EC Number   |
Substrates |
Organism |
Products |
Reversibility |
|---|
   3.4.22.B70 | (SUMO-1)-androgen receptor conjugate + H2O |
- |
Homo sapiens |
SUMO-1 + androgen receptor conjugate |
- |
? |
| 3.4.22.B70 | (SUMO-1)-androgen receptor conjugate + H2O |
SENP1 markedly contributes to the androgen-stimulated proliferation of prostate cancer cells |
Homo sapiens |
SUMO-1 + androgen receptor conjugate |
- |
? |
| 3.4.22.B70 | (SUMO-1)-histone deacetylase 1 conjugate + H2O |
- |
Homo sapiens |
SUMO-1 + histone deacetylase 1 |
- |
? |
| 3.4.22.B70 | (SUMO-1)-histone deacetylase 1 conjugate + H2O |
SENP1 regulates that androgen receptor-dependent transcription through desumoylation of histone deacetylase 1 (HDAC1) |
Homo sapiens |
SUMO-1 + histone deacetylase 1 |
- |
? |
| 3.4.22.B70 | (SUMO-1)-homeodomain-interacting protein kinase 2 conjugate + H2O |
- |
Homo sapiens |
SUMO-1 + homeodomain-interacting protein kinase 2 conjugate |
- |
? |
| 3.4.22.B70 | (SUMO-1)-homeodomain-interacting protein kinase 2 conjugate + H2O |
desumoylation of homeodomain-interacting protein kinase 2 (HIPK2) may be regulated by the cytoplasmic-nuclear shuttling of SENP1. Desumoylation induces dissociation of homeodomain-interacting protein kinase 2 conjugate from nuclear bodies |
Homo sapiens |
SUMO-1 + homeodomain-interacting protein kinase 2 conjugate |
- |
? |
| 3.4.22.B70 | (SUMO-1)-K2P1 potassium channel + H2O |
silent K2P1 channels in excised plasma membrane patches are activated by SENP1 |
Homo sapiens |
SUMO-1 + K2P1 potassium channel |
- |
? |
| 3.4.22.B70 | (SUMO-1)-K2P1 subunit of potassium channel + H2O |
SUMO1 is conjugated to the epsilon-amino group of Lys274 of the K2P1 potassium channel. When mutated to Gln, Arg, Glu, Asp, Cys, or Ala, the channels are constitutively active and insensitive to SUMO1 and SENP1. Wild-type channels in plasma membrane have two K2P1 subunits and assemble with two SUMO1 monomers. Although channels engineered with one Lys274 site carry just one SUMO1 they are activated and silenced by SENP1 and SUMO1 like wild-type channels |
Homo sapiens |
SUMO-1 + K2P1 subunit of potassium channel |
- |
? |
| 3.4.22.B70 | (SUMO-1)-Ran GTPase-activating protein 1 conjugate + H2O |
rates at which SUMO-1, SUMO-2 and SUMO-3 are deconjugated from RanGAP1 are indistinguishable |
Homo sapiens |
SUMO-1 + Ran GTPase-activating protein 1 |
- |
? |
| 3.4.22.B70 | (SUMO-1)-RanGAP1 conjugate + H2O |
SENP1 binding is accompanied by a conformational change in the substrate |
Homo sapiens |
SUMO-1 + RanGAP1 |
- |
? |
