EC Number   |
Protein Variants |
Reference |
|---|
   1.2.1.48 | G412R |
disruption of interaction of side-chains with substrate |
693389 |
| 1.2.1.48 | G185A |
disruption of NAD+ binding/utilisation |
693389 |
| 1.2.1.48 | T184M |
disruption of NAD+ binding/utilisation |
693389 |
| 1.2.1.48 | T184R |
disruption of NAD+ binding/utilisation |
693389 |
| 1.2.1.48 | H411Y |
disruption of the key abstraction of the hydroxyl hydrogen |
693389 |
| 1.2.1.48 | D245N |
NAD+ cosubstrate binding is occuring but catalytic reduction is diminished |
693389 |
| 1.2.1.48 | C241S |
site-directed mutagenesis, inactive active-site mutant |
743336 |
| 1.2.1.48 | E207Q |
site-directed mutagenesis, inactive mutant |
743336 |
| 1.2.1.48 | E331Q |
site-directed mutagenesis, inactive mutant |
743336 |
| 1.2.1.48 | N112A |
site-directed mutagenesis, inactive mutant |
743336 |
