Sequence of KATG_MYCTU
EC Number:1.11.1.21
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
2 H2O2 = O2 + 2 H2O
Other sequences found for EC No. 1.11.1.21
General information:
Sequence
0 MPEQHPPITE TTTGAASNGC PVVGHMKYPV EGGGNQDWWP NRLNLKVLHQ NPAVADPMGA
60 AFDYAAEVAT IDVDALTRDI EEVMTTSQPW WPADYGHYGP LFIRMAWHAA GTYRIHDGRG
120 GAGGGMQRFA PLNSWPDNAS LDKARRLLWP VKKKYGKKLS WADLIVFAGN CALESMGFKT
180 FGFGFGRVDQ WEPDEVYWGK EATWLGDERY SGKRDLENPL AAVQMGLIYV NPEGPNGNPD
240 PMAAAVDIRE TFRRMAMNDV ETAALIVGGH TFGKTHGAGP ADLVGPEPEA APLEQMGLGW
300 KSSYGTGTGK DAITSGIEVV WTNTPTKWDN SFLEILYGYE WELTKSPAGA WQYTAKDGAG
360 AGTIPDPFGG PGRSPTMLAT DLSLRVDPIY ERITRRWLEH PEELADEFAK AWYKLIHRDM
420 GPVARYLGPL VPKQTLLWQD PVPAVSHDLV GEAEIASLKS QIRASGLTVS QLVSTAWAAA
480 SSFRGSDKRG GANGGRIRLQ PQVGWEVNDP DGDLRKVIRT LEEIQESFNS AAPGNIKVSF
540 ADLVVLGGCA AIEKAAKAAG HNITVPFTPG RTDASQEQTD VESFAVLEPK ADGFRNYLGK
600 GNPLPAEYML LDKANLLTLS APEMTVLVGG LRVLGANYKR LPLGVFTEAS ESLTNDFFVN
660 LLDMGITWEP SPADDGTYQG KDGSGKVKWT GSRVDLVFGS NSELRALVEV YGADDAQPKF
720 VQDFVAAWDK VMNLDRFDVR
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
50259
Heym B.,Zhang Y.,Poulet S.,Young D.,Cole S.T.
Characterization of the katG gene encoding a catalase-peroxidase required for the isoniazid susceptibility of Mycobacterium tuberculosis.
J. Bacteriol.
175
4255-4259
1993
50261
Cockerill F.R. III,Uhl J.R.,Temesgen Z.,Zhang Y.,Stockman L.,Roberts G.D.,Williams D.L.,Kline B.C.
Rapid identification of a point mutation of the Mycobacterium tuberculosis catalase-peroxidase (katG) gene associated with isoniazid resistance.
J. Infect. Dis.
171
240-245
1995
50263
Daum L.T.,Rodriguez J.D.,Worthy S.A.,Ismail N.A.,Omar S.V.,Dreyer A.W.,Fourie P.B.,Hoosen A.A.,Chambers J.P.,Fischer G.W.
Next-generation ion torrent sequencing of drug resistance mutations in Mycobacterium tuberculosis strains.
J. Clin. Microbiol.
50
3831-3837
2012
50264
Cole S.T.,Brosch R.,Parkhill J.,Garnier T.,Churcher C.M.,Harris D.E.,Gordon S.V.,Eiglmeier K.,Gas S.,Barry C.E. III,Tekaia F.,Badcock K.,Basham D.,Brown D.,Chillingworth T.,Connor R.,Davies R.M.,Devlin K.,Feltwell T.,Gentles S.,Hamlin N.,Holroyd S.,Hornsby T.,Jagels K.,Krogh A.,McLean J.,Moule S.,Murphy L.D.,Oliver S.,Osborne J.,Quail M.A.,Rajandream M.A.,Rogers J.,Rutter S.,Seeger K.,Skelton S.,Squares S.,Squares R.,Sulston J.E.,Taylor K.,Whitehead S.,Barrell B.G.
Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.
Nature
393
537-544
1998
50265
Zhang Y.,Heym B.,Allen B.,Young D.,Cole S.T.
The catalase-peroxidase gene and isoniazid resistance of Mycobacterium tuberculosis.
Nature
358
591-593
1992
50267
Mulder M.A.,Nair S.,Abratt V.R.,Zappe H.,Steyn L.M.
Involvement of the N- and C-terminal domains of Mycobacterium tuberculosis KatG in the protection of mutant Escherichia coli against DNA-damaging agents.
Microbiology
145
2011-2021
1999
50268
Sherman D.R.,Mdluli K.,Hickey M.J.,Arain T.M.,Morris S.L.,Barry C.E. III,Stover C.K.
