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Sequence of MMP3_HUMAN

EC Number:3.4.24.17

EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
stromelysin 1
P08254
Homo sapiens
477
53977
Reaction
preferential cleavage where P1', P2' and P3' are hydrophobic residues
Other sequences found for EC No. 3.4.24.17

General information:

Sequence
show sequence in fasta format
  0 MKSLPILLLL CVAVCSAYPL DGAARGEDTS MNLVQKYLEN YYDLKKDVKQ FVRRKDSGPV
 60 VKKIREMQKF LGLEVTGKLD SDTLEVMRKP RCGVPDVGHF RTFPGIPKWR KTHLTYRIVN
120 YTPDLPKDAV DSAVEKALKV WEEVTPLTFS RLYEGEADIM ISFAVREHGD FYPFDGPGNV
180 LAHAYAPGPG INGDAHFDDD EQWTKDTTGT NLFLVAAHEI GHSLGLFHSA NTEALMYPLY
240 HSLTDLTRFR LSQDDINGIQ SLYGPPPDSP ETPLVPTEPV PPEPGTPANC DPALSFDAVS
300 TLRGEILIFK DRHFWRKSLR KLEPELHLIS SFWPSLPSGV DAAYEVTSKD LVFIFKGNQF
360 WAIRGNEVRA GYPRGIHTLG FPPTVRKIDA AISDKEKNKT YFFVEDKYWR FDEKRNSMEP
420 GFPKQIAEDF PGIDSKIDAV FEEFGFFYFF TGSSQLEFDP NAKKVTHTLK SNSWLNC
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Sequence related references
Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
570637
Saus J.,Quinones S.,Otani Y.,Nagase H.,Harris E.D. Jr.,Kurkinen M.
The complete primary structure of human matrix metalloproteinase-3. Identity with stromelysin.
J. Biol. Chem.
263
6742-6745
1988
570638
Whitham S.E.,Murphy G.,Angel P.,Rahmsdorf H.J.,Smith B.,Lyons A.,Harris T.J.R.,Reynolds J.J.,Herrlich P.,Docherty A.J.P.
Comparison of human stromelysin and collagenase by cloning and sequence analysis.
Biochem. J.
240
913-916
1986
570639
Wilhelm S.M.,Collier I.E.,Kronberger A.,Eisen A.Z.,Marmer B.L.,Grant G.A.,Bauer E.A.,Goldberg G.I.
Human skin fibroblast stromelysin: structure, glycosylation, substrate specificity, and differential expression in normal and tumorigenic cells.
Proc. Natl. Acad. Sci. U.S.A.
84
6725-6729
1987
570641
Ota T.,Suzuki Y.,Nishikawa T.,Otsuki T.,Sugiyama T.,Irie R.,Wakamatsu A.,Hayashi K.,Sato H.,Nagai K.,Kimura K.,Makita H.,Sekine M.,Obayashi M.,Nishi T.,Shibahara T.,Tanaka T.,Ishii S.,Yamamoto J.,Saito K.,Kawai Y.,Isono Y.,Nakamura Y.,Nagahari K.,Murakami K.,Yasuda T.,Iwayanagi T.,Wagatsuma M.,Shiratori A.,Sudo H.,Hosoiri T.,Kaku Y.,Kodaira H.,Kondo H.,Sugawara M.,Takahashi M.,Kanda K.,Yokoi T.,Furuya T.,Kikkawa E.,Omura Y.,Abe K.,Kamihara K.,Katsuta N.,Sato K.,Tanikawa M.,Yamazaki M.,Ninomiya K.,Ishibashi T.,Yamashita H.,Murakawa K.,Fujimori K.,Tanai H.,Kimata M.,Watanabe M.,Hiraoka S.,Chiba Y.,Ishida S.,Ono Y.,Takiguchi S.,Watanabe S.,Yosida M.,Hotuta T.,Kusano J.,Kanehori K.,Takahashi-Fujii A.,Hara H.,Tanase T.-O.,Nomura Y.,Togiya S.,Komai F.,Hara R.,Takeuchi K.,Arita M.,Imose N.,Musashino K.,Yuuki H.,Oshima A.,Sasaki N.,Aotsuka S.,Yoshikawa Y.,Matsunawa H.,Ichihara T.,Shiohata N.,Sano S.,Moriya S.,Momiyama H.,Satoh N.,Takami S.,Terashima Y.,Suzuki O.,Nakagawa S.,Senoh A.,Mizoguchi H.,Goto Y.,Shimizu F.,Wakebe H.,Hishigaki H.,Watanabe T.,Sugiyama A.,Takemoto M.,Kawakami B.,Yamazaki M.,Watanabe K.,Kumagai A.,Itakura S.,Fukuzumi Y.,Fujimori Y.,Komiyama M.,Tashiro H.,Tanigami A.,Fujiwara T.,Ono T.,Yamada K.,Fujii Y.,Ozaki K.,Hirao M.,Ohmori Y.,Kawabata A.,Hikiji T.,Kobatake N.,Inagaki H.,Ikema Y.,Okamoto S.,Okitani R.,Kawakami T.,Noguchi S.,Itoh T.,Shigeta K.,Senba T.,Matsumura K.,Nakajima Y.,Mizuno T.,Morinaga M.,Sasaki M.,Togashi T.,Oyama M.,Hata H.,Watanabe M.,Komatsu T.,Mizushima-Sugano J.,Satoh T.,Shirai Y.,Takahashi Y.,Nakagawa K.,Okumura K.,Nagase T.,Nomura N.,Kikuchi H.,Masuho Y.,Yamashita R.,Nakai K.,Yada T.,Nakamura Y.,Ohara O.,Isogai T.,Sugano S.
Complete sequencing and characterization of 21,243 full-length human cDNAs.
Nat. Genet.
36
40-45
2004
570645
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
570646
