Sequence of CYC2_STRCO
EC Number:4.1.99.16
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
geosmin synthase
Q9X839
Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145)
726
81474
Reaction
(1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + H2O = (-)-geosmin + acetone
Other sequences found for EC No. 4.1.99.16
General information:
Sequence
0 MTQQPFQLPH FYLPHPARLN PHLDEARAHS TTWAREMGML EGSGVWEQSD LEAHDYGLLC
60 AYTHPDCDGP ALSLITDWYV WVFFFDDHFL EKYKRSQDRL AGKAHLDRLP LFMPLDDAAG
120 MPEPRNPVEA GLADLWTRTV PAMSADWRRR FAVATEHLLN ESMWELSNIN EGRVANPVEY
180 IEMRRKVGGA PWSAGLVEYA TAEVPAAVAG TRPLRVLMET FSDAVHLRND LFSYQREVED
240 EGELSNGVLV LETFFGCTTQ EAADLVNDVL TSRLHQFEHT AFTEVPAVAL EKGLTPLEVA
300 AVGAYTKGLQ DWQSGGHEWH MRSSRYMNKG ERPLAGWQAL TGPGTSAADV GALLADAVAQ
360 RARSYTYVPF QKVGPSVIPD IRMPYPLELS PALDGARRHL SEWCREMGIL SEGVWDEDKL
420 ESCDLPLCAA GLDPDATQDQ LDLASGWLAF GTYGDDYYPL VYGHRRDLAA ARLTTTRLSD
480 CMPLDGEPVP PPGNAMERSL IDLWVRTTAG MTPEERRPLK KAVDDMTEAW LWELSNQIQN
540 RVPDPVDYLE MRRATFGSDL TLGLCRAGHG PAVPPEVYRS GPVRSLENAA IDYACLLNDV
600 FSYQKEIEYE GEIHNAVLVV QNFFGVDYPA ALGVVQDLMN QRMRQFEHVV AHELPVVYDD
660 FQLSEEARTV MRGYVTDLQN WMAGILNWHR NVPRYKAEYL AGRTHGFLPD RIPAPPVPRS
720 SPALTH
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
660243
Bentley S.D.,Chater K.F.,Cerdeno-Tarraga A.-M.,Challis G.L.,Thomson N.R.,James K.D.,Harris D.E.,Quail M.A.,Kieser H.,Harper D.,Bateman A.,Brown S.,Chandra G.,Chen C.W.,Collins M.,Cronin A.,Fraser A.,Goble A.,Hidalgo J.,Hornsby T.,Howarth S.,Huang C.-H.,Kieser T.,Larke L.,Murphy L.D.,Oliver K.,O'Neil S.,Rabbinowitsch E.,Rajandream M.A.,Rutherford K.M.,Rutter S.,Seeger K.,Saunders D.,Sharp S.,Squares R.,Squares S.,Taylor K.,Warren T.,Wietzorrek A.,Woodward J.R.,Barrell B.G.,Parkhill J.,Hopwood D.A.
Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2).
Nature
417
141-147
2002
660244
Cane D.E.,Watt R.M.
Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis.
Proc. Natl. Acad. Sci. U.S.A.
100
1547-1551
2003
660245
Gust B.,Challis G.L.,Fowler K.,Kieser T.,Chater K.F.
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin.
Proc. Natl. Acad. Sci. U.S.A.
100
1541-1546
2003
660246
He X.,Cane D.E.
Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2).
J. Am. Chem. Soc.
126
2678-2679
2004
660247
Jiang J.,He X.,Cane D.E.
Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin.
J. Am. Chem. Soc.
128
8128-8129
2006
