EC Number   |
Protein Variants |
Reference |
|---|
   3.4.19.12 | C132A |
site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme |
710436 |
| 3.4.19.12 | C132S |
no effect on protein insolubility or interactions |
680081 |
| 3.4.19.12 | C14A |
mutant of ataxin-3 carrying six consecutive glutamines, does not undergo proteolytic fragmentation on incubation at room temperature |
679751 |
| 3.4.19.12 | C14A/H119L |
mutant of ataxin-3 carrying six consecutive glutamines, does not undergo proteolytic fragmentation on incubation at room temperature |
679751 |
| 3.4.19.12 | C152A |
site-directed mutagenesis, removal of the C152 thiol group by mutation renders the protein refractory to attack by 15-deoxy-DELTA12,14-prostaglandin J2 |
710436 |
| 3.4.19.12 | C152S |
binds to monoubiquitin in both 4-hydroxy-2-nonenal-treated cells and untreated cells |
680081 |
| 3.4.19.12 | C201A |
site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme |
710436 |
| 3.4.19.12 | C209S |
catalytically inactive, does not suppress NF-kappaB nuclear translocation and transcriptional activity by targeting the TNFR signaling pathway at the level of the IkappaB kinase complex or upstream from it. Does not suppress polyubiquitinated RIP1 and does not enhance the levels of monubiquinated or unmodified RIP1 as compared to the wild-type |
698869 |
| 3.4.19.12 | C220A |
site-directed mutagenesis, the mutant behaves similar to the wild-type enzyme |
710436 |
| 3.4.19.12 | C220S |
no effect on protein insolubility or interactions |
680081 |
