Sequence of DBR2_ARTAN
EC Number:1.3.1.92
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
(11R)-dihydroartemisinic aldehyde + NADP+ = artemisinic aldehyde + NADPH + H+
Other sequences found for EC No. 1.3.1.92
General information:
Sequence
0 MSENPPTLFS AYKMGNFNLS HRVVLAPMTR CRAINAIPNE ALVEYYRQRS TAGGFLITEG
60 TMISPSSAGF PHVPGIFTKE QVEGWKKVVD AAHKEGAVIF CQLWHVGRAS HQVYQPGGAA
120 PISSTSKPIS KKWEILLPDA TYGTYPEPRP LAANEILEVV EDYRVAAINA IEAGFDGIEI
180 HGAHGYLLDQ FMKDGINDRT DEYGGSLENR CKFILQVVQA VSAAIATDRV LIRISPAIDH
240 TDAMDSDPRS LGLAVIERLN KLQFKLGSRL AYLHVTQPRY TADGHGQTEA GANGSEEEVA
300 QLMKTWRGAY VGTFICCGGY TRELGLQAVA QGDADLVAFG RYFVSNPDLV LRLKLNAPLN
360 RYDRATFYTH DPVVGYTDYP SLDKGSLL
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
661438
Zhang Y.,Teoh K.H.,Reed D.W.,Maes L.,Goossens A.,Olson D.J.,Ross A.R.,Covello P.S.
The molecular cloning of artemisinic aldehyde Delta11(13) reductase and its role in glandular trichome-dependent biosynthesis of artemisinin in Artemisia annua.
J. Biol. Chem.
283
21501-21508
2008
661439
Ting H.-M.,Wang B.,Ryden A.-M.,Woittiez L.,van Herpen T.,Verstappen F.W.A.,Ruyter-Spira C.,Beekwilder J.,Bouwmeester H.J.,van der Krol A.
The metabolite chemotype of Nicotiana benthamiana transiently expressing artemisinin biosynthetic pathway genes is a function of CYP71AV1 type and relative gene dosage.
New Phytol.
199
352-366
2013
661440
Shen Q.,Zhang L.,Liao Z.,Wang S.,Yan T.,Shi P.,Liu M.,Fu X.,Pan Q.,Wang Y.,Lv Z.,Lu X.,Zhang F.,Jiang W.,Ma Y.,Chen M.,Hao X.,Li L.,Tang Y.,Lv G.,Zhou Y.,Sun X.,Brodelius P.E.,Rose J.K.C.,Tang K.
The genome of Artemisia annua provides insight into the evolution of Asteraceae family and artemisinin biosynthesis.
Mol. Plant
11
776-788
2018
661441
Bertea C.M.,Freije J.R.,van der Woude H.,Verstappen F.W.,Perk L.,Marquez V.,De Kraker J.W.,Posthumus M.A.,Jansen B.J.,de Groot A.,Franssen M.C.,Bouwmeester H.J.
Identification of intermediates and enzymes involved in the early steps of artemisinin biosynthesis in Artemisia annua.
Planta Med.
71
40-47
2005
661442
Olsson M.E.,Olofsson L.M.,Lindahl A.-L.,Lundgren A.,Brodelius M.,Brodelius P.E.
Localization of enzymes of artemisinin biosynthesis to the apical cells of glandular secretory trichomes of Artemisia annua L.
Phytochemistry
70
1123-1128
2009
661443
Olofsson L.,Lundgren A.,Brodelius P.E.
Trichome isolation with and without fixation using laser microdissection and pressure catapulting followed by RNA amplification: expression of genes of terpene metabolism in apical and sub-apical trichome cells of Artemisia annua L.
Plant Sci.
183
9-13
2012
661444
Tu Y.
Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture).
Angew. Chem. Int. Ed.
55
10210-10226
2016
661445
Judd R.,Bagley M.C.,Li M.,Zhu Y.,Lei C.,Yuzuak S.,Ekeloef M.,Pu G.,Zhao X.,Muddiman D.C.,Xie D.-Y.
Artemisinin biosynthesis in non-glandular trichome cells of Artemisia annua.
Mol. Plant
12
704-714
2019
661446
Liu Y.,Jing S.-X.,Luo S.-H.,Li S.-H.
Non-volatile natural products in plant glandular trichomes: chemistry, biological activities and biosynthesis.
Nat. Prod. Rep.
36
626-665
2019
661447
Uzun T.,Toptas O.
Artesunate: could be an alternative drug to chloroquine in COVID-19 treatment?
Chin. Med. J.
15
54-54
2020
661448
Cheong D.H.J.,Tan D.W.S.,Wong F.W.S.,Tran T.
Anti-malarial drug, artemisinin and its derivatives for the treatment of respiratory diseases.
Pharmacol. Res.
158
104901-104901
2020
