EC Number   |
Disease |
PubMed ID |
Title of Publication  |
Category |
Confidence Level |
|---|
   3.4.24.77 | Melanoma |
23654233 |
1-Deoxynojirimycin inhibits metastasis of B16F10 melanoma cells by attenuating the activity and expression of matrix metalloproteinases-2 and -9 and altering cell surface glycosylation. |
diagnostic usage
ongoing research
unassigned |
1
3
0 |
| 3.4.24.77 | Osteoarthritis |
19909832 |
10mM glucosamine prevents activation of proADAMTS5 (aggrecanase-2) in transfected cells by interference with post-translational modification of furin. |
ongoing research
unassigned |
4
0 |
| 3.4.24.77 | Infections |
23181168 |
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 3.4.24.77 | Keratitis |
23181168 |
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 3.4.24.77 | Pneumonia |
23181168 |
3-Hydroxy-1-alkyl-2-methylpyridine-4(1H)-thiones: Inhibition of the Pseudomonas aeruginosa Virulence Factor LasB. |
causal interaction
therapeutic application
unassigned |
4
1
0 |
| 3.4.24.77 | Arthritis, Rheumatoid |
10936503 |
4'-Hydroxy aceclofenac suppresses the interleukin-1-induced production of promatrix metalloproteinases and release of sulfated-glycosaminoglycans from rabbit articular chondrocytes. |
therapeutic application
unassigned |
1
0 |
| 3.4.24.77 | Neoplasms |
26352439 |
4-Hydroxyisoleucine improves insulin resistance in HepG2 cells by decreasing TNF-? and regulating the expression of insulin signal transduction proteins. |
diagnostic usage
ongoing research
unassigned |
3
2
0 |
| 3.4.24.77 | Breast Neoplasms |
24633350 |
5-azacytidine induces anoikis, inhibits mammosphere formation and reduces metalloproteinase 9 activity in MCF-7 human breast cancer cells. |
ongoing research
unassigned |
3
0 |
| 3.4.24.77 | Neoplasms |
7682768 |
92-kd gelatinase is actively expressed by eosinophils and stored by neutrophils in squamous cell carcinoma. |
causal interaction
diagnostic usage
ongoing research
unassigned |
3
3
3
0 |
| 3.4.24.77 | Hypertension |
26254330 |
?-Lipoic acid reduces neurogenic hypertension by blunting oxidative stress-mediated increase in ADAM17. |
causal interaction
ongoing research
therapeutic application
unassigned |
4
2
1
0 |
