EC Number   |
Disease |
PubMed ID |
Title of Publication |
Category  |
Confidence Level |
|---|
    1.3.98.1 | Autoimmune Diseases |
27721149 |
Dihydroorotate dehydrogenase: A drug target for the development of antimalarials. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 1.3.98.1 | Autoimmune Diseases |
32353424 |
Natural product piperine alleviates experimental allergic encephalomyelitis in mice by targeting dihydroorotate dehydrogenase. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 1.3.98.1 | Breast Neoplasms |
28196676 |
Dihydroorotate dehydrogenase (DHODH) inhibitors affect ATP depletion, endogenous ROS and mediate S-phase arrest in breast cancer cells. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
3
4
0 |
| 1.3.98.1 | Chagas Disease |
24084894 |
Computational study of the mechanism of half-reactions in class 1A dihydroorotate dehydrogenase from Trypanosoma cruzi. |
causal interaction
therapeutic application
unassigned |
2
3
0 |
| 1.3.98.1 | Lymphoma |
28928900 |
Dihydroorotate dehydrogenase Inhibitors Target c-Myc and Arrest Melanoma, Myeloma and Lymphoma cells at S-phase. |
causal interaction
therapeutic application
unassigned |
3
4
0 |
| 1.3.98.1 | Melanoma |
21430780 |
DHODH modulates transcriptional elongation in the neural crest and melanoma. |
causal interaction
diagnostic usage
therapeutic application
unassigned |
1
3
3
0 |
| 1.3.98.1 | Neoplasms |
33120310 |
Quantitation of uridine and L-dihydroorotic acid in human plasma by LC-MS/MS using a surrogate matrix approach. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 1.3.98.1 | Neoplasms |
33971967 |
DHODH and cancer: promising prospects to be explored. |
causal interaction
ongoing research
therapeutic application
unassigned |
3
2
2
0 |
| 1.3.98.1 | Neoplasms |
34113829 |
DHODH inhibition modulates glucose metabolism and circulating GDF15, and improves metabolic balance. |
causal interaction
therapeutic application
unassigned |
4
4
0 |
| 1.3.98.1 | Autoimmune Diseases |
32696396 |
A Small-Scale Medication of Leflunomide as a Treatment of COVID-19 in an Open-Label Blank-Controlled Clinical Trial. |
causal interaction
diagnostic usage
ongoing research
therapeutic application |
3
1
3
4 |
