Sequence of B8MJ47_TALSN
EC Number:2.3.1.161
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
lovastatin nonaketide synthase
B8MJ47
Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006)
2574
283293
Reaction
9 malonyl-CoA + 11 NADPH + 10 H+ + S-adenosyl-L-methionine + holo-[lovastatin nonaketide synthase] = dihydromonacolin L-[lovastatin nonaketide synthase] + 9 CoA + 9 CO2 + 11 NADP+ + S-adenosyl-L-homocysteine + 6 H2O
Other sequences found for EC No. 2.3.1.161
General information:
Sequence
0 MTSLLSDSLS NSLEPSPQTL WELMATGKCV ASQFPSDRIS ATRYHVVDDS RPGTIRPQKA
60 CFLERDISAF DAKLFGMTPD EAAGTDPQQR IILETTYRAL ENAGIPMQKA NGSDTSVHTG
120 CFTADYTLAS AKDLENAPRY AGTGMAASML SNRISTFFNL RGPSMTIDTA CSSSLVALDM
180 ACQDLRHQRT SMGIVAGCNL LLGPDFFITL SSLGFVSPDG VSHAFDNRAN GYGRGEGFGV
240 LILKTVEDAI KDGDTIRAII RVTKTNQNGR TSLAQPSKEM QASLIQETYR DAELKTSLTR
300 FFEAHGTGTA IGDPLEAMAI GSTFGPGRDS DDPVIVGAVK ANIGHLEGAA GIAGIIKTIL
360 VLERGLIPPI AELQDLNDKI DAEFLKLKFP RALTPWPREG LRRASINSFG FGGTNAHVVL
420 DDALHYLKGR GLVANHCTNA TPLEHKVIEQ KHLPKPDMET KALATMKGPR LFVWSGHEKS
480 SVTQMVELYR VYLKKLQSQN IDGLDTYHDM LAYTLAQRRS LHNWRSFAVA DSVCQLVERL
540 VTPRLPSQSR TNPKSGFVFT GQGAQWAGMG KELIVFPAFR NSILAADKFL ASIGSVWKPS
600 DFFFDDDEIR ARINEPRFSQ ILCTILQIAL VELLRTFHIH PTVVAGHSSG EIAAAYAVGG
660 ISRQSAWKIA YFRGLFCSAL AESSGTTPHG AMMAVGLSES SVQPYIDEIL QDSPGRGVLV
720 AACMNSPKNT TVSGDKCLIE QLQAKLLADA IFARVLKVPV AYHSPHMHRI AAPYREVIGK
780 LDRGETPPVF ATMVSSVTGD IIPISELVKS EYWVRNLVSP VQFSAALGRI FQDSAKKVQK
840 KFDLSHRSVA SVSDLIEIGP HSAMEGPIRE IKEATASPAK DGISYTATLD RGRAATETIL
900 EAAGKLHCVG FDVNLGNVNA PFLERDPFDH AHTYWHESRI SKNIRLNPQP YNAFLGLPVP
960 DWNPLEPRWR NIVRLSSMPW LEDHKVNGEI LFPAAGMMVM AMEAIKQIST EQTITGFEFR
1020 EIGILNALMI SQDDEGVEVL FHLKPSFDSI SKTNSWATFS LYAYRGENFI EVSRGSIKAL
1080 SASQIQSDME HAQNSHVHEL LSSAKSSCLT ETSSADLYAD LEKNGYQYGP AFQGIESARR
1140 DNCGQALGRV STNKFLHADT SLDANIPDIH PCTLDSILQV CIPAVAWGNN NRTATWVPTF
1200 IKKGWLARSG FKASEQNDML YVQSSTTSRG TRLAEADLNV VDTSGSNLLG QAEGIEITLV
1260 ADEDQVHGGN SSSTVRRLCW DMIYKPDPTL LGTEQLSQYA IESLKPETGP TELIQALKLY
1320 ILASISRAIN EVAGSDIPTH HMHLQKQYAW SQTMIDTANR QPPSDISYTW HDYIEDTQYN
1380 NLCDHVKEIG GRLGDIYVHF GSHLTDMLRG RVDALQVLVP DNRLKDYYEL SNNLGQFFNP
1440 MQRYVDAMAH KNPGMKILEV GAGTGATTRF MLDTLASRTP NGVYSRFSRY DFTDVTGSFI
1500 ESAENEFGSI PKMNFGLFDV EEDPVGQGYE EGSYDLIVAA NVVHATKCLR KTLSNIRKLL
1560 RDDGKLILIE ITATTTYPLT QYLFGFLPGW WLSTEPWRQD GPCVTLERWS EELEASGFNK
1620 YHLALHDFEV EDNQVTSLLI SSVKPPVNNS TGKYAAVIDK TALVITGWEE PSLESFLSEL
1680 VKSRMEEMGM RSVRPSSFRE VGGLVDLEDK LVLIVQDRAW LSLEHLDPRE YYLFNTTLAR
1740 ARNILWVSEA SPPTAAHVSP IGPVTGIARA LRSEKQNILF GTVTLCTSSS PTVLSLNVER
1800 AVQNFLQGTS SQTYERELVQ VGDYLCIPRI YENGELNQKV HDFTFASFKP QQRFGEQNLK
1860 LRVRRPGLLD SVYFEEVPEA GPLGSDEIEV EVKAIGVNFR DCLIALGRID QDILGTECAG
1920 LVRRVGSACQ LRPGDRVMVG DVDTYHGVIR CKEILAVKMP EDMSLVDAAS VPTNFVTVYH
1980 AFVRVSNLPP GESVLIHSGA GGTGQAAIQV AQYCGAEIYT TVGSSSKKRL LMEMYGIPED
2040 HIFNSRDLSF VAEIKRSTQN RGVDVVLNSL AGDALVASWE CIAPFGRFIE IGKKDIFSHN
2100 KLPMFQFARN VSFSAIDLAS MAQERPDLIQ SGLLGITNLF RRKILRMPSP MKSFPISDVE
2160 GAFRYLQSGM NPGKVVLEID QEAIVPAMVK TRSDWNFSPE ETFILGGGLG AQGQMISEWM
2220 VSKGARYLVL LSRRGINNNA VLESFVSKLQ STGAVVYCPK CDVSDPESLA AVVKYCRTNM
2280 PPIKGCIQAA MELRDSVFEN IDHAAWSACL RPKVDGSWNL HEQLPRDLDF FILFSSIAGV
2340 VGSQGQANYA AGNTFQDELA KYRLSRGEKA ISLNLSMIAD HGYALEHEEA ARRFAKSRFV
2400 LEMTQPEVLA MLEHYCDKRL QLDPAHSQIA NGLELPEDIS NRGMDIMGWM HEPIFTILHQ
2460 MGSSVGMANN SIDSKDKGPS LIKQLEEAPS IAEAADVVAN GIAAKLCKAL SISPDSFDIS
2520 QPLHIYGVDS LIAVEMRNWF MQVLRADVAV FEILGGATAS TLGRAVAEKV RAVV
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
8629548
Nierman W.C.,Fedorova-Abrams N.D.,Andrianopoulos A.
Genome sequence of the AIDS-associated pathogen Penicillium marneffei (ATCC18224) and its near taxonomic relative Talaromyces stipitatus (ATCC10500).
Genome Announc.
3
0-0
2015
