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2.6.1.18
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development of beta-phenylalanine ester synthesis method from stable beta-keto ester substrate using engineered omega-transaminase. The omega-transaminase mutants 3FCR_4M and ATA117 11Rd show great potential for further engineering experiments aiming at the synthesis of chiral (S)- and (R)-phenylalanine esters. This alternative approach results in the conversion of 32% and 13% for the (S)- and (R)-enantiomer, respectively. Furthermore, the (S)-phenylalanine ethyl ester is isolated by performing a semi-preparative synthesis
759802
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