. Genet.
261
133-141
1999
663520
Tudzynski P.,Correia T.,Keller U.
Biotechnology and genetics of ergot alkaloids.
Appl. Microbiol. Biotechnol.
57
593-605
2001
663521
Correia T.,Grammel N.,Ortel I.,Keller U.,Tudzynski P.
Molecular cloning and analysis of the ergopeptine assembly system in the ergot fungus Claviceps purpurea.
Chem. Biol.
10
1281-1292
2003
663522
Wang J.,Machado C.,Panaccione D.G.,Tsai H.-F.,Schardl C.L.
The determinant step in ergot alkaloid biosynthesis by an endophyte of perennial ryegrass.
Fungal Genet. Biol.
41
189-198
2004
663523
Haarmann T.,Machado C.,Lubbe Y.,Correia T.,Schardl C.L.,Panaccione D.G.,Tudzynski P.
The ergot alkaloid gene cluster in Claviceps purpurea: extension of the cluster sequence and intra species evolution.
Phytochemistry
66
1312-1320
2005
663524
Haarmann T.,Ortel I.,Tudzynski P.,Keller U.
Identification of the cytochrome P450 monooxygenase that bridges the clavine and ergoline alkaloid pathways.
ChemBioChem
7
645-652
2006
663525
Fleetwood D.J.,Scott B.,Lane G.A.,Tanaka A.,Johnson R.D.
A complex ergovaline gene cluster in epichloe endophytes of grasses.
Appl. Environ. Microbiol.
73
2571-2579
2007
663526
Lorenz N.,Wilson E.V.,Machado C.,Schardl C.L.,Tudzynski P.
Comparison of ergot alkaloid biosynthesis gene clusters in Claviceps species indicates loss of late pathway steps in evolution of C. fusiformis.
Appl. Environ. Microbiol.
73
7185-7191
2007
663527
Haarmann T.,Lorenz N.,Tudzynski P.
Use of a nonhomologous end joining deficient strain (Deltaku70) of the ergot fungus Claviceps purpurea for identification of a nonribosomal peptide synthetase gene involved in ergotamine biosynthesis.
Fungal Genet. Biol.
45
35-44
2008
663528
Ortel I.,Keller U.
Combinatorial assembly of simple and complex D-lysergic acid alkaloid peptide classes in the ergot fungus Claviceps purpurea.
J. Biol. Chem.
284
6650-6660
2009
663529
Lorenz N.,Olsovska J.,Sulc M.,Tudzynski P.
Alkaloid cluster gene ccsA of the ergot fungus Claviceps purpurea encodes chanoclavine I synthase, a flavin adenine dinucleotide-containing oxidoreductase mediating the transformation of N-methyl-dimethylallyltryptophan to chanoclavine I.
Appl. Environ. Microbiol.
76
1822-1830
2010
663530
Cheng J.Z.,Coyle C.M.,Panaccione D.G.,O'Connor S.E.
Controlling a structural branch point in ergot alkaloid biosynthesis.
J. Am. Chem. Soc.
132
12835-12837
2010
663531
Goetz K.E.,Coyle C.M.,Cheng J.Z.,O'Connor S.E.,Panaccione D.G.
Ergot cluster-encoded catalase is required for synthesis of chanoclavine-I in Aspergillus fumigatus.
Curr. Genet.
57
201-211
2011
663532
Matuschek M.,Wallwey C.,Xie X.,Li S.M.
New insights into ergot alkaloid biosynthesis in Claviceps purpurea: an agroclavine synthase EasG catalyses, via a non-enzymatic adduct with reduced glutathione, the conversion of chanoclavine-I aldehyde to agroclavine.
Org. Biomol. Chem.
9
4328-4335
2011
663533
Havemann J.,Vogel D.,Loll B.,Keller U.
Cyclolization of D-lysergic acid alkaloid peptides.
Chem. Biol.
21
146-155
2014
