Sequence of PHF8_HUMAN

[histone H3]-dimethyl-L-lysine36 demethylase

Q9UPP1

1060

117864

585831

Kikuno R.,Nagase T.,Ishikawa K.,Hirosawa M.,Miyajima N.,Tanaka A.,Kotani H.,Nomura N.,Ohara O.

Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

DNA Res.

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1999

585832

Nakajima D.,Okazaki N.,Yamakawa H.,Kikuno R.,Ohara O.,Nagase T.

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

DNA Res.

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2002

585833

Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.

Complete sequencing and characterization of 21,243 full-length human cDNAs.

Nat. Genet.

36

40-45

2004

585834

Bechtel S.,Rosenfelder H.,Duda A.,Schmidt C.P.,Ernst U.,Wellenreuther R.,Mehrle A.,Schuster C.,Bahr A.,Bloecker H.,Heubner D.,Hoerlein A.,Michel G.,Wedler H.,Koehrer K.,Ottenwaelder B.,Poustka A.,Wiemann S.,Schupp I.

The full-ORF clone resource of the German cDNA consortium.

BMC Genomics

8

399-399

2007

585835

Ross M.T.,Grafham D.V.,Coffey A.J.,Scherer S.,McLay K.,Muzny D.,Platzer M.,Howell G.R.,Burrows C.,Bird C.P.,Frankish A.,Lovell F.L.,Howe K.L.,Ashurst J.L.,Fulton R.S.,Sudbrak R.,Wen G.,Jones M.C.,Hurles M.E.,Andrews T.D.,Scott C.E.,Searle S.,Ramser J.,Whittaker A.,Deadman R.,Carter N.P.,Hunt S.E.,Chen R.,Cree A.,Gunaratne P.,Havlak P.,Hodgson A.,Metzker M.L.,Richards S.,Scott G.,Steffen D.,Sodergren E.,Wheeler D.A.,Worley K.C.,Ainscough R.,Ambrose K.D.,Ansari-Lari M.A.,Aradhya S.,Ashwell R.I.,Babbage A.K.,Bagguley C.L.,Ballabio A.,Banerjee R.,Barker G.E.,Barlow K.F.,Barrett I.P.,Bates K.N.,Beare D.M.,Beasley H.,Beasley O.,Beck A.,Bethel G.,Blechschmidt K.,Brady N.,Bray-Allen S.,Bridgeman A.M.,Brown A.J.,Brown M.J.,Bonnin D.,Bruford E.A.,Buhay C.,Burch P.,Burford D.,Burgess J.,Burrill W.,Burton J.,Bye J.M.,Carder C.,Carrel L.,Chako J.,Chapman J.C.,Chavez D.,Chen E.,Chen G.,Chen Y.,Chen Z.,Chinault C.,Ciccodicola A.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Clerc-Blankenburg K.,Clifford K.,Cobley V.,Cole C.G.,Conquer J.S.,Corby N.,Connor R.E.,David R.,Davies J.,Davis C.,Davis J.,Delgado O.,Deshazo D.,Dhami P.,Ding Y.,Dinh H.,Dodsworth S.,Draper H.,Dugan-Rocha S.,Dunham A.,Dunn M.,Durbin K.J.,Dutta I.,Eades T.,Ellwood M.,Emery-Cohen A.,Errington H.,Evans K.L.,Faulkner L.,Francis F.,Frankland J.,Fraser A.E.,Galgoczy P.,Gilbert J.,Gill R.,Gloeckner G.,Gregory S.G.,Gribble S.,Griffiths C.,Grocock R.,Gu Y.,Gwilliam R.,Hamilton C.,Hart E.A.,Hawes A.,Heath P.D.,Heitmann K.,Hennig S.,Hernandez J.,Hinzmann B.,Ho S.,Hoffs M.,Howden P.J.,Huckle E.J.,Hume J.,Hunt P.J.,Hunt A.R.,Isherwood J.,Jacob L.,Johnson D.,Jones S.,de Jong P.J.,Joseph S.S.,Keenan S.,Kelly S.,Kershaw J.K.,Khan Z.,Kioschis P.,Klages S.,Knights A.J.,Kosiura A.,Kovar-Smith C.,Laird G.K.,Langford C.,Lawlor S.,Leversha M.,Lewis L.,Liu W.,Lloyd C.,Lloyd D.M.,Loulseged H.,Loveland J.E.,Lovell J.D.,Lozado R.,Lu J.,Lyne R.,Ma J.,Maheshwari M.,Matthews L.H.,McDowall J.,McLaren S.,McMurray A.,Meidl P.,Meitinger T.,Milne S.,Miner G.,Mistry S.L.,Morgan M.,Morris S.,Mueller I.,Mullikin J.C.,Nguyen N.,Nordsiek G.,Nyakatura G.,O'dell C.N.,Okwuonu G.,Palmer S.,Pandian R.,Parker D.,Parrish J.,Pasternak S.,Patel D.,Pearce A.V.,Pearson D.M.,Pelan S.E.,Perez L.,Porter K.M.,Ramsey Y.,Reichwald K.,Rhodes S.,Ridler K.A.,Schlessinger D.,Schueler M.G.,Sehra H.K.,Shaw-Smith C.,Shen H.,Sheridan E.M.,Shownkeen R.,Skuce C.D.,Smith M.L.,Sotheran E.C.,Steingruber H.E.,Steward C.A.,Storey R.,Swann R.M.,Swarbreck D.,Tabor P.E.,Taudien S.,Taylor T.,Teague B.,Thomas K.,Thorpe A.,Timms K.,Tracey A.,Trevanion S.,Tromans A.C.,d'Urso M.,Verduzco D.,Villasana D.,Waldron L.,Wall M.,Wang Q.,Warren J.,Warry G.L.,Wei X.,West A.,Whitehead S.L.,Whiteley M.N.,Wilkinson J.E.,Willey D.L.,Williams G.,Williams L.,Williamson A.,Williamson H.,Wilming L.,Woodmansey R.L.,Wray P.W.,Yen J.,Zhang J.,Zhou J.,Zoghbi H.,Zorilla S.,Buck D.,Reinhardt R.,Poustka A.,Rosenthal A.,Lehrach H.,Meindl A.,Minx P.J.,Hillier L.W.,Willard H.F.,Wilson R.K.,Waterston R.H.,Rice C.M.,Vaudin M.,Coulson A.,Nelson D.L.,Weinstock G.,Sulston J.E.,Durbin R.M.,Hubbard T.,Gibbs R.A.,Beck S.,Rogers J.,Bentley D.R.

