Sequence of PIR_HUMAN
EC Number:1.13.11.24
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
quercetin + O2 = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO + H+
Other sequences found for EC No. 1.13.11.24
General information:
Sequence
0 MGSSKKVTLS VLSREQSEGV GARVRRSIGR PELKNLDPFL LFDEFKGGRP GGFPDHPHRG
60 FETVSYLLEG GSMAHEDFCG HTGKMNPGDL QWMTAGRGIL HAEMPCSEEP AHGLQLWVNL
120 RSSEKMVEPQ YQELKSEEIP KPSKDGVTVA VISGEALGIK SKVYTRTPTL YLDFKLDPGA
180 KHSQPIPKGW TSFIYTISGD VYIGPDDAQQ KIEPHHTAVL GEGDSVQVEN KDPKRSHFVL
240 IAGEPLREPV IQHGPFVMNT NEEISQAILD FRNAKNGFER AKTWKSKIGN
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
586732
Wendler W.M.F.,Kremmer E.,Foerster R.,Winnacker E.-L.
Identification of pirin, a novel highly conserved nuclear protein.
J. Biol. Chem.
272
8482-8489
1997
586735
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
586736
Dechend R.,Hirano F.,Lehmann K.,Heissmeyer V.,Ansieau S.,Wulczyn F.G.,Scheidereit C.,Leutz A.
The Bcl-3 oncoprotein acts as a bridging factor between NF-kappaB/Rel and nuclear co-regulators.
Oncogene
18
3316-3323
1999
586737
Adams M.,Jia Z.
Structural and biochemical analysis reveal pirins to possess quercetinase activity.
J. Biol. Chem.
280
28675-28682
2005
586738
Gelbman B.D.,Heguy A.,O'Connor T.P.,Zabner J.,Crystal R.G.
Upregulation of pirin expression by chronic cigarette smoking is associated with bronchial epithelial cell apoptosis.
Respir. Res.
8
10-10
2007
586739
Licciulli S.,Luise C.,Zanardi A.,Giorgetti L.,Viale G.,Lanfrancone L.,Carbone R.,Alcalay M.
Pirin delocalization in melanoma progression identified by high content immuno-detection based approaches.
BMC Cell Biol.
11
5-5
2010
586740
Tang N.L.,Liao C.D.,Ching J.K.,Suen E.W.,Chan I.H.,Orwoll E.,Ho S.C.,Chan F.W.,Kwok A.W.,Kwok T.,Woo J.,Leung P.C.
Sex-specific effect of Pirin gene on bone mineral density in a cohort of 4000 Chinese.
Bone
46
543-550
2010
586741
Licciulli S.,Cambiaghi V.,Scafetta G.,Gruszka A.M.,Alcalay M.
Pirin downregulation is a feature of AML and leads to impairment of terminal myeloid differentiation.
Leukemia
24
429-437
2010
586742
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
586743
Van Damme P.,Lasa M.,Polevoda B.,Gazquez C.,Elosegui-Artola A.,Kim D.S.,De Juan-Pardo E.,Demeyer K.,Hole K.,Larrea E.,Timmerman E.,Prieto J.,Arnesen T.,Sherman F.,Gevaert K.,Aldabe R.
N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
Proc. Natl. Acad. Sci. U.S.A.
109
12449-12454
2012
586744
Pang H.,Bartlam M.,Zeng Q.,Miyatake H.,Hisano T.,Miki K.,Wong L.L.,Gao G.F.,Rao Z.
Crystal structure of human pirin: an iron-binding nuclear protein and transcription cofactor.
J. Biol. Chem.
279
1491-1498
2004
586745
Miyazaki I.,Simizu S.,Okumura H.,Takagi S.,Osada H.
A small-molecule inhibitor shows that pirin regulates migration of melanoma cells.
Nat. Chem. Biol.
6
667-673
2010
586746
Liu F.,Rehmani I.,Esaki S.,Fu R.,Chen L.,de Serrano V.,Liu A.
Pirin is an iron-dependent redox regulator of NF-kappaB.
Proc. Natl. Acad. Sci. U.S.A.
110
9722-9727
2013
