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EC Number	pH Minimum	pH Maximum	Commentary	Reference
2.7.10.1	4.3	6.3	under acidic conditions, the N terminus of the transmembrane helix is stabilized by an N-capping box formed by the uncharged carboxyl group of Glu547, whereas its deprotonation results in a rearrangement of hydrogen bonds, fractional unfolding of the helix, and a realignment of the helix-helix packing with appearance of additional minor dimer conformation utilizing seemingly the C-terminal GG4-like dimerization motif A560X3G564	693156

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Release 2023.1 (January 2023)