Sequence of B8MM59_TALSN
EC Number:2.3.1.161
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
lovastatin nonaketide synthase
B8MM59
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)
2528
277252
Reaction
9 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O
Other sequences found for EC No. 2.3.1.161
General information:
Sequence
0 MGDSGSSKPS EWTQVNGSHT SDEMISNEAG SVEPIAIVGV SCRLPGGASS PSKLWDLLEA
60 GKSAWGPFPS NRFSHSGFHS PFGLKNGTTN TNGGHFLEDD IAAFDAAFFG IRPMEATAID
120 PQQRLLLEVA YEAFENAGIT SEQVWGSNTG VYVGQWTSDY NEVLSRDTNF PAFYQTTGTG
180 PAISSNRLSY YFNMKGPSFT VDTGCSASMV ALHSAVQSLR TGETDRSFVA GVNLTLDPQR
240 YTYQSQLKMF SKEGKSFPFD ERANGYGRGE GCTGVVLQTL SSALKEGKPI RAIIRNSVLN
300 QDGRTPGISV PSGLAQSAAI RKAYAQAGIN LLDVDYVEAH GTGTKVGDPI EAKAIADALS
360 SSRDEENPLL IGSVKGNVGH LESAAGLTGL LKGLLMLEKC LVPPQVNFER ANTTIPLKQL
420 KLRVSTYDEQ LPLRDLRRIS INCFGYGGTN AHVILDSVDS FFAPPSPLTG RIKAPSKPEK
480 SARSRIFILS AETEKSVQVS AQKMAEYLKS KSGYTVNADI WLNNLAYTLG RRSLFGHRAG
540 VVASAVDELI VQLEDLSQQA VPRRDTKGQR RIGFVFSGQG AQYAGMGKEL LGNFPAFSNS
600 LERAGKCLTD IGCSWDLISE LLKPAEETRV DEPEVAQPLS TAIQLALADT LAELGIFPSF
660 VAGHSSGEIA AAYCAKAISF DDAMTVSYHR GRLASTLRKR VSDHPGGMLA VGESPEVVAA
720 KIKEIGEAQT RLRIACFNSP SSVTVSGDDD AILLLQEVLS GADIFNRKLR TGGAAYHSHQ
780 MDLIESEYRK ALDGIKGGKT DVSIVMVSSL TGEDIGDTVI DKDYWVQNLV SPVKFTEATR
840 KLCQTWSGQK RLDLLLELGP HFQLGGPISQ TLRTLRGDSA KIPYTGTLKR GTNAETTIFS
900 ALRTLFLEGF PVKLDLVNNG FDSTTANKLV TDVPSYSFDH SRTFWHESRI SKAYRYRKNI
960 PHDLLGTMGG DYNSVEPRWR KFIRLDDLPW LRGHIVQGQV VFPAAGYLAM AIQAMKEQIL
1020 DENPDASIKN YKLRNVSFGM ALVLSEGIEN LELNFSLRPQ VHSARKSSKT WNEFRVFTVT
1080 ADNSWTEHCR GLVHVELASE GDMNRVISAQ DQDLHAQLLQ FGKYINPKKL YFLAKDLGLD
1140 WVSPFDNVID VKTTNGAAIS TVKPSDQDAT PYLIHPAVLD ACLFHSLYAV LIFEDNFKET
1200 VVPTFIKTLN VAGNLGDLST KNLTCFARRT TGQLTYDIGI FDKEVEPATV FLQASTVTAT
1260 RLPGLVPVEE GSRDLIHSIE WVTYMQSLTK NQIKRFKEGL EKVDSVMDRN NRLDALAMSY
1320 IQQALKEVSP EEVGEGHLKH WYAWMRTHAY DSFDTTVLAE AMMDETIGGQ ALRRLGPHLP
1380 DILRGNAHPL SFMREDGLLE KVYLEERCIR CYDQIAAYCA EFGRQAPDMK ILEIGAGTAS
1440 VTLPLLEKIK SDDRVLASRY DFTDISAGFF PAAKERLAEY ENVVNYQVLN AENDPVEQGF
1500 SANSYDIVVA CNVIHATSNI ETVLKNVRSL LRPGGKFILM EITLNQLYYN MFYGAFSGWW
1560 SGYDEGRTMS PLLSIPQWKD KLYKTGFEQT EPMFNDYERK DGGTISVFVA HANETHKSEA
1620 VNSAVDIVGL SPDDNVAGRL SKTLKELLSN QDILPTNLQA LGQSDTVSIF LPEVCDLLAG
1680 SLDEEQWKSL KERITTSRAA LFITQARLSE STRPDGTVIN GFLRSLRMEH HEIRLISLEI
1740 SAEGTVDSVA DVIAEVLCSP SFDLDAVAGD VESEYRERDG QLYVPRVIAQ REMSKFVHSS
1800 LGKSQPTGSS FLGHNRVLTA ELAIPGLLET VRWRDDPEAI GPLDPDHIKI RLGAASINFK
1860 DVLIASGQLE GINQMQNDCS GTVVEVGANM RNRYKPGDRV CALYSRSYTN YPIVHGDCCH
1920 LIPDTLSIEE AASLPIVWIT VYYSIIDMGK LKKGESVLIH SGAGAVGQAA IMLAKYLGAK
1980 IFVTVGSDAK KEFLMEKFGI PEDHFFSSRN TSFYEEIMQI TGGHGVDVVL NSLSGEMFRE
2040 STNVVAPFGR FVEIGRKDLM DDALMPMEFL LKNVTFSYVD MALVIAKAKT LAQRVLHDVI
2100 ELIIAGAISP VSIMTMPISK LEDAFRLIQA GKHIGKVILT VSEDQRVKII PPRPELAKLK
2160 QDATYIVVGG LGGLGKQIVK WMAERGAKNI VTFSRSGTLN EQTLALIDSV KELGTTVYVK
2220 KCDVGDMDQL RRVMAELKDN LPPIRGIVQS AMILEDSVFD EMTFKHWLDA VNPKVEGTWN
2280 LHKALPSNLD FFIMLSSAVA VAGNVGQSNY SAACAFQDAL AHYRTSRGLR AHSINVGAIV
2340 EIGYVSENPE VAASLRRQGM GTTSVYEFLA HLDQVISNPI ACQPGHCQTS IGLVPSGDEL
2400 GLGESVWMED MKFTHVRRQG SSQIQISGAT SDVITELRSV GTPEDAVEVI CQAILIQLSK
2460 VTALPAERLS RGESLDTYGV DSLVAVELRN WIGAYLQANV PLLVLRGTGS IQELAEMSPK
2520 SPGSWRIP
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
8637203
Nierman W.C.,Fedorova-Abrams N.D.,Andrianopoulos A.
Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).
Genome Announc.
3
0-0
2015