The DNA sequence of the human X chromosome.

Nature

434

325-337

2005

585836

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

585837

Laumonnier F.,Holbert S.,Ronce N.,Faravelli F.,Lenzner S.,Schwartz C.E.,Lespinasse J.,Van Esch H.,Lacombe D.,Goizet C.,Phan-Dinh Tuy F.,van Bokhoven H.,Fryns J.-P.,Chelly J.,Ropers H.-H.,Moraine C.,Hamel B.C.J.,Briault S.

Mutations in PHF8 are associated with X linked mental retardation and cleft lip/cleft palate.

J. Med. Genet.

42

780-786

2005

585838

Olsen J.V.,Blagoev B.,Gnad F.,Macek B.,Kumar C.,Mortensen P.,Mann M.

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

Cell

127

635-648

2006

585839

Dephoure N.,Zhou C.,Villen J.,Beausoleil S.A.,Bakalarski C.E.,Elledge S.J.,Gygi S.P.

A quantitative atlas of mitotic phosphorylation.

Proc. Natl. Acad. Sci. U.S.A.

105

10762-10767

2008

585840

Gauci S.,Helbig A.O.,Slijper M.,Krijgsveld J.,Heck A.J.,Mohammed S.

Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

Anal. Chem.

81

4493-4501

2009

585841

Mayya V.,Lundgren D.H.,Hwang S.-I.,Rezaul K.,Wu L.,Eng J.K.,Rodionov V.,Han D.K.

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

Sci. Signal.

2

0-0

2009

585842

Zhu Z.,Wang Y.,Li X.,Wang Y.,Xu L.,Wang X.,Sun T.,Dong X.,Chen L.,Mao H.,Yu Y.,Li J.,Chen P.A.,Chen C.D.

PHF8 is a histone H3K9me2 demethylase regulating rRNA synthesis.

Cell Res.

20

794-801

2010

585843

Qiu J.,Shi G.,Jia Y.,Li J.,Wu M.,Li J.,Dong S.,Wong J.

The X-linked mental retardation gene PHF8 is a histone demethylase involved in neuronal differentiation.

Cell Res.

20

908-918

2010

585844

Loenarz C.,Ge W.,Coleman M.L.,Rose N.R.,Cooper C.D.O.,Klose R.J.,Ratcliffe P.J.,Schofield C.J.

PHF8, a gene associated with cleft lip/palate and mental retardation, encodes for an Nepsilon-dimethyl lysine demethylase.

Hum. Mol. Genet.

19

217-222

2010

585845

Kleine-Kohlbrecher D.,Christensen J.,Vandamme J.,Abarrategui I.,Bak M.,Tommerup N.,Shi X.,Gozani O.,Rappsilber J.,Salcini A.E.,Helin K.

