EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
6.3.1.8 | gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP |
synthesis of trypanothione, which is involved in maintaining intracellular thiol redox and in defense against oxidants |
Crithidia fasciculata |
? |
- |
? |
6.3.1.8 | gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP |
key enzyme that participates in the first of two similar steps of trypanothione biosynthesis |
Escherichia coli |
? |
- |
? |
6.3.1.8 | gamma-L-Glutamyl-L-cysteinyl-glycine + spermidine + ATP |
the enzyme is involved in the biosynthesis of the trypanosomatid-specific dithiol trypanothione |
Crithidia fasciculata |
? |
- |
? |
6.3.1.8 | more |
important reaction in defense against chemical and oxidant stress, thiol redox homeostasis, ribonucleotide metabolism, and drug resistance in parasitic kinetoplastids |
Trypanosoma brucei |
? |
- |
? |
6.3.1.8 | more |
the enzyme is important for several functions, e.g. for detoxification of H2O2 and organic hyperoxids, and ribonucleotide reduction |
Trypanosoma brucei |
? |
- |
? |
6.3.1.8 | more |
the trypanothione synthase also converts glutathionylspermidine further to trypanothione catalyzing the reaction of EC 6.3.1.9 |
Crithidia fasciculata |
? |
- |
? |
6.3.1.8 | more |
model of ter-reactant mechanism of GspS catalysis and postulated overview |
Crithidia fasciculata |
? |
- |
? |
6.3.1.8 | more |
Escherichia coli proteins YgiC and YjfC, encoded by genes ygiC and yjfC, cannot synthesize G-Sp, GSH, or GSH intermediates, they are no glutathionylspermidine synthetase/amidases, but show ATP-hydrolysis activity |
Escherichia coli |
? |
- |
? |
6.3.1.8 | glutathionylspermidine + H2O |
amidase activity |
Crithidia fasciculata |
glutathione + spermidine |
- |
? |
6.3.1.8 | glutathione + spermidine + ATP |
- |
Crithidia fasciculata |
glutathionylspermidine + ADP + phosphate |
- |
? |