EC Number   |
Protein Variants |
Reference |
|---|
    4.1.1.11 | more |
black1 mutant flies have significantly reduced enzyme activity in adults and at purpuration formation, and no enzyme protein |
665041 |
| 4.1.1.11 | more |
construction of a bp mutant strain 16-100 (bp/bp). In the bp mutant, a SINE-like transposon with a length of 493 bp is detected about 2.2 kb upstream of the transcriptional start site of the BmADC gene. This insertion causes a sharp reduction in BmADC transcript levels in bp mutants, leading to deficiency of beta-alanine and N-beta-alanyl dopamine (NBAD), but accumulation of dopamine. The mutant is specifically melanized only at the pupal stage. Following injection of beta-alanine into bp mutants, the color pattern is reverted to that of the wild-type silkworms. Additionally, melanic pupae resulting from knockdown of BmADC in the wild-type strain are obtained by RNAi of BmADC |
749304 |
| 4.1.1.11 | more |
construction of a panD mutant strain, the panD mutant grows as well as the wild-type in infected mice. Mice infected with wild-type Mycobacterium tuberculosis are treated with pyrazinoic acid (POA), and POA-resistant colonies are confirmed for pyrazinamide (PZA) and POA resistance. Genome sequencing reveals that 82% and 18% of the strains contain missense mutations in panD and clpC1, respectively. Location of amino acid sequence polymorphisms in PanD of POA-resistant Mycobacterium tuberculosis strains isolated from POA-treated mice |
746598 |
| 4.1.1.11 | more |
construction of a TK1814 gene disruption strain, phenotype, overview. The TK1814 strain does not show growth for 24 h, suggesting that the ADC and/or GAD activities of TK1814 are essential for growth in this medium. When exogenous beta-alanine, the product of ADC activity, is added to the medium, the growth defects are almost fully recovered. In contrast, the addition of GABA, the product of GAD activity, does not complement TK1814 disruption at all |
-, 748086 |
| 4.1.1.11 | more |
generation of diverse panD deletion mutant strains, overview |
-, 728266 |
| 4.1.1.11 | more |
generation of knockout mutants DELTApanD (JE13233) and DELTApanM (JE12555) strains |
-, 747435 |
| 4.1.1.11 | more |
inactive Ala-24 and Ala-26 insertion mutants, study of the structure and processing activity |
650998 |
| 4.1.1.11 | S25A |
inactive mutant, study of the structure and processing activity |
650998 |
| 4.1.1.11 | S25T |
inactive mutant, study of the structure and processing activity |
650998 |
| 4.1.1.11 | more |
mutation of nucleotide L127 increases the enzyme's thermostability compared to the wild-type, while mutation of nuclotide V68 does not significantly affect the thermostability |
-, 746859 |
