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Protein Variants:
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EC Number
Protein Variants
Commentary
Reference
3.1.3.89
D137A
complete loss of activity
722956
3.1.3.89
D69A
almost complete loss of activity
722956
3.1.3.89
D77A
complete loss of activity
722956
3.1.3.89
E122A
almost complete loss of activity
722956
3.1.3.89
E72A
catalytically inactive. Structures complexed with Co2+ and either TMP or dAMP disclose the unusual binding mode of deoxyribonucleotides in the active site
722956
3.1.3.89
H33A
about 20% of wild-type activity
722956
3.1.3.89
H68A
almost complete loss of activity
722956
3.1.3.89
R18A
almost complete loss of activity
722956
3.1.3.89
V30A
about 80% of wild-type activity
722956
3.1.3.89
V37A
about 85% of wild-type activity
722956
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