Sequence of AK1C4_HUMAN

3alpha-hydroxysteroid 3-dehydrogenase

P17516

323

37067

512937

Qin K.-N.,New M.I.,Cheng K.-C.

Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase.

J. Steroid Biochem. Mol. Biol.

46

673-679

1993

512938

Khanna M.,Qin K.-N.,Wang R.W.,Cheng K.-C.

Substrate specificity, gene structure, and tissue-specific distribution of multiple human 3 alpha-hydroxysteroid dehydrogenases.

J. Biol. Chem.

270

20162-20168

1995

512939

Khanna M.,Qin K.-N.,Cheng K.-C.

Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans.

J. Steroid Biochem. Mol. Biol.

53

41-46

1995

512940

Kume T.,Iwasa H.,Shiraishi H.,Yokoi T.,Nagashima K.,Otsuka M.,Terada T.,Takagi T.,Hara A.,Kamataki T.

Characterization of a novel variant (S145C/L311V) of 3alpha-hydroxysteroid/dihydrodiol dehydrogenase in human liver.

Pharmacogenetics

9

763-771

1999

512941

Nishizawa M.,Nakajima T.,Yasuda K.,Kanzaki H.,Sasaguri Y.,Watanabe K.,Ito S.

Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes.

Genes Cells

5

111-125

2000

512942

Dufort I.,Labrie F.,Luu-The V.

Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution.

J. Clin. Endocrinol. Metab.

86

841-846

2001

512943

Deloukas P.,Earthrowl M.E.,Grafham D.V.,Rubenfield M.,French L.,Steward C.A.,Sims S.K.,Jones M.C.,Searle S.,Scott C.,Howe K.,Hunt S.E.,Andrews T.D.,Gilbert J.G.R.,Swarbreck D.,Ashurst J.L.,Taylor A.,Battles J.,Bird C.P.,Ainscough R.,Almeida J.P.,Ashwell R.I.S.,Ambrose K.D.,Babbage A.K.,Bagguley C.L.,Bailey J.,Banerjee R.,Bates K.,Beasley H.,Bray-Allen S.,Brown A.J.,Brown J.Y.,Burford D.C.,Burrill W.,Burton J.,Cahill P.,Camire D.,Carter N.P.,Chapman J.C.,Clark S.Y.,Clarke G.,Clee C.M.,Clegg S.,Corby N.,Coulson A.,Dhami P.,Dutta I.,Dunn M.,Faulkner L.,Frankish A.,Frankland J.A.,Garner P.,Garnett J.,Gribble S.,Griffiths C.,Grocock R.,Gustafson E.,Hammond S.,Harley J.L.,Hart E.,Heath P.D.,Ho T.P.,Hopkins B.,Horne J.,Howden P.J.,Huckle E.,Hynds C.,Johnson C.,Johnson D.,Kana A.,Kay M.,Kimberley A.M.,Kershaw J.K.,Kokkinaki M.,Laird G.K.,Lawlor S.,Lee H.M.,Leongamornlert D.A.,Laird G.,Lloyd C.,Lloyd D.M.,Loveland J.,Lovell J.,McLaren S.,McLay K.E.,McMurray A.,Mashreghi-Mohammadi M.,Matthews L.,Milne S.,Nickerson T.,Nguyen M.,Overton-Larty E.,Palmer S.A.,Pearce A.V.,Peck A.I.,Pelan S.,Phillimore B.,Porter K.,Rice C.M.,Rogosin A.,Ross M.T.,Sarafidou T.,Sehra H.K.,Shownkeen R.,Skuce C.D.,Smith M.,Standring L.,Sycamore N.,Tester J.,Thorpe A.,Torcasso W.,Tracey A.,Tromans A.,Tsolas J.,Wall M.,Walsh J.,Wang H.,Weinstock K.,West A.P.,Willey D.L.,Whitehead S.L.,Wilming L.,Wray P.W.,Young L.,Chen Y.,Lovering R.C.,Moschonas N.K.,Siebert R.,Fechtel K.,Bentley D.,Durbin R.M.,Hubbard T.,Doucette-Stamm L.,Beck S.,Smith D.R.,Rogers J.

The DNA sequence and comparative analysis of human chromosome 10.

Nature

429

375-381

2004

512944

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

Genome Res.

14

2121-2127

2004

512945

Winters C.J.,Molowa D.T.,Guzelian P.S.

Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase.

Biochemistry

29

1080-1087

1990

512946

Deyashiki Y.,Ogasawara A.,Nakayama T.,Nakanishi M.,Miyabe Y.,Sato K.,Hara A.

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.

Biochem. J.

299

545-552

1994

512947

Binstock J.M.,Iyer R.B.,Hamby C.V.,Fried V.A.,Schwartz I.S.,Weinstein B.I.,Southren A.L.

Human hepatic 3 alpha-hydroxysteroid dehydrogenase: possible identity with human hepatic chlordecone reductase.

Biochem. Biophys. Res. Commun.

187

760-766

1992

512948

Molowa D.T.,Shayne A.G.,Guzelian P.S.

Purification and characterization of chlordecone reductase from human liver.

J. Biol. Chem.

261

12624-12627

1986

512949

Penning T.M.,Burczynski M.E.,Jez J.M.,Hung C.F.,Lin H.K.,Ma H.,Moore M.,Palackal N.,Ratnam K.

Human 3alpha-hydroxysteroid dehydrogenase isoforms (AKR1C1-AKR1C4) of the aldo-keto reductase superfamily: functional plasticity and tissue distribution reveals roles in the inactivation and formation of male and female sex hormones.

Biochem. J.

351

67-77

2000

512950

Steckelbroeck S.,Jin Y.,Gopishetty S.,Oyesanmi B.,Penning T.M.

Human cytosolic 3alpha-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3beta-hydroxysteroid dehydrogenase activity: implications for steroid hormone metabolism and action.

J. Biol. Chem.

279

10784-10795

2004

512951

Jin Y.,Duan L.,Lee S.H.,Kloosterboer H.J.,Blair I.A.,Penning T.M.

Human cytosolic hydroxysteroid dehydrogenases of the aldo-ketoreductase superfamily catalyze reduction of conjugated steroids: implications for phase I and phase II steroid hormone metabolism.

J. Biol. Chem.

284

10013-10022

2009

512952

Fluck C.E.,Meyer-Boni M.,Pandey A.V.,Kempna P.,Miller W.L.,Schoenle E.J.,Biason-Lauber A.

Why boys will be boys: two pathways of fetal testicular androgen biosynthesis are needed for male sexual differentiation.

Am. J. Hum. Genet.

89

201-218

2011

512953

Bian Y.,Song C.,Cheng K.,Dong M.,Wang F.,Huang J.,Sun D.,Wang L.,Ye M.,Zou H.

An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

J. Proteomics

96

253-262

2014