EC Number   |
Protein Variants |
Reference |
|---|
    1.2.1.79 | S419A |
mutation of a residue that interacts with the O4 atom or the carboxyl group of succinic semialdehyde thus abolishing enzyme activity |
725523 |
| 1.2.1.79 | S419A |
site-directed mutagenesis, Sp2771 mutant structure analysis and comparison to the wild-type structure |
743181 |
| 1.2.1.79 | S420A |
site-directed mutagenesis, the mutant displays catalytic efficiency (kcat/Km) of only respective 0.4% compared to wild-type enzyme with significantly decreased binding affinity for succinic semialdehyde |
763137 |
| 1.2.1.79 | W135A |
activity of about 1030% of the wild type enzyme, indicating a contribution of these succinic semialdehyde binding residues to the overall enzyme activity |
725523 |
| 1.2.1.79 | Y296A |
site-directed mutagenesis, the mutant shows reduced activity compared tow wild-type enzyme |
763578 |
