EC Number   |
Protein Variants |
Reference |
|---|
    4.2.3.146 | F107A |
mutation results in the formation of a monocyclic cembrene, which structurally bears no resemblance to the parent compound cyclooctat-9-en-7-ol |
-, 747560 |
| 4.2.3.146 | F107A |
site-directed mutagenesis, the mutant follows a different reaction mechanism compared to wild-type and produces the different product cembrane A in addition to cyclooctat-9-en-7-ol |
-, 746593, 746744 |
| 4.2.3.146 | F107G |
the mutant enzyme produces cembrene A as single cyclization product |
-, 747560 |
| 4.2.3.146 | F107L |
site-directed mutagenesis, the mutant follows a different reaction mechanism compared to wild-type and produces the different products 3,7-dolabellatriene-9-ol and cyclooctat-6-en-8-ol in addition to cyclooctat-9-en-7-ol |
-, 746593 |
| 4.2.3.146 | F107Y |
site-directed mutagenesis, the mutant follows a different reaction mechanism compared to wild-type and produces the different product cyclooctat-1,7-diene |
-, 746593, 746744 |
| 4.2.3.146 | F107Y |
the mutant enzyme produces a product mixture |
-, 747560 |
| 4.2.3.146 | F149H |
the mutant enzyme produces a single cyclization product |
747560 |
| 4.2.3.146 | F149L |
cyclisation of geranylgeranyl diphosphate by the the mutant enzyme results in the formation of the non-natural fusicoccane macrocycle cyclooctat-7-en-3-ol |
-, 747560 |
| 4.2.3.146 | F149L |
site-directed mutagenesis, the mutant follows a different reaction mechanism compared to wild-type and produces the different product cyclooctat-7-en-3-ol, no formation of cyclooctat-9-en-7-ol |
-, 746593, 746744 |
| 4.2.3.146 | F149V |
the mutant enzyme produces a single cyclization product |
-, 747560 |
