EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.3.1.230 | 3-oxodecanoate + 2-aminobenzoyl-CoA |
- |
Pseudomonas aeruginosa |
CoA + 2-heptyl-4(1H)-quinolone + CO2 + H2O |
- |
? |
2.3.1.230 | 3-oxodecanoate + 2-aminobenzoyl-CoA |
- |
Pseudomonas aeruginosa |
CoA + 2-heptyl-4-hydroxyquinoline + CO2 + H2O |
- |
? |
2.3.1.230 | 3-oxodecanoyl-CoA + 2-aminobenzoyl-CoA |
high concentrations and a longer incubation time is required in comparison to the free 3-oxodecanoic acid |
Pseudomonas aeruginosa |
2 CoA + 2-heptyl-3-hydroxy-4(1H)-quinolone + CO2 |
- |
? |
2.3.1.230 | 3-oxodecanoyl-N-acetylcysteamine + 2-aminobenzoyl-CoA |
high concentrations and a longer incubation time is required in comparison to the free 3-oxodecanoic acid |
Pseudomonas aeruginosa |
N-acetylcysteamine + 2-heptyl-3-hydroxy-4(1H)-quinolone + CO2 |
- |
? |
2.3.1.230 | 3-oxohexanoate + 2-aminobenzoyl-CoA |
- |
Pseudomonas aeruginosa |
CoA + 2-propyl-4(1H)-quinolone + CO2 + H2O |
- |
? |
2.3.1.230 | 3-oxopentanoate + 2-aminobenzoyl-CoA |
- |
Pseudomonas aeruginosa |
CoA + 2-ethyl-4(1H)-quinolone + CO2 + H2O |
- |
? |
2.3.1.230 | malonyl-CoA + 2-aminobenzoyl-CoA |
2-aminobenzoyl-CoA i.e. anthraniloyl-CoA |
Pseudomonas aeruginosa |
2 CoA + 4-hydroxy-2(1H)-quinolone + CO2 |
i.e. 2,4-dihydroxyquinoline |
? |
2.3.1.230 | malonyl-CoA + 2-aminobenzoyl-CoA |
2-aminobenzoyl-CoA i.e. anthraniloyl-CoA. PqsD is a key enzyme in the biosynthesis of the signal molecules 2-heptyl-4-hydroxyquinoline and 4-hydroxy-2(1H)-quinolone, that are involved in regulation of virulence factor production and biofilm formation |
Pseudomonas aeruginosa |
2 CoA + 4-hydroxy-2(1H)-quinolone + CO2 |
i.e. 2,4-dihydroxyquinoline |
? |
2.3.1.230 | malonyl-CoA + 2-aminobenzoyl-CoA |
2-aminobenzoyl-CoA i.e. anthraniloyl-CoA. The enzyme is involved in the biosynthesis of the Pseudomonas Quinolone Signal |
Pseudomonas aeruginosa |
2 CoA + 4-hydroxy-2(1H)-quinolone + CO2 |
i.e. 2,4-dihydroxyquinoline |
? |
2.3.1.230 | malonyl-CoA + 2-aminobenzoyl-CoA |
the enzyme is involved in the biosynthesis of 2,4-dihydroxyquinoline. Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that is a highly interactive organism secreting a variety of chemical signals. One intercellular signaling system unique to Pseudomonas and Burkholderia species is the production of hydrophobic quinolines. These quinoline derivatives are 4-hydroxy-2-heptylquinoline, 3,4-dihydroxy-2-heptylquinoline, and 2,4-dihydroxyquinoline |
Pseudomonas aeruginosa |
2 CoA + 4-hydroxy-2(1H)-quinolone + CO2 |
i.e. 2,4-dihydroxyquinoline |
? |