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Protein Variants:
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EC Number
Protein Variants
Commentary
Reference
3.4.21.46
S94Y
6fold increase in turnover number
36587
3.4.21.46
R115C
activity like wild type
718398
3.4.21.46
P43S
can not induce cell survival
698902
3.4.21.46
R22I
can not induce cell survival
698902
3.4.21.46
R22L
can not induce cell survival
698902
3.4.21.46
G51C
can not induce cell survival, has increased dimer to monomer ratio
698902
3.4.21.46
H133A
catalytically inactive
718398
3.4.21.46
R157A
catalytically inactive
718398
3.4.21.46
S183A
catalytically inactive
718398
3.4.21.46
C53A
does not bind the soluble receptors VEGFR-2/IgGFc and VEGFR-3/IgGFc
698902
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