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Protein Variants:
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EC Number
Protein Variants
Commentary
Reference
3.2.1.78
C143A
the mutant shows reduced activity compared to the wild type enzyme
749657
3.2.1.78
D283A
increase of Km-value by about 80%
656020
3.2.1.78
D283H
dramatic decrease of Km-value
656020
3.2.1.78
E167A
about 60% loss of catalytic efficiency
699537
3.2.1.78
E212A
dramatic decrease of Km-value
656020
3.2.1.78
E222A
no catalytic acitivity
677739
3.2.1.78
E266A
complete loss of activity
699537
3.2.1.78
E91A
no catalytic acitivity
677739
3.2.1.78
H143A
decrease of Km-value by about 50%
656020
3.2.1.78
H1A/H23A
about 10% loss of catalytic efficiency
699537
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