EC Number   |
|---|
   3.5.4.36 | - |
| 3.5.4.36 | characterization of the APOBEC-1 gene and an unusual aberrant splicing pattern of the pre-mRNA |
| 3.5.4.36 | expressed in Escherichia coli, as a glutathione S-transferase fusion protein. Overexpression of wild-type apobec-1 in McA 7777 cells results in a 5-6-fold increase in editing of endogenous apoB |
| 3.5.4.36 | expression in COS-7 cells |
| 3.5.4.36 | expression in Escherichia coli |
| 3.5.4.36 | expression in Escherichia coli or in Sf9 cells |
| 3.5.4.36 | expression in Escherichia coli, the opossum APOBEC-1 gene has the same intron/exon organisation in the coding sequence as the eutherian gene |
| 3.5.4.36 | expression of the catalytic subunit of the editing enzyme, p27, in McArdle 7777 cells and in in COS cells. Transfected COS and CHO cells express p27 but lack additional proteins that are required for editing |
| 3.5.4.36 | high level expression of APOBEC1 in Sf9 cells as an N-terminal GST fusion protein. Substantial RNA editing activity of APOBEC1 alone may be responsible for the hyperediting observed upon overexpression of APOBEC1 in transgenic mice. These animals develop hepatocellular carcinomas |
| 3.5.4.36 | when the catalytic subunit of the editing enzyme, p27, is expressed in Xenopus oocytes, it requires other proteins to edit apoB mRNA in vitro |
