EC Number   |
Substrates |
Organism |
Products |
Reversibility  |
|---|
   2.1.1.42 | more |
enzyme shows methylation activity for the 3-, 5-, 6-, and 7-hydroxyl groups of flavones. The highest activity is observed for 3-hydroxyflavone (flavonol), followed by 7-hydroxyflavone with a relative activity of 15.6% of that of 3-hydroxyflavone and 5-hydroxyflavone with that of 13.5%. Very weak activity is observed for 6-hydroxyflavone and no activity for 3'- or 4'-hydroxyflavone and 7-methoxy-8-hydroxyflavone. FOMT5 does not exhibit a sequential methylation order for 3-, 5-, and 7-hydroxyl groups of quercetin. No detection of polymethylated products from naringenin, (-)-epicatechin, and equol, and cyanidin is not a substrate |
Citrus depressa |
? |
- |
- |
| 2.1.1.42 | 4 S-adenosyl-L-methionine + quercetin |
- |
Citrus depressa |
4 S-adenosyl-L-homocysteine + 3,3',5,7-tetra-O-methyl-quercetin |
- |
? |
| 2.1.1.42 | luteolin + S-adenosyl-L-methionine |
high 3'-O-methyltransferase activity |
Glycine max |
3'-O-methyl luteolin + S-adenosyl-L-homocysteine |
i.e. chrysoeriol |
? |
| 2.1.1.42 | luteolin + S-adenosyl-L-methionine |
OMT-15 shows 92% activity and OMT-17 shows 84% activity compared to myricetin |
Oryza sativa |
3'-O-methylluteolin + S-adenosyl-L-homocysteine |
- |
? |
| 2.1.1.42 | more |
- |
Petroselinum crispum |
? |
- |
? |
| 2.1.1.42 | more |
isomeric substances isoferulic acid and diosmetin, chrysoeriol, apigenin p-cumaric acid and ferulic acid are not substrates |
Petroselinum crispum |
? |
- |
? |
| 2.1.1.42 | more |
only ortho-dihydric phenols can function as substrates and only the meta-hydroxyl group is methylated, no reaction takes place if one of the two phenolic hydroxyls is methylated or if only one hydroxyl group is present |
Petroselinum crispum |
? |
- |
? |
| 2.1.1.42 | more |
rutin is no substrate |
Nicotiana tabacum |
? |
- |
? |
| 2.1.1.42 | more |
methylation proceedes only in the meta-position, enzyme is unable to catalyze the methylation of p-coumaric acid, m-coumaric acid, ferulic acid, isoferulic acid, sinapic acid, apigenin and naringenin |
Glycine max |
? |
- |
? |
| 2.1.1.42 | more |
isoflavones biochanin A and daidzein do not serve as substrates |
Glycine max |
? |
- |
? |
