EC Number   |
Protein Variants |
Reference |
|---|
    1.1.1.87 | A80del |
site-directed mutagenesis, the mutant shows altered substrate specificity preferring isocitrate to homoisocitrate, it is unable to oxidize 3-isopropylmalate, the specificity is similar to the enzyme from Thermus thermophilus |
660918 |
| 1.1.1.87 | I82N |
the mutant shows decreased catalytic efficiency with homoisocitrate and isocitrate compared to the wild type enzyme and has no activity with 3-isopropylmalate |
-, 760522 |
| 1.1.1.87 | L83R |
the mutant shows decreased catalytic efficiency with homoisocitrate and isocitrate compared to the wild type enzyme and has no activity with 3-isopropylmalate |
-, 760522 |
| 1.1.1.87 | T71V |
the mutant shows decreased catalytic efficiency with homoisocitrate and isocitrate, as well as increased catalytic efficiency with 3-isopropylmalate compared to the wild type enzyme |
-, 760522 |
| 1.1.1.87 | L81P |
the mutant shows decreased catalytic efficiency with homoisocitrate, isocitrate and 3-isopropylmalate compared to the wild type enzyme |
-, 760522 |
| 1.1.1.87 | S80A |
the mutant shows decreased catalytic efficiency with homoisocitrate, isocitrate and 3-isopropylmalate compared to the wild type enzyme |
-, 760522 |
| 1.1.1.87 | more |
trex mutant allele, T to C exchange at nucleotide 251. Midgestation lethal mutant which displays craniofacial, limb, and organ abnormalities due to insufficient retinoic acid signaling |
686950 |