Compensatory ahpC gene expression in isoniazid-resistant Mycobacterium tuberculosis.
Science
272
1641-1643
1996
50269
Johnsson K.,Froland W.A.,Schultz P.G.
Overexpression, purification, and characterization of the catalase-peroxidase KatG from Mycobacterium tuberculosis.
J. Biol. Chem.
272
2834-2840
1997
50270
Wengenack N.L.,Jensen M.P.,Rusnak F.,Stern M.K.
Mycobacterium tuberculosis KatG is a peroxynitritase.
Biochem. Biophys. Res. Commun.
256
485-487
1999
50271
Pym A.S.,Domenech P.,Honore N.,Song J.,Deretic V.,Cole S.T.
Regulation of catalase-peroxidase (KatG) expression, isoniazid sensitivity and virulence by furA of Mycobacterium tuberculosis.
Mol. Microbiol.
40
879-889
2001
50272
Ng V.H.,Cox J.S.,Sousa A.O.,MacMicking J.D.,McKinney J.D.
Role of KatG catalase-peroxidase in mycobacterial pathogenesis: countering the phagocyte oxidative burst.
Mol. Microbiol.
52
1291-1302
2004
50273
Ghiladi R.A.,Knudsen G.M.,Medzihradszky K.F.,Ortiz de Montellano P.R.
The Met-Tyr-Trp cross-link in Mycobacterium tuberculosis catalase-peroxidase (KatG): autocatalytic formation and effect on enzyme catalysis and spectroscopic properties.
J. Biol. Chem.
280
22651-22663
2005
50274
Jakopitsch C.,Vlasits J.,Wiseman B.,Loewen P.C.,Obinger C.
Redox intermediates in the catalase cycle of catalase-peroxidases from Synechocystis PCC 6803, Burkholderia pseudomallei, and Mycobacterium tuberculosis.
Biochemistry
46
1183-1193
2007
50275
Singh R.,Switala J.,Loewen P.C.,Ivancich A.
Two [Fe(IV)=O Trp*] intermediates in M.tuberculosis catalase-peroxidase discriminated by multifrequency (9-285 GHz) EPR spectroscopy: reactivity toward isoniazid.
J. Am. Chem. Soc.
129
15954-15963
2007
50276
Singh R.,Wiseman B.,Deemagarn T.,Jha V.,Switala J.,Loewen P.C.
Comparative study of catalase-peroxidases (KatGs).
Arch. Biochem. Biophys.
471
207-214
2008
50277
Raman K.,Yeturu K.,Chandra N.
targetTB: a target identification pipeline for Mycobacterium tuberculosis through an interactome, reactome and genome-scale structural analysis.
BMC Syst. Biol.
2
109-109
2008
50278
Kelkar D.S.,Kumar D.,Kumar P.,Balakrishnan L.,Muthusamy B.,Yadav A.K.,Shrivastava P.,Marimuthu A.,Anand S.,Sundaram H.,Kingsbury R.,Harsha H.C.,Nair B.,Prasad T.S.,Chauhan D.S.,Katoch K.,Katoch V.M.,Kumar P.,Chaerkady R.,Ramachandran S.,Dash D.,Pandey A.
Proteogenomic analysis of Mycobacterium tuberculosis by high resolution mass spectrometry.
Mol. Cell. Proteomics
10
0-0
2011
50279
Ando H.,Kitao T.,Miyoshi-Akiyama T.,Kato S.,Mori T.,Kirikae T.
Downregulation of katG expression is associated with isoniazid resistance in Mycobacterium tuberculosis.
Mol. Microbiol.
79
1615-1628
2011
50280
Bertrand T.,Eady N.A.J.,Jones J.N.,Jesmin X.,Nagy J.M.,Jamart-Gregoire B.,Raven E.L.,Brown K.A.
Crystal structure of Mycobacterium tuberculosis catalase-peroxidase.
J. Biol. Chem.
279
38991-38999
2004
50281
Zhao X.,Yu H.,Yu S.,Wang F.,Sacchettini J.C.,Magliozzo R.S.
Hydrogen peroxide-mediated isoniazid activation catalyzed by Mycobacterium tuberculosis catalase-peroxidase (KatG) and its S315T mutant.
Biochemistry
45
4131-4140
2006
50282
Zhao X.,Hersleth H.P.,Zhu J.,Andersson K.K.,Magliozzo R.S.
Access channel residues Ser315 and Asp137 in Mycobacterium tuberculosis catalase-peroxidase (KatG) control peroxidatic activation of the pro-drug isoniazid.
Chem. Commun. (Camb.)
49
11650-11652
2013
