EC Number   |
Protein Variants |
Reference |
|---|
    3.1.1.45 | S103A |
site-directed mutagenesis, 20% reduced activity compared to the wild-type enzyme |
-, 714312 |
| 3.1.1.45 | S120A |
site-directed mutagenesis, the mutant is 3-5fold less active than the wild-type enzyme |
-, 714312 |
| 3.1.1.45 | S139A |
site-directed mutagenesis, the mutant is 3-5fold less active than the wild-type enzyme |
714312 |
| 3.1.1.45 | S147A |
site-directed mutagenesis, 20% reduced activity compared to the wild-type enzyme |
714312 |
| 3.1.1.45 | S210A |
site-directed mutagenesis, the mutant shows similar activity like the wild-type enzyme |
-, 714312 |
| 3.1.1.45 | Y155C |
site-directed mutagenesis, the enzyme mutant is caused by a single nucleotide polymorphism rs35489000 and shows 50% reduced olmesartan medoxomil-hydrolase activity, slightly higher Km, and lower Vmax compared to the wild-type protein |
729629 |