Nagase H.,Enghild J.J.,Suzuki K.,Salvesen G.
Stepwise activation mechanisms of the precursor of matrix metalloproteinase 3 (stromelysin) by proteinases and (4-aminophenyl)mercuric acetate.
Biochemistry
29
5783-5789
1990
570647
Ye S.,Eriksson P.,Hamsten A.,Kurkinen M.,Humphries S.E.,Henney A.M.
Progression of coronary atherosclerosis is associated with a common genetic variant of the human stromelysin-1 promoter which results in reduced gene expression.
J. Biol. Chem.
271
13055-13060
1996
570648
Yamada Y.,Izawa H.,Ichihara S.,Takatsu F.,Ishihara H.,Hirayama H.,Sone T.,Tanaka M.,Yokota M.
Prediction of the risk of myocardial infarction from polymorphisms in candidate genes.
N. Engl. J. Med.
347
1916-1923
2002
570649
Gooley P.R.,O'Connell J.F.,Marcy A.I.,Cuca G.C.,Salowe S.P.,Bush B.L.,Hermes J.D.,Esser C.K.,Hagmann W.K.,Springer J.P.,Johnson B.A.
The NMR structure of the inhibited catalytic domain of human stromelysin-1.
Nat. Struct. Biol.
1
111-118
1994
570650
Stockman B.J.,Waldon D.J.,Gates J.A.,Scahill T.A.,Kloosterman D.A.,Mizsak S.A.,Jacobsen E.J.,Belonga K.L.,Mitchell M.A.,Mao B.,Petke J.D.,Goodman L.,Powers E.A.,Ledbetter S.R.,Kaytes P.S.,Vogeli G.,Marshall V.P.,Petzold G.L.,Poorman R.A.
Solution structures of stromelysin complexed to thiadiazole inhibitors.
Protein Sci.
7
2281-2286
1998
570651
Becker J.W.,Marcy A.I.,Rokosz L.L.,Axel M.G.,Burbaum J.J.,Fitzgerald P.M.D.,Cameron P.M.,Esser C.K.,Hagmann W.K.,Hermes J.D.,Springer J.P.
Stromelysin-1: three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme.
Protein Sci.
4
1966-1976
1995
570652
Dhanaraj V.,Ye Q.-Z.,Johnson L.L.,Hupe D.J.,Otwine D.F.,Dunbar J.B. Jr.,Rubin J.R.,Pavlovsky A.,Humblet C.,Blundell T.L.
X-ray structure of a hydroxamate inhibitor complex of stromelysin catalytic domain and its comparison with members of the zinc metalloproteinase superfamily.
Structure
4
375-386
1996
570653
Esser C.K.,Bugianesi R.L.,Caldwell C.G.,Chapman K.T.,Durette P.L.,Girotra N.N.,Kopka I.E.,Lanza T.J.,Levorse D.A.,Maccoss M.,Owens K.A.,Ponpipom M.M.,Simeone J.P.,Harrison R.K.,Niedzwiecki L.,Becker J.W.,Marcy A.I.,Axel M.G.,Christen A.J.,McDonnell J.,Moore V.L.,Olszewski J.M.,Saphos C.,Visco D.M.,Shen F.,Colletti A.,Kriter P.A.,Hagmann W.K.
Inhibition of stromelysin-1 (MMP-3) by P1'-biphenylylethyl carboxyalkyl dipeptides.
J. Med. Chem.
40
1026-1040
1997
570654
Gomis-Rueth F.-X.,Maskos K.,Betz M.,Bergner A.,Huber R.,Suzuki K.,Yoshida N.,Nagase H.,Brew K.,Bourenkov G.P.,Bartunik H.,Bode W.
Mechanism of inhibition of the human matrix metalloproteinase stromelysin-1 by TIMP-1.
Nature
389
77-81
1997
570655
Finzel B.C.,Baldwin E.T.,Bryant G.L. Jr.,Hess G.F.,Wilks J.W.,Trepod C.M.,Mott J.E.,Marshall V.P.,Petzold G.L.,Poorman R.A.,O'Sullivan T.J.,Schostarez H.J.,Mitchell M.A.
Structural characterizations of nonpeptidic thiadiazole inhibitors of matrix metalloproteinases reveal the basis for stromelysin selectivity.
Protein Sci.
7
2118-2126
1998
570656
Chen L.,Rydel T.J.,Gu F.,Dunaway C.M.,Pikul S.,Dunham K.M.,Barnett B.L.
Crystal structure of the stromelysin catalytic domain at 2.0-A resolution: inhibitor-induced conformational changes.
J. Mol. Biol.
293
545-557
1999
570657
Pavlovsky A.G.,Williams M.G.,Ye Q.-Z.,Ortwine D.F.,Purchase C.F. II,White A.D.,Dhanaraj V.,Roth B.D.,Johnson L.L.,Hupe D.,Humblet C.,Blundell T.L.
X-ray structure of human stromelysin catalytic domain complexed with nonpeptide inhibitors: implications for inhibitor selectivity.
Protein Sci.
8
1455-1462
1999
570658
Li Y.C.,Zhang X.,Melton R.,Ganu V.,Gonnella N.C.
Solution structure of the catalytic domain of human stromelysin-1 complexed to a potent, nonpeptidic inhibitor.
Biochemistry
37
14048-14056
1998