EC Number   |
Protein Variants |
Reference |
|---|
   3.5.1.98 | C261S |
the single mutant forms about 70% less covalent adduct with 5-deoxy-DELTA12,14-prostaglandin J2-biotin compared to the wild type enzyme |
712434 |
| 3.5.1.98 | C261S/C273S |
the double mutant shows about 95% less alkylation by 0.005 mM 5-deoxy-DELTA12,14-prostaglandin J2-biotin compared to the wild type enzyme |
712434 |
| 3.5.1.98 | C273S |
the single mutant forms about 70% less covalent adduct with 5-deoxy-DELTA12,14-prostaglandin J2-biotin compared to the wild type enzyme |
712434 |
| 3.5.1.98 | D101A |
mutant, confirms that the strictly conserved side chain of D101 is crucial for the function of the L2 loop |
696240 |
| 3.5.1.98 | D101E |
mutant, confirms that the strictly conserved side chain of D101 is crucial for the function of the L2 loop |
696240 |
| 3.5.1.98 | D101L |
mutant, confirms that the strictly conserved side chain of D101 is crucial for the function of the L2 loop |
696240 |
| 3.5.1.98 | D101N |
mutant, confirms that the strictly conserved side chain of D101 is crucial for the function of the L2 loop |
696240 |
| 3.5.1.98 | D174N |
isoform HDAC1 mutant, about 5% of wild-type activity, reduced ability to bind a trapoxin-affinity matrix and decreased interaction with proteins RbAp48 and mSin3A |
682594 |
| 3.5.1.98 | D174N/D176N |
isoform HDAC1 mutant, about 3% of wild-type activity, reduced ability to bind a trapoxin-affinity matrix and decreased interaction with proteins RbAp48 and mSin3A |
682594 |
| 3.5.1.98 | D176A |
the mutation increases the K1/2 for potassium inhibition by more than 40fold |
712485 |
