EC Number |
Substrates |
Organism |
Products |
Reversibility |
---|
2.1.1.320 | 2 S-adenosyl-L-methionine + [D2 dopamine receptor]-L-arginine |
recombinant fragment of the third intracellular loop of D2, corresponding to amino acid residues 211 to 241 fused to glutathione S-transferase. Residues Arg217 and Arg219 are key methylation sites within this region |
Homo sapiens |
2 S-adenosyl-L-homocysteine + [D2 dopamine receptor]-Nomega,Nomega'-dimethyl-L-arginine |
- |
? |
2.1.1.320 | 2 S-adenosyl-L-methionine + [DOP-3 receptor]-L-arginine |
recombinant fragment of the third intracellular loop of Caenorhabditis elegans DOP-3, amino acid residues 202 to 232 fused to GST. Residues Arg208 and Arg210 are key methylation sites within this region |
Homo sapiens |
2 S-adenosyl-L-homocysteine + [DOP-3 receptor]-Nomega,Nomega'-dimethyl-L-arginine |
- |
? |
2.1.1.320 | 2 S-adenosyl-L-methionine + [germ cell-specific protein Vasa]-L-arginine |
- |
Danio rerio |
2 S-adenosyl-L-homocysteine + [germ cell-specific protein Vasa]-Nomega,Nomega'-dimethyl-L-arginine |
- |
? |
2.1.1.320 | 2 S-adenosyl-L-methionine + [germ cell-specific protein Vasa]-L-arginine |
seven arginine residues in Vasa, including R101, R105, R177, R179, R183, R197 and R201, and two arginine residues in Zili, including R68 and R221, are dimethylated in vivo. Vasa mutant with seven arginines to lysines (Vasa-7M: R101K, R105K, R177K, R179K, R183K, R197K and R201K) can not be dimethylated by Prmt5 |
Danio rerio |
2 S-adenosyl-L-homocysteine + [germ cell-specific protein Vasa]-Nomega,Nomega'-dimethyl-L-arginine |
- |
? |
2.1.1.320 | 2 S-adenosyl-L-methionine + [germ cell-specific protein Zili]-L-arginine |
- |
Danio rerio |
2 S-adenosyl-L-homocysteine + [germ cell-specific protein Zili]-Nomega,Nomega'-dimethyl-L-arginine |
- |
? |
2.1.1.320 | 2 S-adenosyl-L-methionine + [germ cell-specific protein Zili]-L-arginine |
two arginine residues in Zili, including R68 and R221, are dimethylated in vivo. Zili mutant with two arginines to lysines [Zili (1-133aa)-R68/221K] can not be dimethylated by Prmt5 |
Danio rerio |
2 S-adenosyl-L-homocysteine + [germ cell-specific protein Zili]-Nomega,Nomega'-dimethyl-L-arginine |
- |
? |
2.1.1.320 | 2 S-adenosyl-L-methionine + [golgin GM130]-L-arginine |
- |
Homo sapiens |
2 S-adenosyl-L-homocysteine + [golgin GM130]-Nomega,Nomega'-dimethyl-L-arginine |
overall reaction |
? |
2.1.1.320 | 2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine |
- |
Homo sapiens |
2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine |
- |
? |
2.1.1.320 | 2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine |
- |
Mus musculus |
2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine |
- |
? |
2.1.1.320 | 2 S-adenosyl-L-methionine + [histone H3R2]-L-arginine |
the enzyme (PRMT5) catalyse the formation of either activating H3R2me2s or repressive H3R8me2s and H4R3me2s marks as a part of epigenetic histone code |
Homo sapiens |
2 S-adenosyl-L-homocysteine + [histone H3R2]-Nomega,Nomega'-dimethyl-L-arginine |
- |
? |