EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   4.2.3.190 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate |
- |
Salvia rosmarinus |
manoyl oxide + diphosphate |
- |
? |
| 4.2.3.190 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate |
- |
Marrubium vulgare |
manoyl oxide + diphosphate |
- |
? |
| 4.2.3.190 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate |
- |
Plectranthus barbatus |
manoyl oxide + diphosphate |
- |
? |
| 4.2.3.190 | (13E)-8alpha-hydroxylabd-13-en-15-yl diphosphate |
- |
Grindelia hirsutula |
manoyl oxide + diphosphate |
- |
? |
| 4.2.3.190 | more |
ELS is active in vitro and in vivo with three different prenyl diphosphate substrates forming the marrubiin precursor 9,13-epoxy-labd-14-ene, i.e. reaction of EC 4.2.3.189, manoyl oxide and miltiradiene, reaction of EC 4.2.3.131 |
Marrubium vulgare |
? |
- |
? |
| 4.2.3.190 | more |
bifunctional enzyme, catalyzing the reaction of (+)-copalyl diphosphate to miltiradiene, EC 4.2.3.131 and, in combination with Nicotinana tabacum CPS2 the synthesis of manoyl oxide |
Salvia rosmarinus |
? |
- |
? |
| 4.2.3.190 | more |
reaction proceeds via cleavage of the diphosphate group of LPP and subsequent heterocyclic ring closure including the hydroxyl group at C-8 |
Grindelia hirsutula |
? |
- |
? |
