EC Number   |
Protein Variants |
Reference |
|---|
   3.4.22.47 | C476A |
high Kgp activity and black pigmentation |
677861 |
| 3.4.22.47 | C476A/C477A |
no Kgp activity nor black pigmentation |
677861 |
| 3.4.22.47 | C477A |
no Kgp activity nor black pigmentation |
677861 |
| 3.4.22.47 | more |
complement killing resistancy of Porphyromonas gingivalis is examined using Arg- and Lys-gingipain (K1A) deletion mutants and polysaccharide synthesis deletion mutants. Arg- and Lys-gingipain (K1A) deletion mutants maintained resistance to killing |
680131 |
| 3.4.22.47 | more |
construction of a strain producing Kgp proteinase without the adhesin domains in a Rgp/Kgp/adhesin-null mutant, mutant strains 33277, KDP133, and KDP160 phenotypes, overview |
-, 699480 |
| 3.4.22.47 | more |
construction of enzyme-deficient mutants KDP136 with DELTArgpADELTArgpBDELTAkgp, and KDP129 with DELTArgpADELTArgpB. The mutants do not, in contrast to the wild-type enzyme, inhibit cellular proliferation and don not arrest the cell cycle in the G0/G1 phase as well as decrease the expression levels of the cell-cycle regulatory molecules cyclin D and cyclin E in murine ST2 cells, overview |
-, 700531 |
| 3.4.22.47 | more |
construction of kgp-deficient mutant strains WS1, WS10, and WS15, and of Kgp and HmuR double mutants, which show reduced hemoglobin degradation and utilization due to abolished enzyme activity, Arg-specific gingipain R, EC 3.4.22.37, can compensate partially for the mutation, overview |
667031 |
| 3.4.22.47 | more |
construction of several C-terminally truncated enzyme mutant strains, which show decreased activity compared to the wild-type strain as well as altered distribution of the enzyme between membrane-associated and secreted forms, overview |
670309 |
| 3.4.22.47 | more |
gingipain-deficient Porphyromonas gingivalis mutants lacking both Arg- and Lys-gingipains are unable to induce interleukin-1beta, interleukin-6, and interleukin-8 degradation |
700534 |
| 3.4.22.47 | more |
in the gene PG0027, encoding protein PG27, deletion mutant 83K10, the activities of Arg-gingipain and Lys-gingipain are severely reduced, while the activities of secreted exopeptidases DPPIV, DPP-7, and PTP-A are unaffected |
-, 697990 |
