Sequence of ISG20_HUMAN
EC Number:3.1.13.1
EC Number
Recommended Name
Accession Code
Organism
No of amino acids
Molecular Weight [Da]
Source
Reaction
Exonucleolytic cleavage in the 3'- to 5'- direction to yield nucleoside 5'-phosphates
Other sequences found for EC No. 3.1.13.1
General information:
Sequence
0 MAGSREVVAM DCEMVGLGPH RESGLARCSL VNVHGAVLYD KFIRPEGEIT DYRTRVSGVT
60 PQHMVGATPF AVARLEILQL LKGKLVVGHD LKHDFQALKE DMSGYTIYDT STDRLLWREA
120 KLDHCRRVSL RVLSERLLHK SIQNSLLGHS SVEDARATME LYQISQRIRA RRGLPRLAVS
180 D
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Sequence Reference
Authors
Title
Journal
Volume
Pages
Year
PubMed ID
48786
Gongora C.,David G.,Pintard L.,Tissot C.,Hua T.D.,Dejean A.,Mechti N.
Molecular cloning of a new interferon-induced PML nuclear bodies-associated protein.
J. Biol. Chem.
272
19457-19463
1997
48787
Pentecost B.T.
Expression and estrogen regulation of the HEM45 mRNA in human tumor lines and in the rat uterus.
J. Steroid Biochem. Mol. Biol.
64
25-33
1998
48790
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Genome Res.
14
2121-2127
2004
48791
Nguyen L.H.,Espert L.,Mechti N.,Wilson D.M. III
The human interferon- and estrogen-regulated ISG20/HEM45 gene product degrades single-stranded RNA and DNA in vitro.
Biochemistry
40
7174-7179
2001
48792
Espert L.,Degols G.,Gongora C.,Blondel D.,Williams B.R.,Silverman R.H.,Mechti N.
ISG20, a new interferon-induced RNase specific for single-stranded RNA, defines an alternative antiviral pathway against RNA genomic viruses.
J. Biol. Chem.
278
16151-16158
2003
48793
Espert L.,Degols G.,Lin Y.L.,Vincent T.,Benkirane M.,Mechti N.
Interferon-induced exonuclease ISG20 exhibits an antiviral activity against human immunodeficiency virus type 1.
J. Gen. Virol.
86
2221-2229
2005
48794
Espert L.,Eldin P.,Gongora C.,Bayard B.,Harper F.,Chelbi-Alix M.K.,Bertrand E.,Degols G.,Mechti N.
The exonuclease ISG20 mainly localizes in the nucleolus and the Cajal (Coiled) bodies and is associated with nuclear SMN protein-containing complexes.
J. Cell. Biochem.
98
1320-1333
2006
48795
Degols G.,Eldin P.,Mechti N.
ISG20, an actor of the innate immune response.
Biochimie
89
831-835
2007
48796
Burkard T.R.,Planyavsky M.,Kaupe I.,Breitwieser F.P.,Buerckstuemmer T.,Bennett K.L.,Superti-Furga G.,Colinge J.
Initial characterization of the human central proteome.
BMC Syst. Biol.
5
17-17
2011
48797
Zhou Z.,Wang N.,Woodson S.E.,Dong Q.,Wang J.,Liang Y.,Rijnbrand R.,Wei L.,Nichols J.E.,Guo J.T.,Holbrook M.R.,Lemon S.M.,Li K.
Antiviral activities of ISG20 in positive-strand RNA virus infections.
Virology
409
175-188
2011
48798
Horio T.,Murai M.,Inoue T.,Hamasaki T.,Tanaka T.,Ohgi T.
Crystal structure of human ISG20, an interferon-induced antiviral ribonuclease.
FEBS Lett.
577
111-116
2004
