EC Number   |
Protein Variants |
Reference |
|---|
   3.5.1.B15 | A143T |
site-directed mutagenesis, the mutation decreases the Km and kcat values of the enzyme |
758283 |
| 3.5.1.B15 | A143T/T168A/E173K |
site-directed mutagenesis, the mutation decreases the Km and kcat values of the enzyme, the mutant shows reduced thermostability compared to wild-type |
758283 |
| 3.5.1.B15 | A146V |
naturally occuring mutation, the mutant shows 72% reduced activity compared to wild-type, resistant strain |
757008 |
| 3.5.1.B15 | C138Y |
site-directed mutagenesis |
757448 |
| 3.5.1.B15 | D126N |
site-directed mutagenesis, the mutation causes pyrazinamide resistance, the mutation is located outside of active site and has an allosteric affect |
-, 757305 |
| 3.5.1.B15 | D12A |
site-directed mutagenesis |
-, 757448 |
| 3.5.1.B15 | D12A |
site-directed mutagenesis, the mutation highly reduces the mutant activity compared to wild-type |
-, 756516 |
| 3.5.1.B15 | D12G |
site-directed mutagenesis |
-, 757448 |
| 3.5.1.B15 | D12G |
site-directed mutagenesis, the mutation highly reduces the mutant activity compared to wild-type |
-, 756516 |
| 3.5.1.B15 | D136G |
site-directed mutagenesis, the mutation highly reduces the mutant activity compared to wild-type |
756516 |
