EC Number   |
Protein Variants |
Reference |
|---|
   2.7.1.171 | C236A |
site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected |
762465 |
| 2.7.1.171 | C236S |
site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected |
762465 |
| 2.7.1.171 | C32A |
site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected |
762465 |
| 2.7.1.171 | C32A/C236A/C196A |
site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected |
762465 |
| 2.7.1.171 | C32S |
site-directed mutagenesis, similar to the wild-type enzyme, both dimeric and monomeric forms are detected |
762465 |
| 2.7.1.171 | more |
allelic variants of FN3K polymorphisms revealed 13 distinct genotypic variants in a cohort of patients with type 2 diabetes mellitus (T2DM), detection of three polymorphisms associated with the enzymatic activity (rs3859206 and rs2256339 in the promoter region and rs1056534 in exon 6). The FN3K genotype presenting GG at position -385, TT at position -232, and CC at c.900 A, is associated with less severe microangiopathic and macroangiopathic complications as a whole, compared to all other genotypes |
760800 |
| 2.7.1.171 | more |
analysis of the FN3K gene on a Caucasian cohort of diabetic patients, molecular characterization of the FN3K gene by analyzing its promoter and of polymorphisms, c-385A/G (rs3859206) and the c-232A/T (rs2256339), associated with FN3K enzymatic activity in erythrocytes, as well as two variants c-421C/T and c-429delATCGGAG |
738073 |
| 2.7.1.171 | more |
diabetic subjects with the CC variant of SNP rs1056534 (G900C), which is associated with a higher FN3K activity, have lower HbA1c levels compared with other genotypes |
707094 |
| 2.7.1.171 | more |
knockdown of FN3K with two different shRNAs in HepG2 cells and in H3255 cells. The mutant cells have higher levels of NRF2, and both FACS assay and immunoblot show reduction of NRF2 protein upon knockdown of either FN3K or NRF2. FN3K deficiency leads to increased proteasomal and MG132-sensitive degradation of the glycated NRF2 protein |
760823 |
| 2.7.1.171 | more |
the G900C (rs1056534) single nucleotide polymorphism of the FN3K gene is associated with the enzyme activity, with the level of HbA and the onset of the disease, but not with either of the diabetic microvascular complications |
708421 |