A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation.

Mol. Cell

38

165-178

2010

585846

Fortschegger K.,de Graaf P.,Outchkourov N.S.,van Schaik F.M.,Timmers H.T.,Shiekhattar R.

PHF8 targets histone methylation and RNA polymerase II to activate transcription.

Mol. Cell. Biol.

30

3286-3298

2010

585847

Feng W.,Yonezawa M.,Ye J.,Jenuwein T.,Grummt I.

PHF8 activates transcription of rRNA genes through H3K4me3 binding and H3K9me1/2 demethylation.

Nat. Struct. Mol. Biol.

17

445-450

2010

585848

Qi H.H.,Sarkissian M.,Hu G.Q.,Wang Z.,Bhattacharjee A.,Gordon D.B.,Gonzales M.,Lan F.,Ongusaha P.P.,Huarte M.,Yaghi N.K.,Lim H.,Garcia B.A.,Brizuela L.,Zhao K.,Roberts T.M.,Shi Y.

Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development.

Nature

466

503-507

2010

585849

Liu W.,Tanasa B.,Tyurina O.V.,Zhou T.Y.,Gassmann R.,Liu W.T.,Ohgi K.A.,Benner C.,Garcia-Bassets I.,Aggarwal A.K.,Desai A.,Dorrestein P.C.,Glass C.K.,Rosenfeld M.G.

PHF8 mediates histone H4 lysine 20 demethylation events involved in cell cycle progression.

Nature

466

508-512

2010

585850

Olsen J.V.,Vermeulen M.,Santamaria A.,Kumar C.,Miller M.L.,Jensen L.J.,Gnad F.,Cox J.,Jensen T.S.,Nigg E.A.,Brunak S.,Mann M.

Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

Sci. Signal.

3

0-0

2010

585851

Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.

Initial characterization of the human central proteome.

BMC Syst. Biol.

5

17-17

2011

585852

Rigbolt K.T.,Prokhorova T.A.,Akimov V.,Henningsen J.,Johansen P.T.,Kratchmarova I.,Kassem M.,Mann M.,Olsen J.V.,Blagoev B.

System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

Sci. Signal.

4

0-0

2011

585853

Zhou H.,Di Palma S.,Preisinger C.,Peng M.,Polat A.N.,Heck A.J.,Mohammed S.

Toward a comprehensive characterization of a human cancer cell phosphoproteome.

J. Proteome Res.

12

260-271

2013

585854

Yu Z.,Feng J.,Wang W.,Deng Z.,Zhang Y.,Xiao L.,Wang Z.,Liu C.,Liu Q.,Chen S.,Wu M.

The EGFR-ZNF263 signaling axis silences SIX3 in glioblastoma epigenetically.

Oncogene

39

3163-3178

2020

585855

Yu L.,Wang Y.,Huang S.,Wang J.,Deng Z.,Zhang Q.,Wu W.,Zhang X.,Liu Z.,Gong W.,Chen Z.

Structural insights into a novel histone demethylase PHF8.

Cell Res.

20

166-173

2010

585856

Yue W.W.,Hozjan V.,Ge W.,Loenarz C.,Cooper C.D.,Schofield C.J.,Kavanagh K.L.,Oppermann U.,McDonough M.A.

Crystal structure of the PHF8 Jumonji domain, an N(epsilon)-methyl lysine demethylase.

FEBS Lett.

584

825-830

2010

585857

Horton J.R.,Upadhyay A.K.,Qi H.H.,Zhang X.,Shi Y.,Cheng X.

Enzymatic and structural insights for substrate specificity of a family of jumonji histone lysine demethylases.

Nat. Struct. Mol. Biol.

17

38-43

2010

585858

Koivisto A.M.,Ala-Mello S.,Lemmelae S.,Komu H.A.,Rautio J.,Jaervelae I.

Screening of mutations in the PHF8 gene and identification of a novel mutation in a Finnish family with XLMR and cleft lip/cleft palate.

Clin. Genet.

72

145-149

2007

585859

Nava C.,Lamari F.,Heron D.,Mignot C.,Rastetter A.,Keren B.,Cohen D.,Faudet A.,Bouteiller D.,Gilleron M.,Jacquette A.,Whalen S.,Afenjar A.,Perisse D.,Laurent C.,Dupuits C.,Gautier C.,Gerard M.,Huguet G.,Caillet S.,Leheup B.,Leboyer M.,Gillberg C.,Delorme R.,Bourgeron T.,Brice A.,Depienne C.

Analysis of the chromosome X exome in patients with autism spectrum disorders identified novel candidate genes, including TMLHE.

Transl. Psychiatry

2

0-0

2012